Non surgical management of cystic lymphangioma

Rawat, Jiledar; Sinha, Shandip Kumar; Kanojia, Ravi Prakash; Wakhlu, Asish; Kureel, Shiv Narain; Tandon, Rajul

doi:10.1007/bf03049593

Cited by 16 publications

(24 citation statements)

References 15 publications

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“…Sites other than head and neck include axilla, mediastinum, thigh, chest and abdominal wall [5]. Landing and Ferber classified lymphatic malformationsinto 3 types (i) Lymphangioma simplex: consisting of thin lymphatic channels of capillary size, (ii) Cavernous lymphangioma: composed of dilated lymphatic channels, (iii) Cystic lymphangioma: consists of cysts having diameter of few millimeters to centimeters [6,7]. Combinationof these groups are frequently detected in the same lesion.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical resection is the traditional modality of management but is associated with high rate of complications and total excision is not possible in every case. The reported recurrence rate after resection of lymphangioma varies from 15 to 53% [7,8]. Therefore, nonsurgical methods such as sclerotherapy have emerged as alternative mode of management.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, nonsurgical methods such as sclerotherapy have emerged as alternative mode of management. Sclerosants act by destroying the epithelial lining of the cysts followed by collapse and scarring [7,9]. Sclerosing agents such as Ethanol and Sodium tetradecyl sulphate (STS) became popular initially and are commonly used [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…However, in the recent years OK-432 and Bleomycin are favoured by many surgeons due to encouraging results. But, OK-432 is not easily available and is costly [6,7]. Bleomycin was first discovered as a cytotoxic antitumor antibiotic and later on used as a sclerosing agent in lymphangiomas [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Intralesional bleomycin versus sodium tetradecyl sulphate in the management of peripheral lymphangiomas in children: a prospective comparative study

Nayak¹,

P.K.²,

Jena³

et al. 2017

Int J Pediatr Res

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Introduction: Surgical resection in lymphangiomas is associated with high rate of complications, recurrences and total excision is not possible in every case. Therefore, sclerotherapy have emerged as alternative mode of management. It is essential to know the efficacy of the sclerosants and the merits and demerits of the agents. However, a prospective study comparing the efficacies of the sclerosing agents exclusively on lymphangioma is lacking. Methods: A prospective, comparative clinical trial was conducted in a tertiary health care pediatric institute among lymphangioma patients. Patients were divided into two groups by randomisation; Group A: patients in whom intralesional bleomycin injection was administered, Group B: patients in whom intralesional sodium tetradecyl sulphatewas administered. Both the groups were compared with respect to clinical presentation, efficacy of the drugs and side effects/complications. Result: Out of 36 patients included in this study, 18 patients were treated with intralesional bleomycin and 18 patients with intralesional sodium tetradecyl sulphate. Most common site of lymphangioma was neck (44.5%) followed by axilla in 27.7% of cases. Reduction in size was noted in 15 (83.3%) patients in group A, 9 (50%) had excellent response, while 6 (33%) had good response. Reduction in size was noted in 12 (66%) patients in group B, 5 (27%) had excellent response while 7 (38%) had good response. Conclusion: Intralesional bleomycin and sodium tetradecyl sulphate are safe and effective sclerosing agents in peripheral lymphangiomas of children, but bleomycin is more effective in reducing the size of the lesions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intralesional bleomycin versus sodium tetradecyl sulphate in the management of peripheral lymphangiomas in children: a prospective comparative study

Nayak¹,

P.K.²,

Jena³

et al. 2017

Int J Pediatr Res

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“…12 However, the doses used in sclerotherapy were much smaller and authors in their series with intralesion albleomycin therapy reported nil pulmonary fibrosis as a complication. 13 Current study used 0.5 mg/kg of dose. Others have used it in doses ranging from 0.3 to 3 mg/kg.…”

mentioning

confidence: 99%

Ultrasound guided intralesional bleomycin therapy for cystic lymphangioma in childhood

Pan¹

2017

Int J Contemp Pediatr

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Background: Lymphangiomas are benign hamartomatous lymphatic tumors, characterized by multiple communicating lymphatic channels and cystic spaces. They occur in nearly all regions of the body but are most frequently seen in the neck (75%), axilla (20%), and inguinal areas (2%). This study aims to evaluate the effectiveness of intralesional bleomycin sclerotherapy in the treatment of cystic lymphangioma in children and to determine the incidence of complications in the treatment.Methods: This is a prospective study of 36 children diagnosed with cystic lymphangioma and treated with intralesional injection of bleomycin aqueous solution from 2008 to 2015.Results: Complete resolution was seen in (16/36) of lesions, (17/36) had a good response and (3/36) had a poor response. The tumour recurred in 3 patients. No other serious complications or side effects were observed.Conclusions: Intralesional bleomycin therapy was very effective in the treatment of cystic lymphangioma. Our results were comparable to other published studies. Bleomycin administered as intralesional injection was found to be safe as there was no serious complication or side effect observed in this study.

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