Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications

Dalei, Ganeswar; Das, Subhraseema; Das, Smruti Prava

doi:10.1039/c8ra09161g

Cited by 22 publications

(5 citation statements)

References 44 publications

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“…The well-growth of cells for PEG 10k -5PEG 150 -8S is comparable to that of the control group, which intuitively demonstrates excellent cytocompatibility of the hydrogel. In addition, the hemolysis ratios of the precursor and the extract of the PEG 10k -5PEG 150 -8S hydrogel are 1.8% and 0.1%, respectively (Figure S22), much lower than the critical hemolysis ratio of 5% for the safe use of biomaterials . Overall, it can be concluded that our full PEG hydrogels exhibit an excellent biocompatibility, which possess a promising application prospect in biomedical fields.…”

Section: Results and Discussionmentioning

confidence: 87%

Full Poly(ethylene glycol) Hydrogels with High Ductility and Self-Recoverability

Cai

Zhang

et al. 2020

ACS Appl. Mater. Interfaces

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Energy dissipation is a common mechanism to improve the ductility of polymeric hydrogels. However, for poly(ethylene glycol) (PEG) hydrogels, it is not easy to dissipate energy, as polymer chains are dispersed in water without strong interchain interactions or decent entanglement. The brittleness limits the real applications of PEG hydrogels, although they are promising candidates in biomedical fields, as PEG has been approved by the U.S. Food and Drug Administration. Herein, we chemically introduced a center for energy dissipation in the PEG hydrogel system. Amphiphilic segmented PEG derivatives were designed through the melt polycondensation of triethylene glycol (PEG150) and high molecular weight PEG in the presence of succinic acid and mercaptosuccinic acid as dicarboxylic acids. Full PEG hydrogels with elastic nanospheres as giant cross-linkers were facilely prepared by the self-assembly of esterified PEG150 segments and the oxidation of mercapto groups. The resultant full PEG hydrogels can dissipate energy by the deformation of elastic nanospheres with outstanding ductility and self-recoverability while maintaining the excellent biocompatibility owing to their full PEG components. This work provides an original strategy to fabricate full PEG hydrogels with high ductility and self-recoverability, potentially applicable in biomedical fields.

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Section: Results and Discussionmentioning

confidence: 87%

Full Poly(ethylene glycol) Hydrogels with High Ductility and Self-Recoverability

Cai

Zhang

et al. 2020

ACS Appl. Mater. Interfaces

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“…This behavior was also reported for Na5 1 * hydrogels and it can be related to the difference in osmotic pressure between the hydrogel’s structure and the saline solutions [ 24 ]. Furthermore, the neutral pH of the PBS solution (7.4) might induce an increase in the swelling ratio of hydrogels due to the deprotonation of -NH 3 and the intra-chain hydrogen bonds in the hydrogel matrix [ 42 ]. Nonetheless, the slight difference between the swelling ratio in PBS and NaCl 0.9% suggested the absence of a pH-sensitive swelling behavior.…”

Section: Resultsmentioning

confidence: 99%

Chitin-Glucan Complex Hydrogels: Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cells

et al. 2023

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Chitin-glucan complex (CGC) hydrogels were fabricated by coagulation of the biopolymer from an aqueous alkaline solution, and their morphology, swelling behavior, mechanical, rheological, and biological properties were studied. In addition, their in vitro drug loading/release ability and permeation through mimic-skin artificial membranes (Strat-M) were assessed. The CGC hydrogels prepared from 4 and 6 wt% CGC suspensions (Na51*4 and Na51*6 hydrogels, respectively) had polymer contents of 2.40 ± 0.15 and 3.09 ± 0.22 wt%, respectively, and displayed a highly porous microstructure, characterized by compressive moduli of 39.36 and 47.30 kPa and storage moduli of 523.20 and 7012.25 Pa, respectively. Both hydrogels had a spontaneous and almost immediate swelling in aqueous media, and a high-water retention capacity (>80%), after 30 min incubation at 37 °C. Nevertheless, the Na51*4 hydrogels had higher fatigue resistance and slightly higher-water retention capacity. These hydrogels were loaded with caffeine, ibuprofen, diclofenac, or salicylic acid, reaching entrapment efficiency values ranging between 13.11 ± 0.49% for caffeine, and 15.15 ± 1.54% for salicylic acid. Similar release profiles in PBS were observed for all tested APIs, comprising an initial fast release followed by a steady slower release. In vitro permeation experiments through Strat-M membranes using Franz diffusion cells showed considerably higher permeation fluxes for caffeine (33.09 µg/cm2/h) and salicylic acid (19.53 µg/cm2/h), compared to ibuprofen sodium and diclofenac sodium (4.26 and 0.44 µg/cm2/h, respectively). Analysis in normal human dermal fibroblasts revealed that CGC hydrogels have no major effects on the viability, migration ability, and morphology of the cells. Given their demonstrated features, CGC hydrogels are very promising structures, displaying tunable physical properties, which support their future development into novel transdermal drug delivery platforms.

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“…These differences between GG beads and CMGG beads, in terms of porosities and ceramic distribution in the organic part, are explained by the results of a study published by Dalei et al [ 15 ], where GG micrographs revealed a discrete and elongated structure with particles separated from each other, while CMGG micrographs showed a substantially altered morphology, with particles adhering to each other and forming larger aggregates, more evidence of an increased CMGG concentration.…”

Section: Resultsmentioning

confidence: 99%

“…Due to its glycopolysaccharide structure, GG, isolated from ground endosperm of Cyamopsis tetragonolobus or Cyamopsis psoraloides, interacts and binds with proteins in a physiological environment [ 13 ]. Carboxymethyl GG (CMGG) expresses increased hydrophilicity and clarity solution [ 14 ] and can be designed as nanoparticles and microspheres to hydrogels for various biomedical applications [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

et al. 2023

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The tendency of population aging is continuously increasing, which is directly correlated with a significative number of associated pathologies. Several metabolic bone diseases such as osteoporosis or chronic kidney disease–mineral and bone disorders involve a high risk of fractures. Due to the specific fragility, bones will not self-heal and supportive treatments are necessary. Implantable bone substitutes, a component of bone tissue engineering (BTE) strategy, proved to be an efficient solution for this issue. The aim of this study was to develop composites beads (CBs) with application in the complex field of BTE, by assembling the features of both biomaterials’ classes: biopolymers (more specific, polysaccharides: alginate and two different concentrations of guar gum/carboxymethyl guar gum) and ceramics (more specific, calcium phosphates), in a combination described for the first time in the literature. The CBs prepared by double crosslinking (ionic and physically) showed adequate physico-chemical characteristics and capabilities (morphology, chemical structure and composition, mechanical strength, and in vitro behaviour in four different acellular simulated body fluids) for bone tissue repair. Moreover, preliminary in vitro studies on cell cultures highlighted that the CBs were free of cytotoxicity and did not affect the morphology and density of cells. The results indicated that the beads based on a higher concentration of guar gum have superior properties than those with carboxymetilated guar, especially in terms of mechanical properties and behaviour in simulated body fluids.

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Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications

Abstract: Surface nano-textured carboxymethyl guar gum/chitosan smart hydrogels by non-thermal plasma for biomedical applications.

Cited by 22 publications

References 44 publications

Full Poly(ethylene glycol) Hydrogels with High Ductility and Self-Recoverability

Full Poly(ethylene glycol) Hydrogels with High Ductility and Self-Recoverability

Chitin-Glucan Complex Hydrogels: Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cells

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

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