Non-steroidal Anti-inflammatory Drug-induced Acute Pancreatitis: A Case Report

Reyes, Jonathan Vincent M.; Patel, Bhavin; Malik, Fahad; Gonzalez, Manuel O.

doi:10.7759/cureus.5926

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The majority of the effects mentioned in these research support and partially agree with the findings of current data. According to Reyes et al (16) , a patient who used ibuprofen every day for three weeks to manage chronic shoulder pain developed acute pancreatitis. The majority of NSAIDs have been linked to acute pancreatitis, although sulindac is the most wellknown of all of them (17) .…”

Section: Discussionmentioning

confidence: 99%

Histological Studies on The Effect of Diclofenac Sodium on The Foetal Pancreas of Albino Mice

Sabry¹

2022

The Egyptian Journal of Hospital Medicine

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Background: Diclofenac sodium (DS) is regarded as one of the most significant and often used medications. Numerous cases of rheumatoid arthritis, osteoarthritis and soft tissue rheumatism are all treated with it. Despite the drug's positive effects, some medical studies accuse it of having pathogenic effects after being used for medicinal purposes on the body's organs. Objective: The purpose of the current research was to assess the histological impact of the non-steroidal antiinflammatory drug, diclofenac sodium (DS) on the pancreas of albino mice foetuses. Material and methods: Six groups of 60 pregnant female mice were prepared (10 mice each). Each animal in the first and second groups received an intraperitoneal (IP) injection of the drug's solvent every day for six days, from day 1 till day 6 of gestation (GDs 1-6) and from day 7 to day 14 of gestation (GDs 7-14), respectively. These groups served as the control groups. The third and five groups are the treated groups, receiving daily (IP) injections of 1.5 and 3 mg/kg body weight of DS from days 1 through 6 of gestation (GDs 1-6), respectively, whereas the animals in groups fourth and six received similarly daily injections of 1.5 and 3 mg/kg body weight of DS for 8 days (GDs 7-14), respectively. Results: The pancreas of maternally treated foetuses underwent histological study, which revealed signs of alteration in both the exocrine and endocrine structures. These features varied according to the dose and period of administration, and they included focal acinar damage that manifested as cytoplasmic vacuolation and necrosis, pyknotic, and karyolysed nuclei, as well as blood extravasations that revealed hemorrhagic appearances. Conclusion: Because of the damaging effects of DS on the developing pancreas of mice, it should only be administered under rigorous control in the medical profession to safeguard expectant mothers from its potentially harmful effects.

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Section: Discussionmentioning

confidence: 99%

Histological Studies on The Effect of Diclofenac Sodium on The Foetal Pancreas of Albino Mice

Sabry¹

2022

The Egyptian Journal of Hospital Medicine

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“…This suspicious increase of the dosage of this nonsteroidal anti-inflammatory drug (NSAID) in combination with the lack of other known inciting etiologies which may contribute to pancreatitis helped determine that a drug-induced mechanism was likely the etiology. Although the mechanism to explain why NSAIDs may be implicated in acute pancreatitis has not been thoroughly confirmed, there has been speculation that NSAIDs may cause a lack of appropriate response directed against oxidative stress secondary to a reduction in systemic glutathione that results from decreased superoxide dismutase activity, as well as a possible destabilization effect of the NSAID on the pancreatic cell membrane secondary to their effects on prostaglandins [ 4 ]. A direct hypersensitivity and/or immune-mediated response directly from the NSAID in a particular individual who developed drug-induced pancreatitis cannot be completely ruled out [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Meloxicam-Induced Pancreatitis

Landa¹,

Ganim²,

Vigandt³

et al. 2021

Cureus

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There are 525 drugs that have been identified by the World Health Organization (WHO) as having the potential to cause pancreatitis. The most well-known drugs include mesalamine, azathioprine, and simvastatin, all of which have been well described in the literature. However, drug-induced pancreatitis only used to account for about 1%-2% of cases in the 1990s; this number has increased to up to 5% in some studies. By accounting for over 100,000 cases per year in the United States alone, it is important to be able to recognize these cases and act rapidly and appropriately to remove the offending agent. The vast majority of cases occur within six weeks of initiating or increasing the dosage of such medications. Here we present an interesting case of meloxicam-induced pancreatitis.

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“…Finally, drugs, including NSAIDs, steroids, and tocilizumab, are a significant factor in the multifactorial pathophysiology of pancreatic injury, adding complexity to the diagnosis of SARS-CoV-2 involvement in AP aetiology [60][61][62]. Several reports have been published showing that these drugs may directly or indirectly result in AP [63][64][65][66].…”

Section: Pathophysiological Mechanismsmentioning

confidence: 99%

Pancreatic and Hepatic Injury in COVID-19: A Worse Prognosis in NAFLD Patients?

Mengual-Moreno,

Nava,

Manzano

et al. 2024

Biomedicines

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The novel disease produced by SARS-CoV-2 mainly harms the respiratory tract, but it has shown the capacity to affect multiple organs. Epidemiologic evidence supports the relationship between Coronavirus Disease 2019 (COVID-19) and pancreatic and hepatic injury development, identified by alterations in these organ function markers. In this regard, it is important to ascertain how the current prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) might affect COVID-19 evolution and complications. Although it is not clear how SARS-CoV-2 affects both the pancreas and the liver, a multiplicity of potential pathophysiological mechanisms seem to be implicated; among them, a direct viral-induced injury to the organ involving liver and pancreas ACE2 expression. Additionally, immune system dysregulation, coagulopathies, and drugs used to treat the disease could be key for developing complications associated with the patient’s clinical decline. This review aims to provide an overview of the available epidemiologic evidence regarding developing liver and pancreatic alterations in patients with COVID-19, as well as the possible role that NAFLD/NASH might play in the pathophysiological mechanisms underlying some of the complications associated with COVID-19. This review employed a comprehensive search on PubMed using relevant keywords and filters. From the initial 126 articles, those aligning with the research target were selected and evaluated for their methodologies, findings, and conclusions. It sheds light on the potential pathophysiological mechanisms underlying this relationship. As a result, it emphasises the importance of monitoring pancreatic and hepatic function in individuals affected by COVID-19.

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Non-steroidal Anti-inflammatory Drug-induced Acute Pancreatitis: A Case Report

Cited by 4 publications

References 8 publications

Histological Studies on The Effect of Diclofenac Sodium on The Foetal Pancreas of Albino Mice

Histological Studies on The Effect of Diclofenac Sodium on The Foetal Pancreas of Albino Mice

Meloxicam-Induced Pancreatitis

Pancreatic and Hepatic Injury in COVID-19: A Worse Prognosis in NAFLD Patients?

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