Non-sulphated cholecystokinin in human medullary thyroid carcinomas

Rehfeld, Jens F.; Johnsen, AH; Ødum, Lars; Bardram, Linda; Schifter, Søren; Scopsi, Lucio

doi:10.1677/joe.0.1240501

Cited by 33 publications

(30 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High levels of CCK have also been found in central nervous system neurons, where the peptide is thought to function as a neurotransmitter (2)(3)(4)(5)(6)(7). A syndrome due to ectopic production of CCK by specific tumors has not been described, although immunoreactive CCK peptides have been detected in aqueous extracts derived from a group of pituitary tumors and from 16 medullary thyroid tumors obtained at surgery (8,9). These observations suggest that CCK may be synthesized by specific groups of human neoplasms.…”

mentioning

confidence: 99%

Expression of the cholecystokinin gene in pediatric tumors.

Friedman

Vitale

Maimon

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

We have examined a wide range of cultured human tumor cell lines and found that a specific subset of tumors expresses the cholecystokinin (CCK) gene. All neuroepitheliomas (eight) and Ewing sarcoma (eight) cell lines that were tested express CCK RNA. In addition, two of six rhabdomyosarcoma cell lines also express the CCK gene, suggesting that rhabdomyosarcomas are probably heterogenous and that a subset may be similar to Ewing sarcoma and neuroepithelioma. Very few of the positive tumors express completely processed immunoreactive CCK. However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. These data demonstrate a consistent association of CCK gene expression with a specific group of human neoplasms. The data also add credence to the theory that Ewing sarcoma and neuroepithelioma are derived from the same transformed cell type. Finally, our results suggest that CCK gene expression may serve as a marker to distinguish these tumors, which are considered to be small-round-cell tumors of childhood, from other pediatric tumors.

show abstract

mentioning

confidence: 99%

Expression of the cholecystokinin gene in pediatric tumors.

Friedman

Vitale

Maimon

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Structurally, CCKs are defined as gallbladderemptying peptides having the C-terminal sequence Tyr-X 1 -X 2 -Trp-Met-Asp-Phe-NH 2, where X 1 in most mammals is a methionyl residue and X 2 a glycyl residue. Most bioactive CCK peptides are O-sulfated, but unsulfated CCK peptides also occur in normal tissue [17] and in tumor tissue [18], and they are natural agonists for the CCK B receptors.…”

Section: Definition Of the Cholecystokinin Family Of Peptidesmentioning

confidence: 99%

Cholecystokinin Expression in Tumors: Biogenetic and Diagnostic Implications

Rehfeld

2016

Future Oncol.

View full text Add to dashboard Cite

Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.

show abstract

“…CCK peptides are also widely expressed in peripheral neurons, primarily in the intestinal tract and also in the genitourinary tract and elsewhere (Larsson and Rehfeld 1979a, b;Rehfeld and Lundberg 1983). Low-level expression has been found in pituitary corticotrophs (Rehfeld 1986(Rehfeld , 1987, in thyroid C-cells (Rehfeld et al 1990), in the adrenal medulla , in the bronchial mucosa , and in the spermatogenic cells of certain mammals (Persson et al 1989).…”

Section: Procholecystokininmentioning

confidence: 99%

Cell-Specific Precursor Processing

Rehfeld

Bundgaard

2009

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

The singular gene for a peptide hormone is expressed not only in a specific endocrine cell type but also in other endocrine cells as well as in entirely different cells such as neurons, adipocytes, myocytes, immune cells, and cells of the sex-glands. The cellular expression pattern for each gene varies with development, time and species. Endocrine regulation is, however, based on the release of a given hormone from an endocrine cell to the general circulation from whose cappilaries the hormone reaches the specific target cell elsewhere in the body. The widespread expression of hormone genes in different cells and tissues therefore requires control of biogenesis and secretion in order to avoid interference with the function of a specific hormonal peptide from a particular endocrine cell. Several mechanisms are involved in such control, one of them being cell-specific processing of prohormones. The following pages present four examples of such cell-specific processing and the implications of the phenomenon for the use of peptide hormones as markers of diseases. Notably, sick cells - not least the neoplastic cells - often process prohormones in a manner different from that of the normal endocrine cells.

show abstract

Non-sulphated cholecystokinin in human medullary thyroid carcinomas

Cited by 33 publications

References 21 publications

Expression of the cholecystokinin gene in pediatric tumors.

Expression of the cholecystokinin gene in pediatric tumors.

Cholecystokinin Expression in Tumors: Biogenetic and Diagnostic Implications

Cell-Specific Precursor Processing

Contact Info

Product

Resources

About