2009
DOI: 10.1093/nar/gkp219
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Non-specific interactions are sufficient to explain the position of heterochromatic chromocenters and nucleoli in interphase nuclei

Abstract: The organization of the eukaryote nucleus into functional compartments arises by self-organization both through specific protein–protein and protein–DNA interactions and non-specific interactions that lead to entropic effects, such as e.g. depletion attraction. While many specific interactions have so far been demonstrated, the contributions of non-specific interactions are still unclear. We used coarse-grained molecular dynamics simulations of previously published models for Arabidopsis thaliana chromatin org… Show more

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Cited by 78 publications
(110 citation statements)
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“…Simulations show that this segregation can be understood by the entropic repulsion which occurs between polymers containing loops [44,54]. The preferential positioning of generich and transcriptionally active chromosomes in central regions of the nucleus while inactive chromosomes are more peripheral [55] (Figure 1C) can be explained by entropic effects resulting from a higher frequency of loops in more compact inactive chromatin [52].…”
Section: Chromosome Territoriesmentioning
confidence: 94%
“…Simulations show that this segregation can be understood by the entropic repulsion which occurs between polymers containing loops [44,54]. The preferential positioning of generich and transcriptionally active chromosomes in central regions of the nucleus while inactive chromosomes are more peripheral [55] (Figure 1C) can be explained by entropic effects resulting from a higher frequency of loops in more compact inactive chromatin [52].…”
Section: Chromosome Territoriesmentioning
confidence: 94%
“…These experiments confirmed the position of chromocentres next to the nuclear periphery and the nucleolus. Furthermore, modelling also predicted that chromocentres would tend to be located at the nuclear periphery (de Nooijer et al, 2009).…”
Section: Different Cell Types Show Quantitative Variations In Nuclearmentioning
confidence: 99%
“…1B). Chromocenters of most Arabidopsis chromosomes do not seem to show preferential positioning relative to each other (Pecinka et al, 2004;Berr and Schubert, 2007;de Nooijer et al, 2009). Exceptions to this rule are chromosomes carrying nucleolar organizing regions (NORs), which contain tandemly arranged copies of rRNA genes (Pecinka et al, 2004).…”
Section: Interphase Chromosome Organization In Arabidopsismentioning
confidence: 99%