The critical association of connective tissue growth factor (CTGF), which is thought to be one of the downstream mediators of transforming growth factor- (TGF-), with vitreoretinal diseases remains to be clarified. In the current study, we first demonstrated the correlation between the concentrations of TGF-2 as well as CTGF in the vitreous and CTGF gene regulation in cultured hyalocytes.
Concentrations of TGF-2 and CTGF in the vitreous