Results: 538 in total of related articles and abstracts were obtained from using the electronic search. During the initial screening, 420 articles were excluded. 118 articles were then completely evaluated resulting in only 53 being assesed as it fulfills the inclusion criteria of the systematic review. At the end, only 18 studies were used for assessment. Conclusion: In a nutshell, the capability of deciding on a treatment for patients that have hypodontia in accordance to the evidence is not yet possible. Although implant therapy for hypodontia patients have a better outcome, when dealing with children, removable partial denture is the most suitable choice.