The effective field theory (EFT) of inflation provides an essential picture to explore the effects of the unknown high energy physics in the single scalar field inflation models. For a generic EFT of inflation, possible high energy corrections to simple slow-roll inflation can modify both the propagating speed and dispersion relations of the cosmological scalar and tensor perturbations. With the arrival of the era of precision cosmology, it is expected that these high energy corrections become more important and have to be taken into account in the analysis with future precise observational data. In this paper we study the observational predictions of the EFT of inflation by using the third-order uniform asymptotic approximation method. We calculate explicitly the primordial power spectra, spectral indices, running of the spectral indices for both scalar and tensor perturbations, and the ratio between tensor and scalar spectra. These expressions are all written in terms of the Hubble flow parameters and the flow of four new slow-roll parameters and expanded up to the next-to-leading order in the slow-roll expansions so they represent the most accurate results obtained so far in the literature. The flow of the four new slow-roll parameters, which arise from the four new operators introduced in the action of the EFT of inflation, can affect the primordial perturbation spectra at the leading-order and the corresponding spectral indices at the next-to-leading order. *