Non-thermal plasma wound healing after removal of a neck tumor in a patient with HIV: A case report

Peña‐Eguiluz, R.; López-Callejas, Régulo; González-Arciniega, Erasmo; Rodríguez-Méndez, B G; Mercado-Cabrera, A.; Guakil-Haber, Alberto; García, Anuar Kuri; Mancilla, Angélica Eloisa Espinosa; Valencia-Alvarado, R.

doi:10.1016/j.xocr.2021.100391

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The electrical properties resemble those of curved-type reactors, such as plasma jets [28,29], or the Thorns plasma reactor [30]. In our previous work, we designed and constructed a reactor with a straight output, which has found applications in clinical settings for treating patients with burns [38], addressing oral health issues [49][50][51][52], managing diabetic foot conditions [53,54], and performing neck surgeries [55].…”

Section: Discussionmentioning

confidence: 99%

Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection

Arguello-Sánchez,

López-Callejas,

Rodríguez-Méndez

et al. 2023

Materials

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Non-thermal plasmas (NTPs), known as cold atmospheric plasmas (CAPs), hold great potential for diverse medical applications, including dentistry. However, traditional linear and rigid dielectric barrier discharge reactors used for NTP generation encounter limitations in accessing oral cavities and root canals. To address this issue, we have developed an innovative NTP reactor featuring an angled end for improved accessibility. The central copper electrode, with a 0.59 mm diameter and adjustable length for desired angulation, is coated with zircon powder (ZrSiO4) to ensure stable NTP generation. This central electrode is housed within a stainless steel tube (3 mm internal diameter, 8 mm external diameter, and 100 mm length) with a 27° angle at one end, making it ergonomically suitable for oral applications. NTP generation involves polarizing the reactor electrodes with 13.56 MHz radio frequency signals, using helium gas as a working medium. We introduce plasma-treated water (PTW) as an adjunctive therapy to enhance biofilm eradication within root canals. A synergistic approach combining NTP and PTW is employed and compared to the gold standard (sodium hypochlorite, NaOCl), effectively neutralizing Enterococcus faecalis bacteria, even in scenarios involving biofilms. Moreover, applying NTP in both gaseous and liquid environments successfully achieves bacterial inactivation at varying treatment durations, demonstrating the device’s suitability for medical use in treating root canal biofilms. The proposed NTP reactor, characterized by its innovative design, offers a practical and specific approach to plasma treatment in dental applications. It holds promise in combatting bacterial infections in root canals and oral cavities.

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Section: Discussionmentioning

confidence: 99%

Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection

Arguello-Sánchez,

López-Callejas,

Rodríguez-Méndez

et al. 2023

Materials

Self Cite

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“…Notably, this field of research is growing rapidly. Over the past few decades, “plasma medicine” has been employed for its anticancer properties [ 143 , 144 , 145 , 146 , 147 ], which have also shown to be successful in clinical studies [ 149 , 209 , 210 , 211 , 212 ]. These outcomes are focused on the anticancer activity of nonthermal plasma, providing new potential methods for curing serious cancers without affecting normal and healthy tissues in the future.…”

Section: Discussionmentioning

confidence: 99%

Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

Mumtaz

Rana

Choi

et al. 2022

IJMS

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Modern humanity wades daily through various radiations, resulting in frequent exposure and causing potentially important biological effects. Among them, the brain is the organ most sensitive to electromagnetic radiation (EMR) exposure. Despite numerous correlated studies, critical unknowns surround the different parameters used, including operational frequency, power density (i.e., energy dose), and irradiation time that could permit reproducibility and comparability between analyses. Furthermore, the interactions of EMR with biological systems and its precise mechanisms remain poorly characterized. In this review, recent approaches examining the effects of microwave radiations on the brain, specifically learning and memory capabilities, as well as the mechanisms of brain dysfunction with exposure as reported in the literature, are analyzed and interpreted to provide prospective views for future research directed at this important and novel medical technology for developing preventive and therapeutic strategies on brain degeneration caused by microwave radiation. Additionally, the interactions of microwaves with biological systems and possible mechanisms are presented in this review. Treatment with natural products and safe techniques to reduce harm to organs have become essential components of daily life, and some promising techniques to treat cancers and their radioprotective effects are summarized as well. This review can serve as a platform for researchers to understand the mechanism and interactions of microwave radiation with biological systems, the present scenario, and prospects for future studies on the effect of microwaves on the brain.

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“…Patients infected with the HIV virus are particularly vulnerable to the occurrence of hard-to-heal wounds. Eguiluz et al [ 54 ] described the case of an infected patient who was diagnosed with a tumor in the neck area. The tumor was removed and NTP therapy was applied as a coadjutant of wound closure.…”

Section: Plasma Antiseptic Propertiesmentioning

confidence: 99%

Non-Thermal Plasma Application in Medicine—Focus on Reactive Species Involvement

Moszczyńska

Roszek

Wiśniewski

2023

IJMS

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Non-thermal plasma (NTP) application in medicine is a dynamically developing interdisciplinary field. Despite the fact that basics of the plasma phenomenon have been known since the 19th century, growing scientific attention has been paid in recent years to the use of plasma in medicine. Three most important plasma-based effects are pivotal for medical applications: (i) inactivation of a broad spectrum of microorganisms, (ii) stimulation of cell proliferation and angiogenesis with lower plasma treatment intensity, and (iii) inactivation of cells by initialization of cell death with higher plasma intensity. In this review, we explain the underlying chemical processes and reactive species involvement during NTP in human (or animal) tissues, as well as in bacteria inactivation, which leads to sterilization and indirectly supports wound healing. In addition, plasma-mediated modifications of medical surfaces, such as surgical instruments or implants, are described. This review focuses on the existing knowledge on NTP-based in vitro and in vivo studies and highlights potential opportunities for the development of novel therapeutic methods. A full understanding of the NTP mechanisms of action is urgently needed for the further development of modern plasma-based medicine.

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Non-thermal plasma wound healing after removal of a neck tumor in a patient with HIV: A case report

Cited by 5 publications

References 30 publications

Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection

Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection

Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

Non-Thermal Plasma Application in Medicine—Focus on Reactive Species Involvement

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