Non-traumatic Coma: Causes and Outcome of Adult Patients at University of Gondar Hospital, Northwest Ethiopia

Mohamed, Mohamed Abdulkadir; Bekele, Nebiyu; Diro, Ermias; Greffie, Ermias Shenkutie; Landers, Timothy; Shibiru, Habtewold; Gebremedhin, Helen; Muhammed, Murad; Abdu, Omer; Yesuf, Tesfaye

doi:10.11648/j.cmr.20150406.16

Cited by 5 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is associated with a poor prognosis in SSA, with reported in hospital case fatality rates ranging from 26–76% typically reflecting the seriousness of the underlying cause. 5 , 55 – 57 .…”

Section: Discussionmentioning

confidence: 99%

Neurological disorders in Northern Tanzania: A 6-year prospective hospital-based case series

Howlett¹,

Urasa²,

Maro³

et al. 2022

Afr H. Sci.

View full text Add to dashboard Cite

Background:The burden of neurological disorders is large and altered by the HIV epidemic. Objectives: We describe the pattern of neurological disorders and their association with HIV infection in adult patients attending a consultant hospital in Northern Tanzania. Methods: In this prospective cross-sectional study, we collected data on adult neurological referrals over a 6-year period between 2007-13. The odds of HIV infection, across neurological categories adjusted for age and sex, was calculated. Results: Of 2037 participants, 54.8% were male and 45.2% were female. The median age of participants was 43 years. The results for HIV screening were available for 992/2037 (48.7%) patients, of whom 306 (30.8%) were seropositive. The most frequent neurological disorders were cerebrovascular disease (19.9%), paraplegia (13.6%), and peripheral neuropathies (8%). Taken together CNS infection accounted for 278/2037 (13.6%). The adjusted odds (aOR) of HIV infection was highest amongst infections; brain abscesses (aOR 107, 95% CI 35.1-470.4) and meningitis/encephalitis (aOR 40.1, 95% CI 13.6-172.9), but also raised in cerebrovascular disease, paraplegia, peripheral neuropathies, cranial nerve palsies, seizures, cerebllar disorders, movement disorders, motor neuron disease andheadache. Conclusion: The main pattern of neurological disorders in Northern Tanzania is presented. The odds of HIV infection was highest in CNS infections and in a wide range of non-communicable neurological disorders. Keywords: Tanzania; neurological; disorder; neurological disease; hospital; HIV

show abstract

Section: Discussionmentioning

confidence: 99%

Neurological disorders in Northern Tanzania: A 6-year prospective hospital-based case series

Howlett¹,

Urasa²,

Maro³

et al. 2022

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

“…Non-traumatic comas, the most frequent, are dominated in Africa by infectious pathology. These include malaria and neuromeningeal infections, especially infectious meningitis [2][3][4][5][6][7][8][9][10]. The incidence of non-traumatic comas in chil-dren worldwide is 30 per 100,000 children [11][12].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

JPNB

View full text Add to dashboard Cite

IntroductionNon-traumatic coma is the most common pediatric medical emergency. Their therapeutic and evolutionary profile remains controversial in resource-limited countries. We report our experience with 370 children. ObjectiveTo evaluate the management and evolution of nontraumatic comas in the intensive care unit of the Pediatric Hospital Complex of Bangui (CHUPB). Materials and methods: This was a descriptive and analytical cross-sectional study conducted between January 1 and June 31, 2021 at the CHUPB. Children aged 1 month to 15 years, admitted to the intensive care unit of CHUPB with a Glasgow score less than or equal to 8 in a trauma-free setting were included. Data were entered and analyzed using SPSS 20.0 statistical software. The statistical test used was Pearson's chi-square. Any p-value <0.05 was considered statistically significant. ResultDuring the study period, 370 children were admitted to the intensive care unit of CHUPB for non-traumatic coma. The sex ratio was 1.35 and the mean age was 35.95±27.21 months. Neuromalaria (29.72%), meningitis-meningoencephalitis-encephalitis (30%), septic states (19.72%) and acidotic coma (5.40%) were the main etiologies. The children had received emergency drug treatment based on anticonvulsants in 59.18% of cases, antipyretics in 91.35% of cases and dopamine 18.1% of cases. Drug treatment was adapted to the etiology in 44.60% of cases and probabilistic in 55.40% (n=205) of cases. Neurological sequelae were noted in 8.93% of cases and death in 36.48%, 57.77% of which occurred within the first 48 hours. ConclusionInfectious diseases are the predominant cause of biologically documented non-traumatic comas and are also the cause of non-documented clinical situations. This reality has induced the use of anti-infectives beyond the rational with an outcome marked by high mortality and sequelae. The transformation of these outcomes requires the reinforcement of the technical platform of the CHUPB.

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic and Evolutionary Aspects of Non-Traumatic Comas in Central African Children

2022

JPNB

View full text Add to dashboard Cite

Introduction Non-traumatic coma is the most common pediatric medical emergency. Their therapeutic and evolutionary profile remains controversial in resource-limited countries. We report our experience with 370 children. Objective To evaluate the management and evolution of nontraumatic comas in the intensive care unit of the Pediatric Hospital Complex of Bangui (CHUPB). Materials and methods: This was a descriptive and analytical cross-sectional study conducted between January 1 and June 31, 2021 at the CHUPB. Children aged 1 month to 15 years, admitted to the intensive care unit of CHUPB with a Glasgow score less than or equal to 8 in a trauma-free setting were included. Data were entered and analyzed using SPSS 20.0 statistical software. The statistical test used was Pearson’s chi-square. Any p-value <0.05 was considered statistically significant. Result During the study period, 370 children were admitted to the intensive care unit of CHUPB for non-traumatic coma. The sex ratio was 1.35 and the mean age was 35.95±27.21 months. Neuromalaria (29.72%), meningitis-meningoencephalitis-encephalitis (30%), septic states (19.72%) and acidotic coma (5.40%) were the main etiologies. The children had received emergency drug treatment based on anticonvulsants in 59.18% of cases, antipyretics in 91.35% of cases and dopamine 18.1% of cases. Drug treatment was adapted to the etiology in 44.60% of cases and probabilistic in 55.40% (n=205) of cases. Neurological sequelae were noted in 8.93% of cases and death in 36.48%, 57.77% of which occurred within the first 48 hours. Conclusion Infectious diseases are the predominant cause of biologically documented non-traumatic comas and are also the cause of non-documented clinical situations. This reality has induced the use of anti-infectives beyond the rational with an outcome marked by high mortality and sequelae. The transformation of these outcomes requires the reinforcement of the technical platform of the CHUPB.

show abstract

Non-traumatic Coma: Causes and Outcome of Adult Patients at University of Gondar Hospital, Northwest Ethiopia

Cited by 5 publications

References 8 publications

Neurological disorders in Northern Tanzania: A 6-year prospective hospital-based case series

Neurological disorders in Northern Tanzania: A 6-year prospective hospital-based case series

Untitled

Therapeutic and Evolutionary Aspects of Non-Traumatic Comas in Central African Children

Contact Info

Product

Resources

About