Non-traditional treatments for endometritis in mares

Abstract

SummaryBuczkowska, J., R. Kozdrowski, M. Sikora, M. Dzięcioł & A. Matusz, 2015. Non-traditional treatments for endometritis in mares. Bulg. J. Vet. Med., 18, No. 4,[285][286][287][288][289][290][291][292][293] Routine treatment for persistent mating-induced endometritis is directed at enhancing the clearance of accumulated fluid from the uterus and includes the use of ecbolic agents (oxytocin, prostaglandin F 2a ) which may be used alone or in combination with large-volume uterine lavage and administering antimicrobials if infection is diagnosed. However, traditional therapies are not always effective in resolving chronic uterine inflammation or infections. Treatment failure may be caused by uterine exudates, inspissated mucus or biofilm produced by some bacteria and yeast. Exudate can interfere with antibiotic penetration, whereas biofilm can confer antibiotic resistance. The endometrium of mares with delayed uterine clearance or chronic endometritis produces more mucus than reproductively healthy mares. Loss of cilia and abnormal mucus blanket provide areas for bacterial attachment. This review describes new strategies of endometritis treatment that may be added to typical therapy and includes intrauterine mucolytics, chelators, immunomodulators, corticosteroids, nonsteroidal antiinflammatory drugs and others.

Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana

“…Las vías de administración, las dosis y el agente bacteriano entre otros factores influyen en la elección del protocolo antibiótico para el tratamiento de la endometritis en yeguas (7). Por lo tanto, el objetivo del presente estudio fue evaluar la eficacia clínica de tres protocolos antibióticos en yeguas con diagnóstico de endometritis bacteriana y verificar su desempeño reproductivo postratamiento.…”

Efficacy of Intrauterine Hydrogen Peroxide and Povidone Iodine Administration to Treat Endometritic Mares

“…More commonly, antibiotics are used in mares (Ferris, 2017) to treat reproductive tract infections but with variable success rate. Treatment failure may be because of presence of uterine exudates, mucus or biofilm produced by some bacteria and yeast (Buczkowska et al, 2015).…”

Desafios diagnósticos e terapêuticos da endometrite em éguas: estudos experimentais e meta-análise

“…The presence of a mixed population of organisms, focal infections, highly pathogenic and biofilmproducing bacteria can also contribute to chronic inflammation and hinder findings during diagnostic exams such as microbiological culture and, consequently, antibiotic treatments. 13,27 Metagenomic studies revealed that a moderately diverse microbiome is also present in uterine samples, where no significant growth was obtained by conventional culture. 28 In addition, inadequate treatments and inefficient defense mechanisms leading to susceptibility can cause dysbiosis.…”