Non-steroidal anti-inflammatory drugs, salicylates, and colitis

Gleeson, M. H.; Lim, Samuel; Spencer, Daniel I. R.

doi:10.1016/s0140-6736(96)91387-2

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…[25][26][27] In one study, cases of NSAID-associated colitis accounted for 10% of new colitis patients. 27,48 Given the overlap of histologic features in these entities and its high prevalence, it is important that pathologists consider NSAID-associated colitis before definitively diagnosing either Crohn disease or infectious-type colitis. The lack of crypt architectural distortion in all our cases suggests that NSAID-associated colitis, even when diffuse, is distinguishable histologically from ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

The Histopathology of Nonsteroidal Anti-inflammatory Drug-Associated Colitis

Goldstein

Cinenza

1998

Am J Clin Pathol

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Section: Discussionmentioning

confidence: 99%

The Histopathology of Nonsteroidal Anti-inflammatory Drug-Associated Colitis

Goldstein

Cinenza

1998

Am J Clin Pathol

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“…During the early 1990s in Jersey (UK), we noted a striking frequency of NSAID and salicylate usage in patients developing colitis 11 . In this paper, we present a case–control study of NSAID/salicylate exposure in such patients.…”

Section: Introductionmentioning

confidence: 94%

“…One hundred and five consecutive new cases of colitis were studied. The results of the first 49 patients have been reported briefly elsewhere 11 . The patients were all Jersey residents and three were of Portuguese origin (two NSAID colitics and one idiopathic colitic).…”

Section: Clinical Features and Endoscopic Distribution Of Colitismentioning

confidence: 99%

Non‐steroidal anti‐inflammatory drugs, aspirin and newly diagnosed colitis: a case–control study

Gleeson

Davis

2003

Aliment Pharmacol Ther

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SUMMARYBackground: There have been a number of reports of colitis following exposure to non-steroidal anti-inflammatory drugs (NSAIDs) and salicylates. Aim: To conduct a case-control analysis of new cases of colitis, with particular reference to the usage of NSAIDs and salicylates prior to the development of the disease. Methods: One hundred and five consecutive new cases of colitis presenting to a single gastroenterologist were questioned about their recent usage of NSAIDs and salicylates. For comparison, the frequency of usage of these compounds was studied in two groups of 105 ageand sex-matched controls taken from hospital in-patients and community cases attending the Accident and Emergency Department.

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“…The most recent metaanalysis also suggests that the risk disappears once the medication is discontinued [87] . Other frequently used types of drug that have also been associated with IBD are nonsteroidal anti-inflammatory drugs (NSAIDs) [88][89][90][91][92][93][94][95] . Due to their inhibitory action on protective prostaglandins, these drugs could enhance intestinal permeability facilitating disease activity.…”

Section: Oral Contraceptive and Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Familial aggregation in inflammatory bowel disease: Is it genes or environment?

Nunes

Fiorino

Danese

et al. 2011

WJG

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Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis.

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Non-steroidal anti-inflammatory drugs, salicylates, and colitis

Cited by 9 publications

References 3 publications

The Histopathology of Nonsteroidal Anti-inflammatory Drug-Associated Colitis

The Histopathology of Nonsteroidal Anti-inflammatory Drug-Associated Colitis

Non‐steroidal anti‐inflammatory drugs, aspirin and newly diagnosed colitis: a case–control study

Familial aggregation in inflammatory bowel disease: Is it genes or environment?

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