Non-target-site herbicide resistance: a family business

Yuan, Joshua S.; Tranel, Patrick J.; Stewart, C. Neal

doi:10.1016/j.tplants.2006.11.001

Cited by 474 publications

(603 citation statements)

References 89 publications

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“…Cytochrome P450s are a large family of plant enzymes, some of which are capable of herbicide metabolism, at least in grass species (Powles and Yu, 2010). In plants there are many P450 genes evident (300 genes have been identified in the Arabidopsis genome) and chemical defense seems to be a major reason for plant P450 diversification (Yuan et al, 2007;Mizutani and Ohta, 2010). In this inheritance study the P450-based herbicide metabolism in one L. rigidum population is likely conferred by two genes.…”

Section: Discussionmentioning

confidence: 82%

Genetic control of a cytochrome P450 metabolism-based herbicide resistance mechanism in Lolium rigidum

2010

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The dynamics of herbicide resistance evolution in plants are influenced by many factors, especially the biochemical and genetic basis of resistance. Herbicide resistance can be endowed by enhanced rates of herbicide metabolism because of the activity of cytochrome P450 enzymes, although in weedy plants the genetic control of cytochrome P450-endowed herbicide resistance is poorly understood. In this study we have examined the genetic control of P450 metabolism-based herbicide resistance in a well-characterized Lolium rigidum biotype. The phenotypic resistance segregation in herbicide resistant and susceptible parents, F1, F2 and backcross (BC) families was analyzed as plant survival following treatment with the chemically unrelated herbicides diclofop-methyl or chlorsulfuron. Dominance and nuclear gene inheritance was observed in F1 families when treated at the recommended field doses of both herbicides.The segregation values of P450 herbicide resistance phenotypic traits observed in F2 and BC families was consistent with resistance endowed by two additive genes in most cases. In obligate out-crossing species such as L. rigidum, herbicide selection can easily result in accumulation of resistance genes within individuals.

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Section: Discussionmentioning

confidence: 82%

Genetic control of a cytochrome P450 metabolism-based herbicide resistance mechanism in Lolium rigidum

2010

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“…ABC transporters comprise a large family with more than 130 genes that have many roles in the cell, including: excretion of toxic compounds, sequestration of secondary metabolites, and translocation of lipids and phospholipids (Yuan et al, 2007). The transformed plant Arabidopsis thaliana overexpressing an ABC transporter gene has been shown to exhibit resistance to the herbicides pendimenthalin, dicamba and MSMA (Windsor et al, 2003).…”

Section: Reduction Of Absorption or Translocationmentioning

confidence: 99%

A Modified phosphate-carrier protein theory is proposed as a non-target site mechanism For glyphosate resistance in weeds

Roso

Vidal

2010

Planta daninha

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-Glyphosate is an herbicide that inhibits the enzyme 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSPs) (EC 2.5.1.19). EPSPs is the sixth enzyme of the shikimate pathway, by which plants synthesize the aromatic amino acids phenylalanine, tyrosine, and tryptophan and many compounds used in secondary metabolism pathways. About fifteen years ago it was hypothesized that it was unlikely weeds would evolve resistance to this herbicide because of the limited degree of glyphosate metabolism observed in plants, the low resistance level attained to EPSPs gene overexpression, and because of the lower fitness in plants with an altered EPSPs enzyme. However, today 20 weed species have been described with glyphosate resistant biotypes that are found in all five continents of the world and exploit several different resistant mechanisms. The survival and adaptation of these glyphosate resistant weeds are related toresistance mechanisms that occur in plants selected through the intense selection pressure from repeated and exclusive use of glyphosate as the only control measure. In this paper the physiological, biochemical, and genetic basis of glyphosate resistance mechanisms in weed species are reviewed and a novel and innovative theory that integrates all the mechanisms of non-target site glyphosate resistance in plants is presented.Keywords: membrane carrier proteins, herbicide, weed resistance.RESUMO -Glyphosate é uma glicina fosfonada e inibe a enzima 5-enolpiruvil-shikimato-3-fosfato sintase (EPSPS) (EC 2.5.1.19). EPSPS é a sexta enzima da rota do shikimato, na qual são sintetizados os compostos do metabolismo secundário e os aminoácidos aromáticos fenilalanina, tirosina e triptofano. Alguns autores hipotetizaram que seria improvável a evolução de plantas daninhas resistentes a este herbicida. As justificativas estariam relacionadas à limitada metabolização de glyphosate nas plantas, ao baixo nível de resistência obtido com a superexpressão do gene EPSPS e à alta penalidade de adaptação oriunda de mutações no gene EPSPS. Mas, atualmente estão descritas 18 espécies com biótipos resistentes distribuídas em 17 países. A sobrevivência e adaptação estão relacionadas aos mecanismos de resistência que ocorrem nas plantas daninhas selecionadas em função da intensa pressão de seleção do herbicida. Esta revisão objetiva apresentar e discutir evidências fisiológicas, bioquímicas e genéticas que fundamentam os principais mecanismos envolvidos na resistência ao herbicida glyphosate em plantas daninhas.Palavras-chave: herbicida, proteínas carregadoras de membrana, planta daninha.

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“…Likewise, species-specific differences in herbicide tolerance can also be explained by differences in GST activity and the capacity for herbicide detoxification by glutathionylation (Van Eerd et al 2003;Yuan, Tranel & Stewart 2007).…”

Section: Introductionmentioning

confidence: 99%

Safeners recruit multiple signalling pathways for the orchestrated induction of the cellular xenobiotic detoxification machinery in Arabidopsis

Behringer

Bartsch

Schaller

2011

Plant Cell & Environment

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Safeners enhance herbicide tolerance in crop plants but not in target weeds, thus improving herbicide selectivity. The safeners isoxadifen-ethyl and mefenpyr-diethyl protect cereal crops from sulfonyl urea herbicides in postemergence application. The two safeners were shown here to induce the cellular xenobiotic detoxification machinery in Arabidopsis thaliana when applied to leaves in a way mimicking field application. Gene expression profiling revealed the induction of 446 genes potentially involved in the detoxification process. Transgenic Arabidopsis plants expressing a reporter gene under control of a safenerresponsive maize promoter were used as a model system to study the safener signalling pathway. Reporter gene analysis in the tga2/3/5/6, sid2-2 and npr1 mutants as compared with the wild-type background showed that safener inducibility required TGA transcription factors and salicylic acid (SA) in a NON-EXPRESSOR of PR-1 (NPR1)-independent pathway converging on two as-1 promoter elements. For the majority of the safener-responsive Arabidopsis genes, a similar dependence on TGA transcription factors and/or SA was shown by gene expression profiling in wild-type plants as compared with the tga2/3/5/6 and sid2-2 mutants. Thirty-eight percent of the genes, however, were induced by safeners in a TGA/SA-independent manner. These genes are likely to be controlled by WRKY transcription factors and cognate W-boxes in their promoters.

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Non-target-site herbicide resistance: a family business

Cited by 474 publications

References 89 publications

Genetic control of a cytochrome P450 metabolism-based herbicide resistance mechanism in Lolium rigidum

Genetic control of a cytochrome P450 metabolism-based herbicide resistance mechanism in Lolium rigidum

A Modified phosphate-carrier protein theory is proposed as a non-target site mechanism For glyphosate resistance in weeds

Safeners recruit multiple signalling pathways for the orchestrated induction of the cellular xenobiotic detoxification machinery in Arabidopsis

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