Non-targeted metallomics through synchrotron radiation X-ray fluorescence with machine learning for cancer screening using blood samples

He, Liu; Yao, Lu; Li, Chao; Xie, Hongxin; Zhao, Jiating; Wang, Yating; Wang, Liming; Wang, Xin; Wang, Wei; Chen, Dongliang; Gao, Yuxi; Li, Bai; Li, Yufeng

doi:10.1016/j.talanta.2022.123486

Cited by 11 publications

(5 citation statements)

References 36 publications

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“…The microscopic X-ray fluorescence (μ-XRF) analysis was performed at the beamline of 4W1B, BSRF, which runs 2.5GeV with a current of 250 mA. A polychromatic beam (pink beam) with the energy of 10–18 keV was used as the incident X-rays . The mapping was acquired by fly-scan mode using Mamba data acquisition software. , The mapping was performed with a beam size of 50 × 50 μm 2 .…”

Section: Methodsmentioning

confidence: 99%

Spatial Metallomics Reveals Preferable Accumulation of Methylated Selenium in a Single Seed of the HyperaccumulatorCardamine violifolia

Xie

Xue

et al. 2023

J. Agric. Food Chem.

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Cardamine violifolia is a Se hyperaccumulator found in Enshi, China. In this study, spatial metallomics was applied to visualize the distribution and speciation of Se in a single seed of C. violifolia. It was found that Se reached 1729.89 ± 28.14 mg/kg and the main Se species were SeCys and SeMet in bulk seeds. Further in situ study on a single seed found that the methylated Se species located mostly in the episperm. This is the first visualized evidence of the in situ distribution of methylated Se species in the seeds of C. violifolia. In all, spatial metallomics finds a preferable accumulation of methylated Se species in the seed coat, which deepens the understanding of the tolerance of Se by C. violifolia. The protocol applied in this study may also be used for the understanding of the tolerance of heavy metals/metalloids in other hyperaccumulators.

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Section: Methodsmentioning

confidence: 99%

Spatial Metallomics Reveals Preferable Accumulation of Methylated Selenium in a Single Seed of the HyperaccumulatorCardamine violifolia

Xie

Xue

et al. 2023

J. Agric. Food Chem.

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“…The use of SR-XRF spectrometry for biochemical research has received some interest in this review period. He et al 152 investigated the application of non-targeted metallomics for cancer screening in blood serum using SR-XRF spectrometry and machine learning. Samples from cancer patients ( n = 100) and controls ( n = 100) were qualitatively and rapidly analysed by SR-XRF spectrometry (5 s acquisition time) and the data was used to build machine learning algorithms.…”

Section: Applications: Clinical and Biological Materialsmentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2023

J. Anal. At. Spectrom.

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“…The mapping was performed with a beam size of 50 × 50 µm 2 . A four-element Hitachi Vortex ® -ME4 silicon drift detector coupled to a Quantum Detectors Xspress3 multi-channel analyzer system was used [42]. Spectral data were normalized by PyMCA [43] (Python multichannel analyzer) and then plotted by Origin 9.0 (OriginLab).…”

Section: The Distribution and Transformation Of W And Se In Rice Tissuesmentioning

confidence: 99%

Nano-WSe2 Is Absorbable and Transformable by Rice Plants

Xue

Xie

et al. 2022

Molecules

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As typical transition metal dichalcogenides (TMDC), tungsten selenide (WSe2) nanosheets (nano-WSe2) are widely used in various fields due to their layered structures and highly tunable electronic and magnetic properties, which results in the unwanted release of tungsten (W) and selenium (Se) into the environment. However, the environmental effects of nano-WSe2 in plants are still unclear. Herein, we evaluated the impacts and fate of nano-WSe2 and micro-WSe2 in rice plants (Oryza sativa L.). It was found that both nano-WSe2 and micro-WSe2 did not affect the germination of rice seeds up to 5000 mg/L but nano-WSe2 affected the growth of rice seedlings with shortened root lengths. The uptake and transportation of WSe2 was found to be size-dependent. Moreover, W in WSe2 was oxidized to tungstate while Se was transformed to selenocysteine, selenomethionine, SeIV and SeVI in the roots of rice when exposed to nano-WSe2, suggesting the transformation of nano-WSe2 in rice plants. The exposure to nano-WSe2 brought lipid peroxidative damage to rice seedlings. However, Se in nano-WSe2 did not contribute to the synthesis of glutathione peroxidase (GSH-Px) since the latter did not change when exposed to nano-WSe2. This is the first report on the impacts and fate of nano-WSe2 in rice plants, which has raised environmental safety concerns about the wide application of TMDCs, such as WSe2 nanosheets.

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Non-targeted metallomics through synchrotron radiation X-ray fluorescence with machine learning for cancer screening using blood samples

Cited by 11 publications

References 36 publications

Spatial Metallomics Reveals Preferable Accumulation of Methylated Selenium in a Single Seed of the HyperaccumulatorCardamine violifolia

Spatial Metallomics Reveals Preferable Accumulation of Methylated Selenium in a Single Seed of the HyperaccumulatorCardamine violifolia

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Nano-WSe2 Is Absorbable and Transformable by Rice Plants

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