Non-steroidal anti-inflammatory drugs as a possible cause of collagenous colitis: a case-control study.

Abstract

Purpose: Enhanced tumor cell survival through expression of inhibitors of apoptosis (IAP) is a hallmark of cancer. Survivin, an IAP absent from most normal tissues, is overexpressed in many malignancies and associated with a poorer prognosis. We report the first-in-human dose study of LY2181308, a secondgeneration antisense oligonucleotide (ASO) directed against survivin mRNA.Patients and Methods: A dose-escalation study evaluating the safety, pharmacokinetics, and pharmacodynamics of LY2181308 administered intravenously for 3 hours as a loading dose on 3 consecutive days and followed by weekly maintenance doses. Patients were eligible after signing informed consent, had exhausted approved anticancer therapies and agreed to undergo pre-and posttreatment tumor biopsies to evaluate reduction of survivin protein and gene expression.Results: A total of 40 patients were treated with LY2181308 at doses of 100 to 1,000 mg. Twenty-six patients were evaluated at the recommended phase 2 dose of 750 mg, at which level serial tumor sampling and

Colitis microscópica: Un diagnóstico a tener en cuenta en caso de diarrea secretora

“…En cuanto a la etiología, los distintos autores han querido implicar, factores autoinmunitarios (11), toxinas bacterianas (como la toxina del Cl difficile) (12,13) y el consumo de algunos fármacos, tales como lansoprazol, simvastatina, ticlopidina, flutamida (14-16) y los antinflamatorios no esteroideos (AINES). Referidos a éstos últimos se ha encontrado alguna evidencia de asociación entre su consumo y la incidencia de colitis colágena (17); si bien es cierto que otros trabajos más recientes parecen descartar esta asociación (18,19). Por otra parte en los últimos años se ha sugerido una relación etiológica entre la colitis microscópica y la enfermedad celíaca, debido a la concurrencia descrita de esta última patología sobre todo con la colitis linfocítica (20).…”

The Differential Diagnosis of Colitis in Endoscopic Biopsy Specimens: A Review Article

“…12,13 There also appears to be a strong association with NSAID use. 14 Colonoscopy yields normal or near normal mucosa, although there are a few reports of linear mucosal tears that were thought to occur upon insufflation during endoscopy. 15 In addition, there are rare reports of CC with pseudomembranes.…”

NSAID-induced Collagenous Colitis: Figure 1.

“…The length of NSAID use before the development of symptoms of CC ranges from weeks 3 to over 15 years 4 , with the average being 5.5 years 5 . The duration of time to resolution of symptoms also varies, from days 6 to several months 2,7,8 .…”