Non-Thyroidal Illness Syndrome in Prognosis of Acute Ischemic Stroke

Abstract

Purpose: To investigate Non-Thyroidal Illness Syndrome (NTIS) and the association with National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) and functional improvement at 3 months in patients with acute ischemic stroke (AIS). Materials and methods: we conducted a longitudinal observational study of 57 patients with AIS in Department of Endocrinology-Neurology of Hue Central Hospital from May 2018 to June 2019. Results: NTIS presenting with low FT3 and normal FT4, TSH accounted for 17.54% patients with AIS. NIHSS in the group with NTIS and without NTIS were 12 (8.75 - 15.75;CI: 95%) and 6 (4.00 - 8.00;CI: 95%), respectively. mRS on admission and at 3 months in the group with NTIS are 1.21 and 2.41 higher than in those without NTIS. mRS on admission was an independent prognostic factor of mRS at 3 months. With the cut-off FT3 > 3.755, it predicts patients are likely to recover with 63.90% sensitivity and 71.40% specificity with the Area Under the Cure of 0.70 (95%CI: 0.55 – 0.85). Conclusion: 17.54% patients with AIS had NTIS. The severity of stroke on admission with NIHSS and 3-months functional recovery with mRS in patients with NTIS are worse than in those without NTIS. Keywords: Non-thyroidal Illness Syndrome, Thyroid function test, acute ischemic stroke prognosis.