Non-uremic calciphylaxis in a female patient with rheumatoid arthritis

Ruiz, Carolina Martínez; Poveda, Paula Molés; Solís, Nerea Barrado; Carpio, Enrique Gimeno

doi:10.1016/j.medcle.2016.04.029

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2017

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“…Rarely, calciphylaxis occurs in the absence of underlying renal failure. NUC is most frequently associated with primary hyperparathyroidism; however, it has also been reported with rheumatoid arthritis, administration of warfarin and glucocorticoids, and malignancy including breast carcinoma, Hodgkin lymphoma, metastatic melanoma and myeloma . To our knowledge, this is the first report of NUC in association with lymphocytic leukemia.…”

Section: Discussionmentioning

confidence: 75%

Pseudoxanthoma elasticum‐like changes in nonuremic calciphylaxis: Case series and brief review of a helpful diagnostic clue

et al. 2017

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Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life-threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings.

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Section: Discussionmentioning

confidence: 75%