Non-specific modulation of the immune response with liposomal meningococcal lipopolysaccharide: role of different cells and cytokines

Petrov, A B; Kolenko, Vladimir; Koshkina, Nadezhda V.; Zakirov, M M; Bugaev, Lev V.; Семенова, И. Б.; Wiertz, Emmanuel J. H. J.; Poolman, Jan

doi:10.1016/0264-410x(94)90174-0

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…In preliminary studies we showed that the incorporation of LPS (1%) into SL can increase their binding to FSDC, suggesting that at least some of the liposome-associated LPS can interact with DC surface receptors, consistent with previous observations (37). In addition, evidence suggests that liposome-associated IFN-␥ is biologically active and that IFN-␥ can be encapsulated within liposomes and as well can bind to the outer surface of liposomes (38,39).…”

Section: Resultssupporting

confidence: 62%

Targeting Dendritic Cells with Antigen-Containing Liposomes

Broekhoven¹,

et al. 2004

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Section: Resultssupporting

confidence: 62%

Targeting Dendritic Cells with Antigen-Containing Liposomes

Broekhoven¹,

et al. 2004

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“…LPS is an amphiphilic molecule that comprises a strainspecific side-chain known as the O-antigen, a core polysaccharide, and conserved lipid tails in the lipid A region. LPS has been incorporated into liposomes [74][75][76][77] and gelatin particles [78] for vaccine delivery, which results in high titers of antigen-specific antibodies. Our recent work with LPS immobilized on the surface of PLGA particles loaded with antigen has demonstrated that LPS-modified particles are preferentially internalized by DCs compared to uncoated nanoparticles; furthermore, the system, when administered to mice, elicits potent humoral and cellular immunity against a model antigen, ovalbumin, and the antigen derived from the West Nile envelope protein [79].…”

Section: Recognition Of Surface Carbohydrates: Tlr4 Like Surface Protmentioning

confidence: 99%

Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

Demento

Siefert

Bandyopadhyay

et al. 2011

Trends in Biotechnology

158

120

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Vaccine development has progressed significantly and has moved from whole microorganisms to subunit vaccines that contain only their antigenic proteins. Subunit vaccines are often less immunogenic than whole pathogens; therefore, adjuvants must amplify the immune response, ideally establishing both innate and adaptive immunity. Incorporation of antigens into biomaterials, such as liposomes and polymers, can achieve a desired vaccine response. The physical properties of these platforms can be easily manipulated, thus allowing for controlled delivery of immunostimulatory factors and presentation of pathogen-associated molecular patterns (PAMPs) that are targeted to specific immune cells. Targeting antigen to immune cells via PAMP-modified biomaterials is a new strategy to control the subsequent development of immunity and, in turn, effective vaccination. Here, we review the recent advances in both immunology and biomaterial engineering that have brought particulate-based vaccines to reality.

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“…Mice injected with lipopolysaccharide (LPS) exhibit a peak polyclonal B cell proliferation at 2 days post injection 14Fig.…”

Section: Resultsmentioning

confidence: 99%

The Mesenchymal Stroma Negatively Regulates B Cell Lymphopoiesis through the Expression of Activin A

Shoham

Parameswaran

Shav‐Tal

et al. 2003

Annals of the New York Academy of Sciences

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The negative control of B cell generation is only partially resolved. We assessed the role of activin A in regulation of B lymphopoiesis in view of its specific inhibitory effects on tumor B lineage cells. Activin A is constitutively expressed in mouse hemopoietic organs and in cultured mesenchymal cell lines. We observed an inverse relationship between activin A titer and B lineage cell production. In the spleen, the red pulp exhibited a relatively higher abundance of the protein as compared with the lymphoid follicles, wherein B cell accumulation occurs. Furthermore, a specific shut off in activin A expression was observed in bone marrow and spleen following in vivo induction of B lymphocyte polyclonal activation. We further substantiated these in vivo observations by in vitro studies of primary bone marrow cultures, in which the expression of functional activin A was found to be diminished prior to the onset of B lymphopoiesis. The reduction in functional activin A is shown to concomitantly occur with spontaneous induction of the expression of activin A specific inhibitors. We therefore propose that the mesenchymal organ stroma expresses activin A that negatively controls B cell lymphopoiesis.

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Non-specific modulation of the immune response with liposomal meningococcal lipopolysaccharide: role of different cells and cytokines

Cited by 7 publications

References 27 publications

Targeting Dendritic Cells with Antigen-Containing Liposomes

Targeting Dendritic Cells with Antigen-Containing Liposomes

Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

The Mesenchymal Stroma Negatively Regulates B Cell Lymphopoiesis through the Expression of Activin A

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