Non-variceal upper gastrointestinal bleeding in cirrhotic patients in Nile Delta

Gabr, Mamdouh; Tawfik, Mohamed A; El-Sawy, Abd Allah Ahmed

doi:10.1007/s12664-016-0622-7

Cited by 14 publications

(18 citation statements)

References 18 publications

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“…This may be explained by the fact that viral liver disease is much more prevalent in our younger population. Our results are somewhat compatible to four studies: Romcea et al 13 , Svoboda et al 19 , GonzálezGonzález et al 20 , and Gabr et al 16 (56.76, 56.9, 56.5 and 58.57 years old, respectively). The vast majority (75%) of cases of cirrhosis were due to HCV, which was comparable to some 16 , however it contradicts the many western studies in which alcohol is the most common cause of cirrhosis.…”

Section: Discussionsupporting

confidence: 93%

“…The demographic analysis of our study revealed that AUGIB is much more common in male cirrhotic patients as compared to female patients (62.4% versus 37.6%, p<0.0001) and this is compatible with many other studies. 13,14,15,16 Mean age at presentation in some studies is around 65-70 years. 17,18 In contrast to these studies mean age of cirrhotic patients presenting with AUGIB in our study was 50.15 years.…”

Section: Discussionmentioning

confidence: 99%

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Frequency of fundal varices in cirrhotic patients with upper gastrointestinal bleed.

Malghani

Chaudhary

Din

et al. 2019

TPMJ

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Objectives: Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency in cirrhosis. These patients mainly bleed from esophageal varices. The aim of the present work was to determine the prevalence of fundal varices; gastro-oesophageal varices type2 (GOV-2) and isolated gastric varices type1 (IGV-1), as a cause of AUGIB. Study Design: Cross-sectional study. Setting: Gastroenterology Department of Nishtar Hospital Multan, Pakistan, using non-probability consecutive sampling. Period: July to December 2018. Material and Methods: Emergency upper gastrointestinal (UGI) endoscopy was performed in 165 cirrhotic patients and the findings documented. Results: The mean age was 50.15 ± 12.72 years. There were 103 (62.4%) males and 62 (37.6%) females (p<0.0001). Hepatitis C virus (HCV) was the cause of cirrhosis in 75%, followed by HBV in 10% and HBV & HCV co-infection in 6%. Bleeding fundal varices were found in 25 (15%) patients, 15 IGV-1 and 10 GOV-2. Other major causes of bleeding included: esophageal varices 93 (56.4%) and portal hypertensive gastropathy (PHG) 33 (20%). All fundal varices were found in advanced liver disease patients (p<0.05). Conclusion: AUGIB is more common in males and advance liver disease. Although not frequent, fundal varices are an important cause of AUGIB, with a strong association with severity of cirrhosis. Our study demonstrates a higher prevalence of fundal varices (especially IGV-1) than other studies.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Frequency of fundal varices in cirrhotic patients with upper gastrointestinal bleed.

Malghani

Chaudhary

Din

et al. 2019

TPMJ

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“…Mortality had no significant correlation to source of bleeding variceal or non variceal, rebleeding, intervention during endoscopy, grade of EV, or PHG, grade of encephalopathy, presence of focal lesion, portal vein patency, or use of NSAID's. [11]. All these studies say that the males are more at risk of upper GI bleeding than females.…”

Section: Resultsmentioning

confidence: 99%

Non-variceal Causes and Outcome of Acute Upper Gastro-intestinal bleeding among Cirrhotic Patients in Tropical Medicine Intensive Care Unit

Farag

Jouda

Moustafa

et al. 2019

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…Acute upper gastrointestinal bleeding (UGIB) is the most common gastroenterological emergency in patients with cirrhosis and correlated with significant morbidity and mortality [1,2]. Acute variceal bleeding (AVB) is the leading cause of UGIB in cirrhosis and account for up to 70% of all cases [3,4], while non variceal bleeding (NVB) is a considerable cause of UGIB and responsible for the remaining cases, with the most frequent being peptic ulcer disease (PUD) [5]. In recent years significant amelioration in the therapeutic management of UGIB and improvement of hemostatic therapies resulted in a reduction of mortality and improvement of prognosis whether the cause is variceal [6,7] or non-variceal [7,8] Observational studies have demonstrated the higher mortality rate among patients with a bleeding Peptic ulcer with cirrhosis than in those without liver disease [9,10].…”

Section: Introductionmentioning

confidence: 99%

Upper gastrointestinal bleeding in patients with liver cirrhosis, Is the difference of clinical outcomes depend on the source?

Mohamed

Elgohary

Bassiony

et al. 2020

Preprint

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Background and Study Aims Acute upper gastrointestinal bleeding (UGIB) is the most common gastroenterological emergency in patients with cirrhosis; It increases the hospital length of stay (LOS), and Chance of 30-day hospital readmission. It has not been clarified if there is a difference in the prognosis of UGIB in cirrhosis depending on the source of bleeding. We aimed to investigate clinical outcomes in patients with cirrhosis with either acute variceal bleeding (AVB) or non-variceal bleeding (NVB) and risk factors for prolonged hospital LOS in both groups.Patients and Methods From July 2016 to January 2017, all adult eligible patients hospitalized with cirrhosis and UGIB were enrolled in the retrospective study, we assessed clinical outcomes in both groups and factors associated with prolonged hospital LOS.Results Of the 608 patients included in the study, 416 had variceal and 192 non-variceal bleeding. Mortality was higher in AVB group compared to NVB (12.5% vs. 8.3%, P= 0.023). There was a trend towards increased the length of hospital stay for those who had an AVB compared to NVB (5.84±2.16 vs. 4.33±1.18, p=0.001). Rate of hospital Readmission was also higher in the AVB group. Risk factors for prolonged hospital LOS were in hospital rebleeding, presence of Hepatic encephalopathy or ascites, higher MELD score and Patients with child score B, C.Conclusion Patients with cirrhosis and AVB have higher mortality rate, longer hospital LOS and re-hospitalization rate than those with NVB.

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Non-variceal upper gastrointestinal bleeding in cirrhotic patients in Nile Delta

Abstract: Non-variceal bleeding in cirrhosis was not frequent, and sources included peptic ulcer, portal hypertensive gastropathy, and erosive disease of the stomach and duodenum.

Cited by 14 publications

References 18 publications

Frequency of fundal varices in cirrhotic patients with upper gastrointestinal bleed.

Frequency of fundal varices in cirrhotic patients with upper gastrointestinal bleed.

Non-variceal Causes and Outcome of Acute Upper Gastro-intestinal bleeding among Cirrhotic Patients in Tropical Medicine Intensive Care Unit

Upper gastrointestinal bleeding in patients with liver cirrhosis, Is the difference of clinical outcomes depend on the source?

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