Non-surgical management of peripheral vascular disease: a review.

Clyne, C. A. C.

doi:10.1136/bmj.281.6243.794

Cited by 22 publications

(4 citation statements)

References 49 publications

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“…This latter has a success rate about the same as surgical sympathectomy but of course with a much reduced hospital stay and avoidance of quite a major operation (Milleret, Lavaud and Gravier, 1980). In spite of their increasing sales, there do not seem to be any satisfactory controlled clinical studies which confirm that vasodilator drugs increase the walking distance of the patient with claudication (Clyne, 1980).…”

Section: Arteriosclerotic Obstructionmentioning

confidence: 96%

Review of general surgery 1980

Ellis

1981

Postgraduate Medical Journal

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Section: Arteriosclerotic Obstructionmentioning

confidence: 96%

Review of general surgery 1980

Ellis

1981

Postgraduate Medical Journal

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“…They tend to deal with a variety of issues on a particular topic and are useful to consult if one wishes a broad perspective. They also perform an important role as authors can integrate two or more independent fields of research13–15. Narrative reviews, however, are rarely explicit about study selection, assessment or analysis, and so do not alert readers to the existence of potential bias16, 17.…”

Section: Types Of Reviewmentioning

confidence: 99%

Systematic reviews and meta-analysis for the surgeon scientist

Mahid

Hornung

Minor

et al. 2006

British Journal of Surgery

104

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Background: Understanding of data-reporting methods is imperative for correct interpretation of the medical literature as well as for proper performance of future clinical research. Recent developments in biostatistics have greatly changed the types of statistical analyses used and the minimum quality standards that must be maintained.Method: Different types of review are described, including systematic review with and without metaanalysis. Minimum reporting standards, sources of bias, both quantitative and qualitative, and references are discussed. Results and Conclusion: Meta-analysis has become a clearly defined technique, with reporting standards for both randomized controlled trials and observational studies. It is assuming a wider role in the surgical literature. Although many sources of bias exist, there are clear reporting standards and readers should be aware of these when studying the literature.

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“…Pathophysiologically, such changes might be brought about by reductions in tissue blood flow; reduced blood flow to skeletal muscle has been associated with the metabolic response to surgical trauma, which includes a depression of muscle protein synthesis (Lundholm et al, 1982;Rennie et al, 1984). Furthermore, muscle wasting is common in patients with peripheral vascular disease, with the degree of wasting said to be proportional to the severity of occlusion (Clyne, 1980), and we have preliminary evidence of a depression of muscle protein synthesis in such patients (MacLennan et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Effects of ischaemia, blood loss and reperfusion on rat muscle protein synthesis, metabolite concentrations and polyribosome profiles in vivo

Maclennan

Rennie

1989

Biochemical Journal

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In adult rat gastrocnemius muscles, on reperfusion after 45 min of tourniquet ischaemia, protein synthetic rates were depressed by over half for 1 h compared to normal (12%/day), and were at least one-third below normal for up to 5 h afterwards. Ischaemia caused muscle concentrations of phosphocreatine to be depressed by 70%, and those of lactate to be elevated by 350%; the proportion of ribosomes as polyribosomes was decreased by half. Unlike the rates of protein synthesis, all of these variables returned to normal after 35 min of reperfusion. When 25% of the blood volume was removed (for 10-45 min), there were falls in the rate of gastrocnemius protein synthesis and in phosphocreatine concentration, and an increase in lactate concentration. On blood replacement, protein synthesis and metabolite concentrations returned to normal within 15 min. Polyribosome profiles were unaffected by blood loss or replacement. There were highly significant correlations between the rate of gastrocnemius protein synthesis and both phosphocreatine concentration and 1/(lactate concentration), during blood loss and replacement, i.e. during both the fall and rise in muscle energy status. We conclude that the effects of ischaemia and blood loss on protein synthesis are not equivalent.

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Non-surgical management of peripheral vascular disease: a review.

Cited by 22 publications

References 49 publications

Review of general surgery 1980

Review of general surgery 1980

Systematic reviews and meta-analysis for the surgeon scientist

Effects of ischaemia, blood loss and reperfusion on rat muscle protein synthesis, metabolite concentrations and polyribosome profiles in vivo

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