Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders

Ray, Sujoy; Ray, Amita

doi:10.1002/14651858.cd010338.pub3

Cited by 14 publications

(6 citation statements)

References 69 publications

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“…Surgical treatments are recommended in the presence of medical therapy failure, severe anemia, or other concomitant uterine pathology [ 6 ]. However, tranexamic acid not only increases the risk of thrombosis but also has side effects such as headache, anemia, and fatigue [ 7 ]. In addition to the risks of blood loss and ureteric injury, hysterectomy is not suitable for the women with fertility plan.…”

Section: Introductionmentioning

confidence: 99%

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

Lin

Chiang

et al. 2017

BMC Complement Altern Med

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BackgroundMany patients with gynecological disorders seek traditional medicine consultations in Asian countries. This study intended to investigate the utilization of traditional Chinese medicine (TCM) in patients with dysfunctional uterine bleeding (DUB) in Taiwan.MethodsWe analyzed a cohort of one million individuals randomly selected from the National Health Insurance Research Database in Taiwan. We included 46,337 subjects with newly diagnosed DUB (ICD-9-CM codes 626.8) from January 1, 1997 to December 31, 2010. The patients were categorized into TCM seekers and non-TCM seekers according to their use of TCM.ResultsAmong the subjects, 41,558 (89.69%) were TCM seekers and 4,779 (10.31%) were non-TCM seekers. Patients who were younger tended to be TCM seekers. Most of the patients had also taken Western medicine, especially tranexamic acid and non-steroidal anti-inflammatory drugs (NSAIDs). More than half of TCM seekers (55.41%) received combined treatment with both Chinese herbal remedies and acupuncture. The most commonly used TCM formula and single herb were Jia-Wei-Xiao-Yao-San (Bupleurum and Peony Formula) and Yi-Mu-Cao (Herba Leonuri), respectively. The core pattern of Chinese herbal medicine for DUB patients consisted of Jia-Wei-Xiao-Yao-San, Xiang-Fu (Rhizoma Cyperi), and Yi-Mu-Cao (Herba Leonuri).ConclusionsTCM use is popular among patients with DUB in Taiwan. Further pharmacological investigations and clinical trials are required to validate the efficacy and safety of these items.

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Section: Introductionmentioning

confidence: 99%

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

Lin

Chiang

et al. 2017

BMC Complement Altern Med

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“…The care of girls and women with HMB and IBD is complex. Treatments are limited (hormonal therapy; antifibrinolytics and desmopressin or factor replacement in more severe cases) and we have little in the way of high quality, longitudinal data, or indeed clinical trial data, 35,41,42 which details how well patients respond to each of these therapies. Future efforts should focus on ensuring that menstrual health is evaluated at every routine clinician‐patient contact, during childbearing years, and that we also aim to collect high quality, prospective, patient reported outcomes for girls and women with IBD to direct future management as effectively as possible.…”

Section: Heavy Menstrual Bleeding: From Menarche To Menopausementioning

confidence: 99%

Women and girls with inherited bleeding disorders: Focus on haemophilia carriers and heavy menstrual bleeding

Hermans,

Johnsen,

Curry

2024

Haemophilia

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Raising awareness and improving recognition, accurate classification, and enhanced access to new treatments represent current key challenges for carriers of haemophilia. Women and girls carrying genes for haemophilia often experience significant bleeding and/or low factor levels. The bleeding associated with female haemophilia is frequently overlooked, has a weak correlation with factor levels, and manifests differently than in males, with heavy menstrual bleeding being a predominant symptom. Recent changes in terminology now allow the diagnosis of haemophilia in females with low factor levels and differentiate between symptomatic and asymptomatic carriers of the gene.Observations from real‐world experiences and limited clinical trial data have highlighted the positive impact of various new haemophilia treatments for women and girls with clotting factor deficiencies. There is an urgent need for initiatives that increase their access to these treatments and encourage well‐designed clinical trials focusing on female‐specific outcomes.In women with inherited bleeding disorders, early recognition and optimal management of heavy menstrual bleeding are crucial. However, treatment options and guidance from high‐quality clinical trials are currently insufficient. Menstrual health assessment should be a regular part of monitoring women and girls with inherited bleeding disorders throughout their lives, emphasizing the importance of gathering data to improve future management.

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“…Hormonal therapy is the other cornerstone of HMB management in women with IBDs 20,26 . Combined hormonal contraceptives (CHCs) provide an oestrogen (usually ethinyl estradiol), helpful in adolescents to obtain more regular and predictable cycles, and a progestin (a synthetic form of progesterone) which reduce menstrual blood loss by downregulating endometrial oestrogen receptors, thereby reducing glandular proliferation and inducing endometrial atrophy.…”

Section: Management Of Hmb In Women With Ibdsmentioning

confidence: 99%

Big picture initiatives in bleeding disorders

et al. 2022

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Introduction:The inherited bleeding disorders (IBD) community has witnessed significant therapeutic advances recently, yet important gaps persist, particularly for those with rare disorders and historically underserved populations. Aims:-To create a national research blueprint agenda, led by the National Hemophilia Foundation (NHF), enhancing patient-centric principles, accelerate research progress and address important gaps in care.-To review critical gaps that remain to be addressed in women with IBDs, who face specific bleeding challenges. Methods:The NHF research blueprint research agenda was defined by input from across the community, including caregivers and patients who are considered subject matter experts of their IBD, research leaders, allied health professionals and specialists, and representatives of the biopharmaceutical industry. In addition, two medical experts in the field of IBDs performed a comprehensive review to address the knowledge gaps in women with IBDs.Results: Two foundational principles of the NHF blueprint are: (1) it must deliver on key issues that significantly impact the lives of those affected by IBDs, and (2) the priorities defined are relevant and actionable aimed to achieve health equity among all those affected by IBDs. A multidisciplinary approach is necessary for an optimal management of puberty, transition to adulthood and pregnancy. Even if strict guidelines are followed, recent studies show that women with IBDs are still facing a high burden.Conclusion: NHF blueprint will be issued in 2022. A specific research agenda is needed in women with IBDs to further improve their management and quality of life.

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Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders

Abstract: Ray S, Ray A. Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders.

Cited by 14 publications

References 69 publications

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study

Women and girls with inherited bleeding disorders: Focus on haemophilia carriers and heavy menstrual bleeding

Big picture initiatives in bleeding disorders

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