Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: a Mendelian randomization study
Shuang Chen,
Zhaokai Zhou,
Zihan Zhou
et al.
Abstract:BackgroundPrimary ovarian insufficiency (POI) is a common clinical endocrine disorder with a high heterogeneity in both endocrine hormones and etiological phenotypes. However, the etiology of POI remains unclear. Herein, we unraveled the causality of genetically determined metabolites (GDMs) on POI through Mendelian randomization (MR) study with the overarching goal of disclosing underlying mechanisms.MethodsGenetic links with 486 metabolites were retrieved from GWAS data of 7824 European participants as expos… Show more
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