Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings

Doğan, Serap; Vural, Alperen; Kahriman, Güven; İmamoğlu, Hakan; Abdülrezzak, Ümmühan; Öztürk, Mustafa

doi:10.1016/j.bjorl.2019.02.003

Cited by 14 publications

(13 citation statements)

References 29 publications

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“…According to the recent literature, the majority of publications are case reports or small case series [3,4,[11][12][13][14][15][16][17], including both malignant and benign neoplasms [12] and even non-neoplastic lesions [3]. Nevertheless, cohort studies and cross-sectional population analysis [9,18] considered only OS as survival end point.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, our study is the first to compare several oncological outcomes (OS, DSS, and DFS) and a functional one, such as the TLFS, between SCC and non-SCC. Unlike past studies [3,9,10,12,13], we did not include laryngeal lymphoma or metastatic location to the Fig. 3 A Forest plot of multivariable disease-specific survival analysis (DSS); survival curves derived from the multivariable DSS model showing the marginal effect of the stage (B) and of the histological type (C), adjusted for the effects of other covariates.…”

Section: Discussionmentioning

confidence: 99%

“…The entire group of these tumors is considered as rare non-SCC tumors [ 2 ]. The usual submucosal growth pattern and supraglottic or subglottic location frequently cause a delay in diagnosis, which might happen at an intermediate-advanced local stage [ 3 ]. Due to the paucity of cases, outcomes associated with non-SCC laryngeal cancers are not well characterized.…”

Section: Introductionmentioning

confidence: 99%

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Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

Iandelli

Missale

Laborai

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Non-squamous cell carcinoma (non-SCC) accounts for about 5% of laryngeal malignancies. Survival data are limited, and consensus on management principles is lacking. The present study reviews our experience in the surgical treatment of non-metastatic non-SCC of the larynx and compares oncological and functional outcomes in a cohort of patients affected by traditional SCC. Methods We collected data on 592 patients affected by laryngeal neoplasms. Univariate and multivariable survival analyses were performed using Cox proportional-hazards models; survival estimates were reported by hazard ratios (HR) with 95% confidence intervals (CI), and survival curves were established with the Kaplan–Meier method. Results We identified 326 patients affected by untreated SCC, while 21 had non-SCC histotypes. The non-SCC cohort was composed of 5 soft tissue sarcomas, 8 chondrosarcomas, 2 adenoid cystic carcinomas, 2 neuroendocrine carcinomas, 2 solitary fibrous tumors, 1 Kaposi’s sarcoma, and 1 malignant peripheral nerve sheath tumor. Overall survival and disease-specific survival were not significantly different according to histology (p = 0.6 and p = 0.349, respectively). The non-SCC group showed an increased risk of recurrence (HR 5.87; CI95 2.15–16.06; p < 0.001). Nonetheless, no significant difference (p = 0.31) was found at multivariable analysis between the two groups in total laryngectomy-free survival with an organ preservation rate over 5 years of 81% for the non-SCC histologies. Conclusion Non-SCC is a broad spectrum pathology, but generalized laryngeal surgical management principles are still feasible and it is possible to identify patients amenable to conservative surgical treatment without affecting survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

Iandelli

Missale

Laborai

et al. 2021

Eur Arch Otorhinolaryngol

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“…However, there are a limited number of reported cases in the literature of non-squamous carcinomas of the larynx. Primary laryngeal non-Hodgkin lymphoma is a rare condition and accounts for <1% of laryngeal tumors [6]. Besides malignancy, other granulomatous processes that can present with laryngeal involvement and that should be included in the differential include granulomatosis with polyangiitis, sarcoidosis, syphilis, and fungal infections such as histoplasmosis, blastomycosis, and coccidioidomycosis [7].…”

Section: Discussionmentioning

confidence: 99%

A Case of Laryngeal Tuberculosis Mimicking Lymphoma

Garza¹,

Flores²,

Grosu³

2021

Cureus

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The incidence of laryngeal tuberculosis has steadily increased due to rising prevalence of HIV infection, immunosuppressive diseases and treatments, and the emergence of multidrug-resistant organisms and atypical mycobacteria. We report on a woman with a unique presentation of laryngeal tuberculosis mimicking lymphoma to remind clinicians that the diagnosis of laryngeal tuberculosis merits awareness and that delay in diagnosis poses a serious threat to the patient due to delayed treatment and further complications.

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“…Besides lymphoma and squamous cell carcinoma, it is also necessary to differentiate them from other laryngeal masses located in the mucosal or submucosal with homogeneous enhancement [12]. Neuroendocrine tumor-atipical carcinoid, paraganglioma, schwannoma, adenoid cystic carcinoma and other minor salivary tumors, sarcoma, tuberculoma, tumorlike lesions (Brown tumor and in ammatory myo broblastic tumor), and in ammatory lesions should all be considered [23].…”

Section: Ct and Mr Featuresmentioning

confidence: 99%

Imaging Characteristics of Primary Non-Hodgkin's Lymphoma of The Larynx

Chen

Pingding

Ding

et al. 2021

Preprint

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Purpose This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI)characteristics of primary Non-Hodgkin's Lymphoma (NHL) of the larynx. Materials and methods The radiographic examinations of five patients (2 men, 3 women; median age, 68years) with histopathologically proven NHL of the larynx were retrospectively reviewed. CT and MRI images were analyzed qualitatively (Tumor distribution, Local tumor invasion, Tumor appearance, Cervical lymphadenopathy of NHL). Results CT and MRI images showed no obvious signs of vascular and laryngeal cartilage invasion. Three cases (1 MALT, 2 diffuse large B-cell lymphomas (DLBCL)) were centered in the supraglottic region involved the glottis (3/3) and subglottic (1/3). Two cases (MALT) were centered in the glottis involved the subglottic. The laryngeal tumors involved the true cords (5 cases), aryepiglottic folds (3 cases), ventricles and false cords (3 cases), anterior commissure (2 cases). On MRI (4 cases), all NHL presenting as homogeneous intermediate T1-weighted, heterogeneous slightly high T2-weighted mass with homogeneous moderate to evident enhancement. The mucosa with more obvious enhancement and smooth surface could be seen. On CT (1 plain and 3 contrast-enhanced), all tumors were homogeneous moderate density, and no necrosis or calcifications were seen. Lymphadenopathy was presented in two patients of DLBCL without necrosis. Conclusions On MRI or CT, when the laryngeal mass is located under the mucosa with uniform density or signal intensity, smooth surface, moderate to obvious homogeneous enhancement without cystic, necrosis, calcification and cartilage destruction, the radiologist should consider that it is likely to be NHL, especially when the mass spreads upwards to the oropharynx, nasopharynx and Webster's lymphoid ring. Further studies however are needed to confirm our findings obtained in a limited number of patients.

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Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings

Cited by 14 publications

References 29 publications

Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

A Case of Laryngeal Tuberculosis Mimicking Lymphoma

Imaging Characteristics of Primary Non-Hodgkin's Lymphoma of The Larynx

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