2015
DOI: 10.3390/cancers7040891
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Non-Surgical Breast-Conserving Treatment (KORTUC-BCT) Using a New Radiosensitization Method (KORTUC II) for Patients with Stage I or II Breast Cancer

Abstract: The purpose of the present study was to establish a non-surgical breast-conserving treatment (BCT) using KORTUC II radiosensitization treatment. A new radiosensitizing agent containing 0.5% hydrogen peroxide and 0.83% sodium hyaluronate (a CD44 ligand) has been developed for intra-tumoral injection into various tumors. This new method, named KORTUC II, was approved by our local ethics committee for the treatment of breast cancer and metastatic lymph nodes. A total of 72 early-stage breast cancer patients (stag… Show more

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Cited by 20 publications
(34 citation statements)
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“…In previous publications as well as in our preliminary clinical experiences, the safety of KORTUC treatment has almost been established. (7)(8)(9)(10)(11)18) Intratumoral oxygen pressures at 1 or 24 h after H 2 O 2 -containing sodium hyaluronate injections were reported previously. (13) Oxygen pressures increased to 1400-1600 mmHg 1 h later and decreased to 80-100 mmHg at 24 h. Our CT study results seemed to be consistent with the previous results.…”
Section: Discussionmentioning
confidence: 76%
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“…In previous publications as well as in our preliminary clinical experiences, the safety of KORTUC treatment has almost been established. (7)(8)(9)(10)(11)18) Intratumoral oxygen pressures at 1 or 24 h after H 2 O 2 -containing sodium hyaluronate injections were reported previously. (13) Oxygen pressures increased to 1400-1600 mmHg 1 h later and decreased to 80-100 mmHg at 24 h. Our CT study results seemed to be consistent with the previous results.…”
Section: Discussionmentioning
confidence: 76%
“…In previous publications as well as in our preliminary clinical experiences, the safety of KORTUC treatment has almost been established. ()…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Furthermore, cCR was also confirmed through other diagnostic modalities performed during the follow-up period. Actually, the therapeutic effect was evaluated by PET-CT [ 10 ], breast MRI, ultrasonographic examination [ 11 ], and mammography [ 12 ] at approximately 4 months and approximately 10 months after KORTUC II, and these examinations were repeated biannually for at least 5 years after KORTUC II treatment, thereafter. Only one patient (case 5 in Table 1 , Table 2 and Table 3 ) had local recurrence, which was discovered at 39 months; this patient died after 83 months of KORTUC II.…”
Section: Resultsmentioning
confidence: 99%