Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: From lab to clinic

Groot, Derk Jan A. de; Vries, de Elisabeth G. E.; Groen, Henk; Jong, de Steven

doi:10.1016/j.critrevonc.2006.07.001

Cited by 161 publications

(107 citation statements)

References 183 publications

(186 reference statements)

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“…Likewise, HDI-induced cell death can be augmented by inhibiting the antiapoptotic transcription factor NF-κB (24,25), whose activation is blocked by aspirin and salicylic acid (26,27). It is currently under discussion that salicylates and other NSAIDs in general may have synergistic efficacy when combined with anticancer agents (28,29). However, there are also a number of studies that suggest otherwise.…”

Section: Discussionmentioning

confidence: 99%

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells

Sonnemann

Hüls²,

Sigler³

et al. 2008

Oncol Rep

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Abstract. Histone deacetylase inhibitors (HDIs) as well as non-steroidal anti-inflammatory drugs including aspirin show promise as antineoplastic agents. The treatment with both HDIs and aspirin can result in hyperacetylation of proteins. In this study, we investigated whether HDIs and aspirin interacted in inducing anticancer activity and histone acetylation. We found that the HDIs, suberoylanilide hydroxamic acid and sodium butyrate, and aspirin cooperated to induce cell death in the ovarian cancer cell line, A2780. The effect was synergistic, as evidenced by CI-isobologram analysis. However, aspirin had no effect on histone acetylation, neither in the absence nor presence of HDIs. To gain insight into the mechanism underlying the synergistic action of HDIs and aspirin, we employed the deacetylated metabolite of aspirin, salicylic acid, and the cyclooxygenase-1-and -2-selective inhibitors, SC-560 and NS-398, respectively. We found that HDIs and salicylic acid interacted synergistically, albeit less efficiently than HDIs and aspirin, to induce cancer cell death, suggesting that the acetyl and the salicyl moiety contributed to the cooperative interaction of aspirin with HDIs. SC-560 and NS-398 had little effect both when applied alone or in conjunction with HDIs, indicating that the combinatorial effect of HDIs and aspirin was not the result of cyclo-oxygenase inhibition. In conclusion, our study demonstrates that HDIs and aspirin synergize to induce cancer cell death and, thus, provides a rationale for a more in-depth exploration into the potential of combining HDIs and aspirin as a strategy for anticancer therapy.

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Section: Discussionmentioning

confidence: 99%

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells

Sonnemann

Hüls²,

Sigler³

et al. 2008

Oncol Rep

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“…In this context, several combinations of COXIBs with other chemotherapeutic drugs and with novel molecular targeting compounds have been investigated. 35 However, to our knowledge, there is very little information about such strategies in HCC.…”

Section: Discussionmentioning

confidence: 99%

Novel combination of Celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells

et al. 2010

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“…For these reasons, the role of inflammatory and immune markers in augmenting the therapeutic effect of drugs on chronic inflammation associated diseases (CID) has attracted the attention of researchers (Dinarello 2010;Esser et al 2014). Antiinflammatory agents such as non-steroidal antiinflammatory drugs (NSAIDs) are successfully used in treating CID (Elizabeth et al 2009;Ridker & Lüscher 2014); however, the long-term use of these drugs may result in damage to the gastric intestinal mucosa, heart and kidney (de Groot et al 2007), thereby limiting their usage. A variety of plant extracts and their secondary metabolites exhibit a broad spectrum of anti-inflammatory and immunomodulatory activities with, to date, relatively few safety concerns (Aravindaram & Yang 2010;Recio et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords ''papaya'', ''anti-inflammatory and inflammation'' and ''immunomodulation and immune'' along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the antiinflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking. ARTICLE HISTORY

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Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: From lab to clinic

Cited by 161 publications

References 183 publications

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells

Novel combination of Celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells

Anti-inflammatory and immunomodulatory properties of Carica papaya

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