Non-verified tick-borne infections

Семенов, В. А.; Khokhlova, Z. A.; Этенко, Д. А.; Bondarenko, Tatyana E.; Kudasheva, Svetlana E.; Starchenkova, Tatyana E.

doi:10.33029/2305-3496-2020-9-4-103-109

Cited by 3 publications

(1 citation statement)

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“…присасывания клеща [14]. риккетсиоз и бабезиоз являются примерами патологий, для которых существует диссонанс между количеством выявленных случаев заболевания и результатами исследований, подтверждающими факт существования природных очагов на отдельных территориях.…”

Section: результаты и обсуждениеunclassified

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Voronkova,

Romanenko,

Simakova

et al. 2023

Problemy Osobo Opasnykh Infektsii

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The aim of the study was to characterize mono- and mixed infection with causative agents of vector-borne infections in Dermacentor reticulatus ticks inhabiting one of the anthropourgic foci of the Tomsk Region. Materials and methods. D. reticulatus ticks were collected from vegetation “on the flag” in the forest park zones of the southern part of Tomsk in August and September, 2020–2021. To isolate nucleic acids from homogenates of mites and subsequent PCR diagnostics, kits of the RealBest series (“Vector-Best”, Novosibirsk) were used. 184 individual samples of nucleic acids were examined for the presence of molecular-genetic markers of tick-borne encephalitis virus (TBEV), pathogenic borrelia, babesia, rickettsia, anaplasma, and ehrlichia. Results and discussion. The spectrum of pathogens detected through PCR assay of ticks collected in one of the anthropurgic foci of the Tomsk Region in 2020 and 2021 includes TBEV, pathogenic borrelia, rickettsia, and babesia. The highest rate of D. reticulatus infection has been established in relation to candidate pathogens of tick-borne rickettsioses (Rickettsia sp.) and babesioses (Babesia sp.). The overall frequency of co-infection in D. reticulatus was 12.88 %. Seven different associations of pathogens infecting D. reticulatus have been identified. The majority (88.24 %) of the detected cases of mixed infection were rickettsia associations. Double infection has been registered in 94 % of the total number of mixed variants. Markers of four tick-borne infection pathogens simultaneously (Rickettsia species DNA, Babesia species DNA, Borrelia burgdorferi s.l. DNA and TBEV RNA) have been found in one sample. