Non‐Surgical Pocket Therapy: Pharmacotherapeutics

Drisko, Connie Hastings

doi:10.1902/annals.1996.1.1.491

Cited by 93 publications

(83 citation statements)

References 340 publications

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“…Other studies have assessed subgingival antimicrobial treatment without concomitant SRP as well as adjunctive to SRP. 10 Results of this trial compare favorably with these trials.…”

Section: Discussionmentioning

confidence: 77%

Two Multi‐Center Studies Evaluating Locally Delivered Doxycycline Hyclate, Placebo Control, Oral Hygiene, and Scaling and Root Planing in the Treatment of Periodontitis

Garrett¹,

Johnson

Drisko

et al. 1999

Journal of Periodontology

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149

131

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Results of this trial demonstrate that treatment of periodontitis with subgingivally delivered doxycycline in a biodegradable polymer is equally effective as scaling and root planing and superior in effect to placebo control and oral hygiene in reducing the clinical signs of adult periodontitis over a 9-month period. This represents positive changes resulting from the use of subgingivally applied doxycycline as scaling and root planing was not limited regarding time of the procedure or use of local anesthesia.

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“…Other studies have assessed subgingival antimicrobial treatment without concomitant SRP as well as adjunctive to SRP. 10 Results of this trial compare favorably with these trials.…”

Section: Discussionmentioning

confidence: 77%

Two Multi‐Center Studies Evaluating Locally Delivered Doxycycline Hyclate, Placebo Control, Oral Hygiene, and Scaling and Root Planing in the Treatment of Periodontitis

Garrett¹,

Johnson

Drisko

et al. 1999

Journal of Periodontology

Self Cite

149

131

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“…Putative pathogens associated with periodontal disease are susceptible to a variety of antiseptics and antibiotics [2,3]. Methods employed to convey antimicrobial agents into periodontal pockets include rinsing, irrigation, systemic administration and local application using sustained and controlled delivery devices.…”

Section: Original Articlementioning

confidence: 99%

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy

Panwar

Gupta²

2009

Medical Journal Armed Forces India

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Background: Scaling and root planing is the basic treatment modality for periodontal disease. Mechanical treatment is limited by physical impediments and biochemical considerations. Antimicrobial agents may be used as an adjunct to overcome limitations of mechanical therapy. Methods: A case-control study was carried out on 30 patients suffering from chronic periodontitis. In Group A only scaling and root planing was carried out whereas in Group B tetracycline fibers were used along with scaling and root planing. Result: Tetracycline fibers as an adjunct to scaling and root planing was found to be more effective in reducing inflammation. The number of sites with bleeding on probing were 12 in Group A as compared to four in Group B after 30 days. The mean decrease in probing depth was more in Group B than Group A after 30 and 90 days. General linear model showed that decrease in probing depth was statistically significant with both mechanical therapy as well as adjunctive use of tetracycline fibers. Conclusion: Local drug delivery with tetracycline fiber is an effective and simple non surgical method to improve periodontal health which can be practiced even by a general dental practitioner. MJAFI 2009; 65 : 244-246

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“…For the successful treatment of periodontitis, the microbial levels of the bacteria that are responsible for the periodontal infection within the oral cavity have to be minimized significantly [1,2]. Both local and systemic applications of antibiotics are effective in eliminating bacterial infections [3].…”

Section: Introductionmentioning

confidence: 99%

Systemic detection of doxycycline after local administration

Kim

Lee

Eickholz

et al. 2009

Acta Odontologica Scandinavica

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Systemic contamination with doxycycline after topical administration may occur even after unisite application if no periodontal dressing is used. Locally administered doxycycline can be identified in the systemic circulation at levels far below those expected to have antibacterial effects. Systemic concentration following application to a single site was always below levels capable of detection by HPLC.

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Non‐Surgical Pocket Therapy: Pharmacotherapeutics

Cited by 93 publications

References 340 publications

Two Multi‐Center Studies Evaluating Locally Delivered Doxycycline Hyclate, Placebo Control, Oral Hygiene, and Scaling and Root Planing in the Treatment of Periodontitis

Two Multi‐Center Studies Evaluating Locally Delivered Doxycycline Hyclate, Placebo Control, Oral Hygiene, and Scaling and Root Planing in the Treatment of Periodontitis

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy

Systemic detection of doxycycline after local administration

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