Non-tuberculous<i>mycobacterial</i>bloodstream infections in patients with indwelling vascular catheters – the role of sickle cell anaemia

Edun, Babatunde; Shah, Ansal; Durkin, Martin; Whitmire, Melanie; Williams, Shanetta Patterson; Albrecht, Helmut; Al-Hasan, Majdi N.; Weissman, Sharon

doi:10.1080/23744235.2016.1262058

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…[3,4] A handful of case reports describing disseminated NTMIs in patients with SCD have been published. [6][7][8][9][10] Our report adds to the current literature, suggesting that SCD with iatrogenic iron overload may be a risk factor for disseminated NTMIs. The mechanism of this risk is unclear.…”

Section: Discussionmentioning

confidence: 50%

“…[22] Regarding mycobacterial infections specifically, a small study of 16 patients suggested that CICVCs increase the risk for blood-stream NTMIs. [10] The same study also suggested that the presence of SCD was a risk factor for NTMIs independent of CICVCs. [10] HU is used in SCD because of its ability to increase fetal hemoglobin levels by incompletely understood mechanisms.…”

Section: Discussionmentioning

confidence: 89%

“…[10] The same study also suggested that the presence of SCD was a risk factor for NTMIs independent of CICVCs. [10] HU is used in SCD because of its ability to increase fetal hemoglobin levels by incompletely understood mechanisms. [23] HU is a cytotoxic drug that can rarely cause myelosuppression.…”

Section: Discussionmentioning

confidence: 89%

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Disseminated Mycobacterium avium infection in a young woman with sickle cell disease and iatrogenic iron overload

Hosseini

Mantha

Koh

et al. 2021

CRIM

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A 29-year-old woman with known sickle cell disease (SCD) and iatrogenic iron overload presented to the emergency department with a recurrent pain crisis and fever. Blood cultures obtained at a recent prior admission for the same complaints grew M avium. Bone marrow biopsy revealed non-caseating granulomas, but stains for mycobacteria and fungi were negative. Disseminated non-tuberculous mycobacterial infections (NTMIs) occur almost exclusively in immunosuppressed patients. SCD is not considered a risk factor for the development of disseminated NTMIs, making diagnosis challenging in this population. However, a number of case reports describing disseminated NTMIs in patients with SCD have been published. This case adds to the current literature, suggesting SCD with iatrogenic iron overload is a possible risk factor for disseminated NTMIs. Potential mechanisms for this increased risk include 1) functional asplenia, 2) iatrogenic iron overload, 3) chronic indwelling central venous catheters, and 4) hydroxyurea use. Further investigation is required to describe the strength and mechanism of the relationship between SCD and disseminated NTMIs.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 89%

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Disseminated Mycobacterium avium infection in a young woman with sickle cell disease and iatrogenic iron overload

Hosseini

Mantha

Koh

et al. 2021

CRIM

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“…Several studies indicate an increased risk for catheter site infection and subsequent bacteremia in immunocompromised hosts [15, 16]. In these situations, M. fortuitum , M. mucogenicum , and M. chelonae were often implicated.…”

Section: Intravascular Catheter and Injection-associated Ntm Infectionsmentioning

confidence: 99%

“…While intravascular catheter-associated NTM infections remain rare, there have been increasing reports implicating rapidly growing mycobacteria. Several studies indicate an increased risk for catheter site infection and subsequent bacteremia in immunocompromised hosts [15, 16]. In these situations, M. fortuitum , M. mucogenicum , and M. chelonae were often implicated.…”

Section: Intravascular Catheter and Injection-associated Ntm Infectionsmentioning

confidence: 99%

Infections and Outbreaks of Nontuberculous Mycobacteria in Hospital Settings

Desai

Hurtado

2018

Curr Treat Options Infect Dis

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Purpose of review: Non-tuberculous mycobacterial [NTM] infections in the hospital setting are a complex and often challenging entity. The goal of this review is to discuss diagnostic and treatment strategies for established as well as emerging nosocomial NTM infections. Recent findings: NTM outbreaks have been documented in a variety of hospital settings. Contamination of medical devices or aqueous solutions is often implicated in the spread of infection. More recently, the slow grower M. chimaera has been reported in the setting of contaminated heater-cooler devices used for cardiopulmonary bypass and extracorporeal membrane oxygenation. In addition, increases in medical tourism for cosmetic surgery have led to outbreaks of rapidly growing mycobacteria. Summary: Diagnosis and treatment of nosocomial NTM pose many challenges for the clinician. Surgical resection or debridement as well as combination antimycobacterial therapy are a mainstay in therapeutic management. Strict infection control and prevention practices are critical to the identification and cessation of outbreaks.

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Bloodstream Infections Caused by Waterborne Bacteria

Gomez-Gomez

Volkow-Fernández

Cornejo‐Juárez

2020

Curr Treat Options Infect Dis

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Non-tuberculousmycobacterialbloodstream infections in patients with indwelling vascular catheters – the role of sickle cell anaemia

Abstract: IDVCs are a risk factor for NTM BSI. Sickle cell anaemia appears to be a risk factor for IDVC infections due to NTM. This study is limited by the small sample size. A larger study is needed to further investigate the association between HbSS/SC and NTM IDVC infections.

Cited by 6 publications

References 24 publications

Disseminated Mycobacterium avium infection in a young woman with sickle cell disease and iatrogenic iron overload

Disseminated Mycobacterium avium infection in a young woman with sickle cell disease and iatrogenic iron overload

Infections and Outbreaks of Nontuberculous Mycobacteria in Hospital Settings

Bloodstream Infections Caused by Waterborne Bacteria

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