Non-stenosing Carotid Atherosclerosis and Arterial Stiffness in Embolic Stroke of Undetermined Source

Acampa, Maurizio; Lazzerini, Pietro Enea; Manfredi, Chiara; Guideri, Francesca; Tassi, Rossana; Domenichelli, Carlo; Cartocci, Alessandra; Martini, Giuseppe

doi:10.3389/fneur.2020.00725

Cited by 8 publications

(4 citation statements)

References 25 publications

(30 reference statements)

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“…Third, aortic stiffness and wave reflection are associated with poor left ventricular conditions, which may increase the risk of poor outcomes 34 . Fourth, aortic stiffness is linked to atherosclerosis because both share several risk factors, including hypertension 35 . The current study showed that hypertension was common in 72.5% of patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of central blood pressure on the outcomes of embolic stroke of undetermined source

Han

Heo

Lee

et al. 2023

Sci Rep

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We investigated the prognostic impact of central blood pressure (BP) on outcomes in patients with embolic stroke of undetermined source (ESUS). The prognostic value of central BP according to ESUS subtype was also evaluated. We recruited patients with ESUS and data on their central BP parameters (central systolic BP [SBP], central diastolic BP [DBP], central pulse pressure [PP], augmentation pressure [AP], and augmentation index [AIx]) during admission. ESUS subtype classification was arteriogenic embolism, minor cardioembolism, two or more causes, and no cause. Major adverse cardiovascular event (MACE) was defined as recurrent stroke, acute coronary syndrome, hospitalization for heart failure, or death. Over a median of 45.8 months, 746 patients with ESUS were enrolled and followed up. Patients had a mean age of 62.8 years, and 62.2% were male. Multivariable Cox regression analysis showed that central SBP and PP were associated with MACE. All-cause mortality was independently associated with AIx. In patients with no cause ESUS, central SBP and PP, AP, and AIx were independently associated with MACE. AP and AIx were independently associated with all-cause mortality (all p < 0.05). We demonstrated that central BP can predict poor long-term prognosis in patients with ESUS, especially those with the no cause ESUS subtype.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of central blood pressure on the outcomes of embolic stroke of undetermined source

Han

Heo

Lee

et al. 2023

Sci Rep

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“…Both ALDH2 and MRVI1 are involved in platelet adhesion [ 47 ] and vascular inflammation [ 48 , 49 ]. Previous research has linked increased blood-brain barrier permeability to an inflammatory process involving activated monocytes/macrophages in individuals with cerebral small vessel disease [ 50 , 51 ]. In our study, MRVI1 was more abundant in astrocytes, which supports their roles in vascular inflammation.…”

Section: Discussionmentioning

confidence: 99%

Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

Zhang

Qin

et al. 2022

BMC Med

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Background Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analytical pipeline to efficiently transform genetic associations to identify novel proteins for lacunar stroke. Methods We systematically integrated lacunar stroke genome-wide association study (GWAS) (N=7338) with human brain proteomes (N=376) to perform proteome-wide association studies (PWAS), Mendelian randomization (MR), and Bayesian colocalization. We also used an independent human brain proteomic dataset (N=152) to annotate the new genes. Results We found that the protein abundance of seven genes (ICA1L, CAND2, ALDH2, MADD, MRVI1, CSPG4, and PTPN11) in the brain was associated with lacunar stroke. These seven genes were mainly expressed on the surface of glutamatergic neurons, GABAergic neurons, and astrocytes. Three genes (ICA1L, CAND2, ALDH2) were causal in lacunar stroke (P < 0.05/proteins identified for PWAS; posterior probability of hypothesis 4 ≥ 75 % for Bayesian colocalization), and they were linked with lacunar stroke in confirmatory PWAS and independent MR. We also found that ICA1L is related to lacunar stroke at the brain transcriptome level. Conclusions Our present proteomic findings have identified ICA1L, CAND2, and ALDH2 as compelling genes that may give key hints for future functional research and possible therapeutic targets for lacunar stroke.

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“…Due to physiological change from person to person the glucose level also altered among them and hyperglycemia can cause quick response to initiate macro complication. HbA1c is an accurate and precise measuring tool to diagnose chronic blood glucose levels and is more closely related to the complications risk than episodic or single glucose measurements [17]. Socioeconomic levels also considered as risk factor among the diabetes patients.…”

Section: Discussionmentioning

confidence: 99%

Study to Determine the Incidence of High HbA1c in Patients with Ischemic Stroke at Bilawal Medical College, Kotri, Sindh, Pakistan

Ahmed

Poorani

Kalhoro

et al. 2021

JPRI

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Aim: To study the incidence of HbA1c elevation in patients with ischemic stroke whose blood glucose levels were normal within the last six months. Study Design: A cross-sectional study. Place and Duration: This cross-sectional study of the 96 patients with cerebral ischemic disease selected from the internal medicine department of Bilawal medical college Hospital Kotri, Sindh, Pakistan for one-year duration from August 2019 to August 2020. Methods: Crossectional study was conducted in the internal medicinal department of Bilawal Medical college Hospital, Kotri Sindh, Pakistan for the period of one year from August 2019 to August 2020. Total 96 study subjects were selected with cerebral ischemic disease, 62 were males and 34 were females. Many factors such as age more than 20 years, ischemic stroke and RBG (Random Blood Glucose) were also evaluated from each participant. SPSS 23.00 version was used for statistical analysis of research data. Results: 57.01 ± 13.4 years was the mean age of the patients. 62 (64.6%) patients were male and 34 (35.4%) were female. The male to female ratio was 2:1. HbA1c was elevated in 35 (36.5%) of 96 patients, while 61 (63.5%) had normal HbA1c. The distribution of HbA1c elevation by gender showed that 20 (57.1%) patients with elevated HbA1c were men and 15 (42.9%) were women. Forty-three (70.5%) of 61 patients with normal HbA1c were male and 18 (29.5%) were female. Conclusion: it was concluded that glycated haemoglobin plays an important role for reducing the macro complication of Diabetes and the major macro complication observed was cerebral ischemic stroke among the people with elevated HbA1c.

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Non-stenosing Carotid Atherosclerosis and Arterial Stiffness in Embolic Stroke of Undetermined Source

Cited by 8 publications

References 25 publications

Prognostic value of central blood pressure on the outcomes of embolic stroke of undetermined source

Prognostic value of central blood pressure on the outcomes of embolic stroke of undetermined source

Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

Study to Determine the Incidence of High HbA1c in Patients with Ischemic Stroke at Bilawal Medical College, Kotri, Sindh, Pakistan

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