Non-steroidal anti-inflammatory drugs initiate morphological changes but inhibit carotenoid accumulation in Haematococcus pluvialis

Bácsi, István; Deli, József; Gonda, Sándor; Mészáros, Ilona; Veréb, Gréta; Dobronoki, Dalma; Nagy, S.; B‐Béres, Viktória; Vasas, Gábor

doi:10.1016/j.algal.2018.01.007

Cited by 11 publications

(4 citation statements)

References 72 publications

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“…Diclofenac (DCF), at 60–72 mg/L, caused 50% inhibition of Desmodesmus subspicatus growth [127,134], but at 147 mg/L, caused 50% inhibition of photosynthetic activity in D. subspicatus culture [84]. In another study, diclofenac, within a concentration range of 29–53 mg/L, caused 50% inhibition of Haematococcus pluvialis vegetative cell culture, and a negative effect on growth was pronounced with elongation of cultivation (up to 14 days) [135]. DCF, within 10–65 mg/L, caused 50% inhibition of Pseudokirchneriella subcapitata growth [82,115,136,137]; at 134 mg/L, caused 50% inhibition of Chlamydomonas reinhardtii population density growth [138]; at 60–150 mg/L, caused ≥30% inhibition of Chlorella pyrenoidosa biomass production/growth [107]; and at 185 mg/L, caused 50% toxicity to Dunaliella tertiolecta [139].…”

Section: Inhibitory Effect Of Pharmaceuticals and Personal Care Prmentioning

confidence: 99%

“…Chlorophyll a / b ratio could be also decreased (20% increase in Chl b ) in Pseudokirchneriella subcapitata cells treated with drugs [226]. Moreover, a decrease (by up to 50%) in carotenoid content and a drop to zero in astaxanthin content was observed in Haematococcus pluvialis cells exposed to diclofenac (at 75–100 mg/L) [135].…”

Section: Effect Of Pharmaceuticals and Personal Care Products On Mmentioning

confidence: 99%

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Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review

Miazek

Brożek-Płuska

2019

IJMS

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In this review, the effect of pharmaceuticals (PHRs) and personal care products (PCPs) on microalgal growth and metabolism is reported. Concentrations of various PHRs and PCPs that cause inhibition and toxicity to growths of different microalgal strains are summarized and compared. The effect of PHRs and PCPs on microalgal metabolism (oxidative stress, enzyme activity, pigments, proteins, lipids, carbohydrates, toxins), as well as on the cellular morphology, is discussed. Literature data concerning the removal of PHRs and PCPs from wastewaters by living microalgal cultures, with the emphasis on microalgal growth, are gathered and discussed. The potential of simultaneously bioremediating PHRs/PCPs-containing wastewaters and cultivating microalgae for biomass production in a single process is considered. In the light of reviewed data, the feasibility of post-bioremediation microalgal biomass is discussed in terms of its contamination, biosafety and further usage for production of value-added biomolecules (pigments, lipids, proteins) and biomass as a whole.

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Section: Inhibitory Effect Of Pharmaceuticals and Personal Care Prmentioning

confidence: 99%

Section: Effect Of Pharmaceuticals and Personal Care Products On Mmentioning

confidence: 99%

Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review

Miazek

Brożek-Płuska

2019

IJMS

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“…The main carotenoid components (lutein/zeaxanthin, astaxanthin-esters and β-carotene) were separated and their amounts per dry weight were estimated by thin layer chromatography (TLC). For the TLC analysis, pigments were transferred from DMSO to ethyl-acetate according to Du et al (2016) with modifications ( Bácsi et al, 2018 ). Aliquots of 20 μL of the DMSO-free ethyl-acetate phases were subjected to TLC plates (Silica gel 60 GF254 10 × 20 cm; Merck, Darmstadt, Germany).…”

Section: Methodsmentioning

confidence: 99%

Salinity tolerance and desalination properties of a Haematococcus lacustris strain from eastern Hungary

Bácsi,

Figler,

Simon

et al. 2024

Front. Microbiol.

