Non-traumatic forensic neuropathology

Stewart, William; Black, Marjorie; Kalimo, Hannu; Graham, David I.

doi:10.1016/j.forsciint.2004.06.025

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…Si la isquemia es mantenida, provoca el infarto de una región específica de tejido del sistema nervioso central en el territorio de distribución del vaso comprometido [5]. Puede afectar por completo al territorio de la arteria afectada, pero si existe circulación colateral en los territorios arteriales adyacentes, el infarto puede estar restringido a la porción central del territorio arterial (Figura 4) [6]. Una enfermedad vascular oclusiva de intensidad suficiente para producir un infarto cerebral puede deberse, bien a una trombosis in situ o bien a una embolia procedente de un foco distante [5].…”

Section: Discussionunclassified

Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco

et al. 2008

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2 Médico Forense en prácticas. RESUMENLas enfermedades cerebrovasculares son consecuencia de una alteración en la circulación cerebral. Su forma más distintiva de presentación es el ictus, entendido como un déficit neurológico focal de instauración brusca y evolución rápida.Un infarto cerebral de origen oclusivo puede deberse bien a una trombosis in situ o bien a una embolia procedente de un foco distante. En las embolias cerebrales la causa principal son los trombos murales cardiacos y el área encefálica afectada con mayor frecuencia es el territorio irrigado por la arteria cerebral media.Presentamos el caso de una mujer de 81 años, con antecedentes de Hepatitis C, cardiopatía hipertensiva y fibrilación auricular crónica, que sufrió una fractura de cadera consecutiva a una caída accidental. Durante el ingreso hospitalario comenzó un cuadro de deterioro neurológico progresivo que no llegó a ser filiado, falleciendo 9 días después. En la autopsia médico-forense se encontró un infarto cerebral hemorrágico en el territorio de la arteria cerebral media izquierda. Dado que las arterias del Polígono de Willis eran permeables y ante la presencia de trombos vitales adheridos a la pared del ventrí-culo derecho, se estimó como causa más probable del accidente vasculocerebral la embolización de uno de dichos trombos.Palabras clave: enfermedad cerebrovascular, infarto cerebral hemorrágico, fibrilación auricular, trombo mural, patología forense. Forense 2008; 14(52):147-153 ABSTRACT Cerebrovascular diseases are due to a disturbance in cerebral blood flow. The most frequent way of presentation is stroke, defined as a sudden and focal neurological impairment with rapid evolution. Cuad MedCerebral infarction of occlusive origin can be secondary to in situ thrombosis or to embolism from a distal focus. Mural thrombi are the main cause of brain embolism and the middle cerebral artery territory is the most likely affected brain area.We report the case of an 81 year-old woman, with antecedents of Hepatitis C, hypertensive cardiopathy and chronic atrial fibrillation, who suffered a hip fracture due to an accidental fall. A progressive neurological impairment of unknown aetiology appeared during her hospitalization, and she died 9 days after her admission. Forensic autopsy found a hemorrhagic cerebral infarction in the territory of the left middle cerebral artery. As the arteries of the polygon of Willis were patent and there were vital thrombi adhered to the free wall of the right ventricle, thromboembolism was considered the most probable cause of the cerebrovascular event. INTRODUCCIÓN:Las enfermedades cerebrovasculares son consecuencia de una alteración en la circulación cerebral que ocasiona un déficit transitorio o definitivo del funcionamiento de una o varias partes del encéfalo, bien sea por un mecanismo isquémico o hemorrágico.Una enfermedad vascular oclusiva de intensidad suficiente para producir un infarto cerebral puede deberse, bien a una trombosis in situ o bien a una embolia procedente de un foco distante. En las e...

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Section: Discussionunclassified

Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco

et al. 2008

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“…This is crucial because the occurrence of epilepsy in infected individuals significantly affects the forensic evaluation of their injuries. Firstly, epilepsy itself is a critical assessment parameter in injury evaluation (Stewart et al, 2004). In Chinese law, according to current Chinese law, labor capacity assessment is divided into ten levels.…”

Section: Introductionmentioning

confidence: 99%

A novel deep learning model for glioma epilepsy associated with the identification of human cytomegalovirus infection injuries based on head MR

Wang,

Li,

et al. 2023

Front. Microbiol.

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PurposeIn this study, a deep learning model was established based on head MRI to predict a crucial evaluation parameter in the assessment of injuries resulting from human cytomegalovirus infection: the occurrence of glioma-related epilepsy. The relationship between glioma and epilepsy was investigated, which serves as a significant indicator of labor force impairment.MethodsThis study enrolled 142 glioma patients, including 127 from Shengjing Hospital of China Medical University, and 15 from the Second Affiliated Hospital of Dalian Medical University. T1 and T2 sequence images of patients’ head MRIs were utilized to predict the occurrence of glioma-associated epilepsy. To validate the model’s performance, the results of machine learning and deep learning models were compared. The machine learning model employed manually annotated texture features from tumor regions for modeling. On the other hand, the deep learning model utilized fused data consisting of tumor-containing T1 and T2 sequence images for modeling.ResultsThe neural network based on MobileNet_v3 performed the best, achieving an accuracy of 86.96% on the validation set and 75.89% on the test set. The performance of this neural network model significantly surpassed all the machine learning models, both on the validation and test sets.ConclusionIn this study, we have developed a neural network utilizing head MRI, which can predict the likelihood of glioma-associated epilepsy in untreated glioma patients based on T1 and T2 sequence images. This advancement provides forensic support for the assessment of injuries related to human cytomegalovirus infection.

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“…The practicing forensic pathologist is likely to encounter cases where either the cause of death or a major contribution to the cause of death is underlying damage to or disease of the central nervous system (CNS). 2 Hence, one should be well versed with the routine neuropathological conditions encountered in day-to-day practice.…”

Section: Introductionmentioning

confidence: 99%

Sudden neuropathological deaths: An autopsy study

et al. 2014

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A total of 7520 reported deaths were investigated. These included 291 sudden natural deaths, amongst which the death was attributed to neuropathology in 43 cases (14.7%). Of these 43 cases, 69.7% were male and 30.3% were female. The majority of cases (25.5%) were in those aged ≥60 years. Causes of neuropathology were due to subarachnoid haemorrhage in 48.8% of cases, stroke in 30.2%, meningitis in 14% and tumours in 7%. There was history of hypertension in 46.5% of cases, diabetes in 32.5% of cases and cardiac disease in 18.6% of cases.

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Non-traumatic forensic neuropathology

Cited by 9 publications

References 41 publications

Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco

Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco

A novel deep learning model for glioma epilepsy associated with the identification of human cytomegalovirus infection injuries based on head MR

Sudden neuropathological deaths: An autopsy study

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