Non‐syndromic cleft lip with or without palate‐susceptible SNPs is associated with hyperdontia

Abstract

Background Non‐syndromic supernumerary teeth (NSST) or hyperdontia may share common genetic determinants with non‐syndromic cleft lip with or without palate (NSCL/P). The aim of this study was to test the associations between five genome‐wide‐associated NSCL/P‐susceptible single nucleotide polymorphisms (SNPs) (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) and the occurrence of NSST. Materials and methods A total of 163 cases and 326 controls were recruited and their genomic DNA was extracted from blood samples. Five NSCL/P‐susceptible SNPs (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) were genotyped by TaqMan method. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the associations between the SNPs and the risk of NSST by PLINK software. Results Rs4791774 (A > G) and rs13041247 (T > C) were associated with risk of NSST (rs4791774: Padd = 0.011, OR, 95% CI = 0.62, 0.43–0.90; rs13041247: Phomo = 0.031, OR, 95% CI = 1.79, 1.05–3.05) and one supernumerary tooth (rs4791774: Pdom = 0.009, OR, 95% CI = 0.56, 0.36–0.87; rs13041247: Phomo = 0.034, OR, 95% CI = 1.82, 1.05–3.15). Rs4791774 (A > G) was also showed association with risk of upper arch supernumerary teeth only (Padd = 0.010, OR, 95% CI = 0.60, 0.41–0.89). Conclusion Non‐syndromic cleft lip with or without palate‐susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth.

A rare case of an intra-nasal ectopic tooth leading to rhinolith

“…To solve symptoms and prevent further complications, surgically removing the tooth has been proposed as treatment. 15 When the tooth is inserted in the bone, the procedure becomes complex, but it still has important possible major complications, such as infection and hemorrhage, that indicate general anesthesia as a safer protocol to be followed. Finally, intranasal ectopic tooth is somehow rare but is potentially harmful when left untreated; thus, surgically removing the…”

Intranasal Ectopic Tooth in Adult and Pediatric Patients: A Report of Two Cases

“…Another hypothesis that could be taken into consideration is an ectopic eruption of a supernumerary tooth [1]. Theories have been developed to explain the formation of a supernumerary tooth [1], including theories involving single nucleotide polymorphisms [15] and dental lamina hyperactivity [1, 16]. Clinically, both patients had missing permanent tooth.…”