Non-steroidal anti-inflammatory drugs disrupt the heat shock response in rainbow trout

The nonsteroidal anti-inflammatory drug, ibuprofen, affects the immune parameters in the clam Ruditapes philippinarum

“…The in vivo exposure of freshwater mussels (D. polymorpha) to IBU also induced significant destabilisation of lysosomal membranes in an overall time-dependent and dosedependent manner (Parolini et al, 2011). IBU was also shown to significantly increase LDH activity in the liver from the rainbow trout, Oncorhynchus mykiss, suggesting enhanced tissue glycolytic capacity of the contaminant (Gravel and Vijayan, 2007). With regard to other PPCPs, a significant release of LDH was recorded in clams exposed to TCS, indicating that the plasma membrane is a prime site for the toxic action of TCS (Matozzo et al, 2012).…”

Early Life-Stage Toxicity of Eight Pharmaceuticals to the Fathead Minnow, Pimephales promelas

“…However, no change in survival, growth, or incidence in abnormalities were observed in FHM larvae at the concentrations tested in this study. Ibuprofen alters the pattern of reproduction in medaka and the heat-shock response in trout (Flippin et al 2007;Gravel & Vijayan 2007). Studies with zebrafish and the nonspecific COX inhibitor diclofenac demonstrated that normal fish development was not impacted after exposure to 2000 lg/L (Hallare et al 2004).…”

Effect of salicylic acid on early life stages of common carp (Cyprinus carpio)

“…Regarding the effects of salicylates, Zivna et al (2013) see the reason for increased body weight and growth rate on the release of several important hormones influencing homeostasis in fish, a phenomenon which has been described in many studies (Van Anholt et al, 2003;Gravel and Vijayan, 2007a;Gravel and Vijayan, 2007b;Gravel et al, 2009). It has also been demonstrated that salicylates may regulate plant growth and productivity (Hayat et al, 2010).…”