Non‐steroidal anti‐inflammatory drugs have bacteriostatic and bactericidal activity against <i>Helicobacter pylori</i>

Shirin, Haim; Moss, Steven F.; Kancherla, Sandy; Kancherla, Kevin; Holt, Peter R.; Weinstein, I. Bernard; Sordillo, Emilia Mia

doi:10.1111/j.1440-1746.2006.04194.x

Cited by 38 publications

(23 citation statements)

References 34 publications

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“…Previous studies have suggested that NSAIDs including aspirin possess bacteriostatic activity against H. pylori in vitro with the minimum inhibitory concentration (MIC) of 100 µg/mL [25][26][27]. However, the present study showed that there was no apparent difference in the bacterial density in gastric mucosa 36 weeks after inoculation of H. pylori between Mongolian gerbils with and without 34week aspirin treatment, suggesting that the aspirin doses (150 and 500 p.p.m.)…”

Section: Discussioncontrasting

confidence: 80%

Effects of Aspirin on the Development of Helicobacter pylori‐Induced Gastric Inflammation and Heterotopic Proliferative Glands in Mongolian Gerbils

Xia

Chen

et al. 2008

Helicobacter

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Section: Discussioncontrasting

confidence: 80%

Effects of Aspirin on the Development of Helicobacter pylori‐Induced Gastric Inflammation and Heterotopic Proliferative Glands in Mongolian Gerbils

Xia

Chen

et al. 2008

Helicobacter

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“…[7] Further, there have been reports of anti H. pylori effects of salicylates and sulindac; their effects on the result of RUT are, however, not yet clear. [8]…”

mentioning

confidence: 99%

Accuracy of rapid urease test in diagnosing Helicobacter pylori infection in patients using NSAIDs

Foroutan

Loloei

Irvani

et al. 2010

Saudi J Gastroenterol

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Background/Aim:This study aimed to determine the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the results of rapid urease test (RUT).Patients and Methods:The study evaluated 210 consecutive patients for the diagnosis of Helicobacter pylori (H. pylori) infection. They were divided into case and control groups based on history of NSAID use (n=70 each). Two biopsy specimens were collected from antrum and corpus of stomach during endoscopy and sent for rapid urease testing and histopathology. Sensitivity, specificity, and accuracy rate of RUT test were compared against histology.Results:The average age was 55.2±12.9 and 43.3±12.1 years in the case and control groups, respectively. Among NSAID users, RUT sensitivity, specificity and accuracy rate were all 100%. The sensitivity, specificity and accuracy rate of RUT in patients without history of NSAID use were 97.37, 98.57 and 98.14%, respectively. The overall sensitivity, specificity and accuracy rate of RUT were 98.57, 99.29, and 99.04%, respectively.Conclusion:Our study shows that sensitivity, specificity and accuracy rate of RUT are not affected by NSAID use. Rapid urease test remains a reliable test for diagnosis of H. pylori in patients on NSAIDs.

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“…Previous studies hypothesized that aspirin and NSAIDs could inhibit H. pylori growth in vitro and increase its susceptibility to antibiotics [25, 26]. A small Korean study compared the efficacy of the standard omeprazole–amoxicillin–clarithromycin (OAC) regimen (61 cases) with the OAC plus aspirin regimen (60 cases) and did not find a significant difference in eradication rates (per protocol analysis: 80.3% vs. 86.7%, p = 0.472) [25]. Recently, Zhang et al.…”

Section: Discussionmentioning

confidence: 99%

Randomized trial comparing rabeprazole‐ versus lansoprazole‐based Helicobacter pylori eradication regimens

Liu

et al. 2013

The Kaohsiung J of Med Scie

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Different types of proton pump inhibitor (PPI)-based triple therapies could result in different Helicobacter pylori eradication rates. This study aimed to compare the efficacy and safety of rabeprazole- and lansoprazole-based triple therapies in primary treatment of H. pylori infection. From September 2005 to July 2008, 426 H. pylori-infected patients were randomly assigned to receive a 7-day eradication therapy with either rabeprazole 20mgbid (RAC group, n=222) or lansoprazole 30mgbid (LAC group, n=228) in combination with amoxicillin 1gbid and clarithromycin 500mgbid. The patients received follow-up esophagogastroduodenoscopy (EGD) and/or (13)C-urea breath test 12-16 weeks later to define H. pylori status. Their personal and medical history, compliance and side effects were obtained by using a standardized questionnaire. Intention-to-treat analysis revealed that the eradication rate was 87.84% in the RAC group and 85.96% in the LAC group (p=0.56). All patients returned for assessment of compliance (100% in the LAC group vs. 99.50% in the RAC group; p=0.32) and adverse events (7.20% in the RAC group vs. 5.70% in the LAC group, p=0.51). Univariate analysis suggested that patients with nonsteroid anti-inflammatory agent (NSAID) use had lower eradication rates than those without (76.71% vs. 88.74%; p=0.006). Our results showed that efficacy and safety were similar in rabeprazole- and lansoprazole-based primary therapies. The influence of NSAID usage on H. pylori eradication needs to be further investigated.

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Non‐steroidal anti‐inflammatory drugs have bacteriostatic and bactericidal activity against Helicobacter pylori

Abstract: The decreased prevalence of Helicobacter pylori in specimens from some NSAID users and the chemopreventive effects of NSAIDs in gastric cancer may be related to inhibition of Helicobacter pylori growth.

Cited by 38 publications

References 34 publications

Effects of Aspirin on the Development of Helicobacter pylori‐Induced Gastric Inflammation and Heterotopic Proliferative Glands in Mongolian Gerbils

Effects of Aspirin on the Development of Helicobacter pylori‐Induced Gastric Inflammation and Heterotopic Proliferative Glands in Mongolian Gerbils

Accuracy of rapid urease test in diagnosing Helicobacter pylori infection in patients using NSAIDs

Randomized trial comparing rabeprazole‐ versus lansoprazole‐based Helicobacter pylori eradication regimens

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