Non-sticky and antimicrobial zwitterionic nanocomposite dressings for infected chronic wounds

Huang, Kuan-Chun; Fang, Yi; Hsieh, Pai Shan; Li, Chun Chang; Dai, Niann Tzyy; Huang, Chun Jen

doi:10.1039/c7bm00039a

Cited by 44 publications

(18 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The comparison with other dressings such as AQUACEL® Ag (ConvaTec, Deeside, UK), showed faster‐wound healing in diabetic rats (15 days). Also, the pSBAA/Ag nanocomposite had bactericidal effects against S. epidermidis and P. aeruginosa in vitro [79].…”

Section: Resultsmentioning

confidence: 99%

Nanotechnology‐driven advances in the treatment of diabetic wounds

Zare

Rezayi

Aryan

et al. 2020

Biotechnology and Applied Biochemistry

View full text Add to dashboard Cite

Diabetic foot ulcers (DFUs) are chronic severe complications of diabetes disease and remain a worldwide clinical challenge with social and economic consequences. Diabetic wounds can cause infection, amputation of lower extremities, and even death. Several factors including impaired angiogenesis, vascular insufficiency, and bacterial infections result in a delayed process of wound healing in diabetic patients. Treatment of wound infections using traditional antibiotics has become a critical status. Thus, finding new therapeutic strategies to manage diabetic wounds is urgently needed. Nanotechnology has emerged as an efficient approach for this purpose. This review aimed to summarize recent advances using nanotechnology for the treatment of diabetic wounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Nanotechnology‐driven advances in the treatment of diabetic wounds

Zare

Rezayi

Aryan

et al. 2020

Biotechnology and Applied Biochemistry

View full text Add to dashboard Cite

show abstract

“…The experimental animals and were purchased from BioLASCO Taiwan Co., Ltd. The animal experiments were conducted referring to previous work 23 . Six female mice weighed 250–300 g were used in this study.…”

Section: Methodsmentioning

confidence: 99%

Intelligent Metal-Phenolic Metallogels as Dressings for Infected Wounds

Anh

Huang

2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

In this study, we report a metallogel developed based on metal-phenolic coordination of natural low-cost polyphenolic molecule and metal ions. Gelation occurs by mixing tannic acid (TA) and group (IV) titanium ions (Ti IV ) to form TA-Ti IV gel. The TA-Ti IV gel exhibits good capability to incorporate diverse metal ions by in situ co-gelation. Herein, five antimicrobial metal ions, i.e. ferric (Fe III ), copper (Cu II ), zinc (Zn II ), cobalt (Co II ) and nickel (Ni II ) ions, were employed to include in TA-Ti IV gels for developing intelligent dressings for infected wounds. The chemical and coordinative structures of TA-Ti IV metallogels were characterized by UV-Vis and Fourier-transform infrared (FT-IR) spectroscopies. Cytotoxicity of antimicrobial metallogels was explored by MTT assay with NIH 3T3 fibroblasts. The release of metal ions was evaluated by inductively coupled plasma mass spectrometry (ICP-MS), indicating the different releasing profiles upon the coordinative interactions of metal ions with TA. The formation and disassembly of metallogels are sensitive to the presence of acid and an oxidizer, H 2 O 2 , which are substances spontaneously generated in infected wounds due to the metabolic activity of bacteria and the intrinsic immune response. The Cu II releasing rates of TA-Ti IV -Cu II metallogels at different pH values of 5.5, 7.4 and 8.5 have been studied. In addition, addition of H 2 O 2 trigger fast release of Cu II as a result of oxidation of galloyl groups in TA. Consequently, the antimicrobial potency of TA-Ti IV -Cu II metallogels can be simultaneously activated while the wounds are infected and healing. The antimicrobial property of metallogels against Gram-negative Escherichia coli , and Gram-positive Methicillin-Resistant Staphylococcus aureus (USA300) and Staphylococcus epidermidis has been investigated by agar diffusion test. In an animal model, the TA-Ti IV -Cu II metallogels were applied as dressings for infected wounds, indicating faster recovery in the wound area and extremely lower amount of bacteria around the wounds, compared to TA-Ti IV gels and gauze. Accordingly, the intelligent nature derived metallogels is a promising and potential materials for medical applications.

show abstract

“…Nonetheless, Veegum HS ® reported to compromise Caco-2 viability from 160 µg/mL of clay (viability ≈50%) [31]. HT demonstrated to be more biocompatible than Veegum HS ® (Figure 6, left) [9,[11][12][13]31]. In view of the MTT results, 50 µg/mL was selected as the concentration to evaluate wound healing (Figure 6, right).…”

Section: Biocompatibility and Wound Healingmentioning

confidence: 99%

“…Nonetheless, the biocompatibility of hectorite natural clay mineral has been scarcely addressed. The majority of studies deal with synthetic hectorite-like clay minerals or functionalized natural hectorite [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hectorite/Spring Water Hydrogels as Wound Healing Products

García‐Villén

Sánchez-Espejo

Borrego-Sánchez

et al. 2020

The 1st International Electronic Conference on Pharmaceutics

View full text Add to dashboard Cite

Wound healing treatments continue to be a medical challenge, since complications usually lead to chronicization and comorbidities. Natural inorganic ingredients such as clays have been demonstrated to exert useful activities in this regard. Hectorite is a smectite clay with desirable rheology due to its layered structure and remarkable swelling capacity. These properties make it an appropriate excipient for semisolid systems. Nonetheless, the biocompatibility of natural hectorite has been scarcely addressed; the majority of studies centered on synthetic or functionalized hectorites. The aim of this study was to prepare and characterize a hectorite/spring water hydrogel. The hectorite clay mineral was subjected to a solid-state characterization, while the hydrogel (HTgel@10) was evaluated in terms of rheology, pH and in vitro biocompatibility and wound healing. Results demonstrated that the hectorite possessed a remarkable purity (84% w/w of hectorite), very similar to that of similar pharmaceutical excipients. HTgel@10 showed a non-Newtonian, viscoplastic to pseudoplastic profile and a stable pH for 12 months. In vitro tests reported that the hectorite and the HTgel@10 were biocompatible (cellular viability ≥ 70%). Specifically, the hectorite used in this study was more biocompatible toward fibroblasts than Veegum® HS. The in vitro wound healing test revealed that HTgel@10 was able to favor the wound closure. Therefore, hectorite/spring water hydrogels could be considered as potential wound healing formulations with remarkable stability and safety.

show abstract

Non-sticky and antimicrobial zwitterionic nanocomposite dressings for infected chronic wounds

Cited by 44 publications

References 54 publications

Nanotechnology‐driven advances in the treatment of diabetic wounds

Nanotechnology‐driven advances in the treatment of diabetic wounds

Intelligent Metal-Phenolic Metallogels as Dressings for Infected Wounds

Assessment of Hectorite/Spring Water Hydrogels as Wound Healing Products

Contact Info

Product

Resources

About