Non-steroidal anti-inflammatory drugs: Effects on the utilization of glucose and production of lactic acid in tissue culture

Wolná, E; Inglot, Anna D.

doi:10.1007/bf01913258

Cited by 9 publications

(1 citation statement)

References 9 publications

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“…The N-aromatic amides of the 5-benzoyl derivative of amino acid 1 predominately displayed this type of activity in previous tests [35]. Here, in the tested 5-(4-chlorobenzoyl) derivatives, derivative 21 had the highest activity (EC 50 : 2.9 l 0.6 lM); i. e. the lowest EC 50 , the concentration at which relative hemolysis equals half of the control value (Table 4) …”

Section: Membrane Stabilizationmentioning

confidence: 80%

New Isothiazole Derivatives: Synthesis, Reactivity, Physicochemical Properties and Pharmacological Activity

Regiec

Machoń

Międzybrodzki

et al. 2006

Archiv der Pharmazie

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The synthesis and biological investigation of the series of amide and ester derivatives 10-20 of 5-(4-chlorobenzoyl)amino-3-methyl-4-isothiazolecarboxylic acid 5 are presented. Because the amide series of 5-benzoylamino-3-methyl-4-isothiazolecarboxylic acid 2 has been studied extensively and from this series denotivir (vratizolin) 4 became the antiviral drug. The influence of exchanging the N-benzoyl for a N-(4-chlorobenzoyl) group at position 5 of the isothiazole ring on the pharmacological activity of 5-benzoylamino-3-methyl-4-isothiazolecarboxylic acid 2 derivatives is dealt with here. The effect of structure modifications in the carboxylic group of the 5-(4-chlorobenzoyl)amino-3-methyl-4-isothiazolecarboxylic acid 5 series of derivatives on their biological activity is discussed. Some of the tested 5-(4-chlorobenzoyl)amino-3-methyl-4-isothiazolecarboxylamides revealed significant anti-inflammatory activity in carrageenan induced edema and air-pouch inflammation tests. Physicochemical properties of 6-(4-chlorophenyl)-3-methylisothiazolo[5,4-d]-4H-1,3-oxazin-4-one 6 are described. Its use in the synthesis of isothiazole derivatives and its reactivity are also presented.

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Section: Membrane Stabilizationmentioning

confidence: 80%

New Isothiazole Derivatives: Synthesis, Reactivity, Physicochemical Properties and Pharmacological Activity

Regiec

Machoń

Międzybrodzki

et al. 2006

Archiv der Pharmazie

View full text Add to dashboard Cite

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Screening and Assessment of the Potency of Anti-Inflammatory Drugs in vitro

Gryglewski¹

1979

Handbook of Experimental Pharmacology

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Effect on non-steroidal anti-inflammatory drugs on Moloney sarcoma virus inoculated mice

Inglot

Oleszak

1978

Experientia

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Chronic administration of phenylbutazone, flufenamic acid and a new, potent non-steroidal anti-inflammatory agent ITF (3-methyl-5-benzoyl-amino-isothiazole-4-carboxy-p-ethoxyphenylamine) to BALB/c mice inoculated with a Moloney sarcoma virus resulted in a stimulation of tumor growth and increased severity of disease. This treatment, however, had no effect on the spontaneous regression of tumors. Indomethacin in a dose of 5.0 or 2.5 mg per kg suppressed the MSV-induced tumor growth, but this effect was apparently connected with the high toxicity of this drug for mice.

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Non-steroidal anti-inflammatory drugs: Effects on the utilization of glucose and production of lactic acid in tissue culture

Cited by 9 publications

References 9 publications

New Isothiazole Derivatives: Synthesis, Reactivity, Physicochemical Properties and Pharmacological Activity

New Isothiazole Derivatives: Synthesis, Reactivity, Physicochemical Properties and Pharmacological Activity

Screening and Assessment of the Potency of Anti-Inflammatory Drugs in vitro

Effect on non-steroidal anti-inflammatory drugs on Moloney sarcoma virus inoculated mice

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