Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method

Tanprasert, Sorathan; Kampeewichean, Chanida; Shiratori, Shuichi; Piemjaiswang, Ratchanon; Chalermsinsuwan, Benjapon

doi:10.1016/j.ijpharm.2023.122979

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…Several attempts have been made to address anisotropic particle flow in RBC‐free set‐up, [ 184 ] in the presence of RBCs, [ 185,186 ] its adhesiveness, [ 91 ] drug release, [ 187 ] and particle deposition in the human airway. [ 188 ] The versatility of anisotropic DDSs raises a temptation to apply modern methods of quantifications on how the design of the DDS should be engineered to facilitate the flow and uptake as well as guiding with physical external impact exploiting particle anisotropy. While uncertainty quantifications are applied for drug design, [ 189 ] in the area of anisotropic DDS these methods are yet to correlate computational approaches with uncurtains occurring in real life, that is, in vivo behavior, are not yet there.…”

Section: Summary and Prospectmentioning

confidence: 99%

Features of Anisotropic Drug Delivery Systems

Kudryavtseva,

Sukhorukov

2024

Advanced Materials

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Natural materials are anisotropic. Delivery systems occurring in nature, such as viruses, blood cells, pollen, and many others, do have anisotropy, while delivery systems made artificially are mostly isotropic. There is apparent complexity in engineering anisotropic particles or capsules with micron and submicron sizes. Nevertheless, some promising examples of how to fabricate particles with anisotropic shapes or having anisotropic chemical and/or physical properties have been developed. Anisotropy of particles, once they face biological systems, influences their behaviour. Internalisation by the cells, flow in the bloodstream, biodistribution over organs and tissues, directed release, and toxicity of particles regardless of the same chemistry are all reported to be factors of anisotropy of delivery systems. Here, we review the current methods to introduce anisotropy to particles or capsules, including loading with various therapeutic cargo, variable physical properties primarily by anisotropic magnetic properties, controlling directional motion, and making Janus particles. The advantages of combining different anisotropy in one entity for delivery and common problems and limitations for fabrication are under discussion.This article is protected by copyright. All rights reserved

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Section: Summary and Prospectmentioning

confidence: 99%

Features of Anisotropic Drug Delivery Systems

Kudryavtseva,

Sukhorukov

2024

Advanced Materials

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“…In this regard, computational fluid dynamics (CFD) stands out as a key numerical tool, offering a versatile approach to analyze and simulate complex airflow patterns within the human respiratory system [14][15][16][17]. In the last decade, different authors have exploited numerical tools to model the human airways [18][19][20][21][22][23]. Several studies explored the capabilities of CFD models as a tool to investigate lung injuries [24][25][26] as well as to optimize drug deposition in human airways [22,23,[27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

A Parametric 3D Model of Human Airways for Particle Drug Delivery and Deposition

Geronzi,

Fanni,

De Jong

et al. 2024

Fluids

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The treatment for asthma and chronic obstructive pulmonary disease relies on forced inhalation of drug particles. Their distribution is essential for maximizing the outcomes. Patient-specific computational fluid dynamics (CFD) simulations can be used to optimize these therapies. In this regard, this study focuses on creating a parametric model of the human respiratory tract from which synthetic anatomies for particle deposition analysis through CFD simulation could be derived. A baseline geometry up to the fourth generation of bronchioles was extracted from a CT dataset. Radial basis function (RBF) mesh morphing acting on a dedicated tree structure was used to modify this baseline mesh, extracting 1000 synthetic anatomies. A total of 26 geometrical parameters affecting branch lengths, angles, and diameters were controlled. Morphed models underwent CFD simulations to analyze airflow and particle dynamics. Mesh morphing was crucial in generating high-quality computational grids, with 96% of the synthetic database being immediately suitable for accurate CFD simulations. Variations in wall shear stress, particle accretion rate, and turbulent kinetic energy across different anatomies highlighted the impact of the anatomical shape on drug delivery and deposition. The study successfully demonstrates the potential of tree-structure-based RBF mesh morphing in generating parametric airways for drug delivery studies.

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The airflow and the regional particle behavior in a human airway under the circulatory breathing conditions: A numerical study

Ciloglu

2024

Journal of Drug Delivery Science and Technology

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Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method

Cited by 7 publications

References 47 publications

Features of Anisotropic Drug Delivery Systems

Features of Anisotropic Drug Delivery Systems

A Parametric 3D Model of Human Airways for Particle Drug Delivery and Deposition

The airflow and the regional particle behavior in a human airway under the circulatory breathing conditions: A numerical study

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