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Nowadays the increasing amount of saline wastewaters has given rise to various biological desalination processes, among which the application possibilities of microalgae represents a priority research area. Next to “real” aquatic species (members of phytoplankton or phytobenthon), species from ephemeral aquatic habitats or aeroterrestrial algae also could be good candidates of research studying salt tolerance or desalination ability, since salinity stress is often referred as “physiological drought” and species from ephemeral habitats can be characterized by high drought tolerance. In this study, the salinity tolerance, salt and nutrient removal ability of a Haematococcus lacustris strain from eastern Hungary were investigated. Vegetative cells showed low salt tolerance, survival was ensured by the formation of cysts up to a sodium-chloride concentration of 2,000 mg l−1. Although relatively moderate (a max. 30%) conductivity reduction and chloride removal were observed, notable (nearly 100%) nitrate and phosphate removal occurred even in the presence of 2,000 mg l−1 NaCl. Carotenoid accumulation was observed earlier and in higher extent in salt treated cultures than in drying out ones, although the amount of astaxanthin-esters was significantly higher in the cultures of drying out experiment than in the corresponding cultures of salt treatment characterized with similar chloride content. Our results suggest that algae isolates from ephemeral aquatic habitats endangered by regular drying out (exposed to special salt stress), could have notable salt tolerance and consequently successful applicability in nutrient removal processes from slightly saline wastewaters. The accumulation of valuable metabolites (such as astaxanthin) as a response to salinity stress, could enhance the economic value of the biomass.

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“…Another widely studied emerging contaminant is the anti-inflammatory drug diclofenac (DCF), which belongs to the family of aryl alkanoic acids, namely, 2-[2-(2,6-dichloranilino) phenyl] acetic acid. Diclofenac is an analgesic and antipyretic for treating rheumatic diseases and against infectious processes followed by inflammation (Bácsi et al 2018 ). The half-life of DCF is approximately 2 h, and it is excreted in a short period.…”

Section: Introductionmentioning

confidence: 99%

Emerging contaminants in the aquatic environment: phytoplankton structure in the presence of sulfamethoxazole and diclofenac

Duarte

Ribeiro

Carvalho

et al. 2023

Environ Sci Pollut Res

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Chemicals from anthropogenic activities such as domestic sewage, pesticide leaching, and improper chemical disposal have caused groundwater contamination. The presence of these emerging contaminants in the aquatic environment can change water quality and biota composition. Thus, this study investigates the effect of two emerging contaminants, anti-inflammatory drug diclofenac (DCF) and antibiotic sulfamethoxazole (SMX), on the aquatic environment, evaluating the phytoplankton community structure. A microcosm experiment was conducted with 16 sampling units, each one with 500 mL of water sample containing phytoplankton exposed to these drugs at different concentrations (0.1, 0.5, and 1.0 mg L −1 ). The experiment lasted 15 days, and samples were collected on days 0, 3, 5, 7, and 14 to evaluate the phytoplankton community, the concentrations of the drugs, and the nutrients in the samples. Six phytoplankton groups were identified, and diatoms and green algae were the most diverse and abundant groups. For the entire community, we identified differences between the days of the experiment, varying in the diversity and density of organisms, but not between the concentrations of the two drugs. Evaluating the groups separately, we identified differences in the abundance of cyanobacteria for the treatment with diclofenac and desmids for the treatment with sulfamethoxazole. We demonstrated that the presence of pharmaceuticals in freshwater ecosystems can somehow affect the phytoplankton community, especially the diversity and abundance of cyanobacteria and desmids. Therefore, our study indicates the importance of evaluating the presence of pharmaceuticals in freshwater ecosystems and their influence on aquatic organisms, as well as pharmaceuticals may be changing the structure of the aquatic environment.

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Non-steroidal anti-inflammatory drugs initiate morphological changes but inhibit carotenoid accumulation in Haematococcus pluvialis

Abstract: Non-steroidal anti-inflammatory drugs initiate morphological changes but inhibit carotenoid accumulation in Haematococcus pluvialis.

Cited by 11 publications

References 72 publications

Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review

Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review

Salinity tolerance and desalination properties of a Haematococcus lacustris strain from eastern Hungary

Emerging contaminants in the aquatic environment: phytoplankton structure in the presence of sulfamethoxazole and diclofenac

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