2021
DOI: 10.36740/wlek202103129
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Non-Surgical Treatment of Peyronie’s Disease: A Comprehensive Review

Abstract: This review article focuses on conservative treatment options, topical, intralesional therapy, traction and vacuum therapy. A PubMed database search was performed for studies that were published between 1948 and 2019. Search keywords included “Peyronie’s disease,” “conservative therapy,” “traction treatment,” “extracorporeal shock wave therapy,” “topical and oral therapies,” and “vaccum therapy.” Clinical trials in men with Peyronie’s disease and scientific articles relating to pharmacologic data were included… Show more

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Cited by 2 publications
(4 citation statements)
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“…There was no significant benefit demonstrated when assessing plaque size, pain or penile length. This is in keeping with another recent review which included observational studies as well [ 73 ]. Interestingly many observational “real world” post-approval studies [ 74 76 ] have shown intralesional CCH to be of benefit in acute phases of PD, but these findings are yet to be confirmed in RCTs.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…There was no significant benefit demonstrated when assessing plaque size, pain or penile length. This is in keeping with another recent review which included observational studies as well [ 73 ]. Interestingly many observational “real world” post-approval studies [ 74 76 ] have shown intralesional CCH to be of benefit in acute phases of PD, but these findings are yet to be confirmed in RCTs.…”
Section: Discussionsupporting
confidence: 88%
“…Although there is enormous interest in non-surgical treatment options of PD, there is still a paucity of data from large, well conducted randomised trials within the literature. Other reviews [ 73 , 80 , 81 ] of the literature have focused only on selected non-surgical treatments or have included studies other than randomised trials resulting in a varied and inconclusive evidence based which has at times conflicted with our findings. This systematic review provides the most up-to date and extensive summary of all non-surgical treatments for PD, including only high-quality randomised trials.…”
Section: Discussionmentioning
confidence: 80%
“…82 It is said that PTT enhances the functioning of collagenases and metalloproteinases. 83 In recent years, PTT has been used in PD patients regardless of the disease phase. 84 In a prospective, non-blinded trial, 55 patients undergoing PTT in the acute phase of PD were compared with 41 patients in a control group.…”
Section: Penile Traction Therapymentioning
confidence: 99%
“…PTT uses mechanical force to elongate the phallus and boost mechanotransduction, leading to the modification of the extracellular matrix, which impacts cell apoptosis and proliferation 82 . It is said that PTT enhances the functioning of collagenases and metalloproteinases 83 . In recent years, PTT has been used in PD patients regardless of the disease phase 84 …”
Section: Physical Therapymentioning
confidence: 99%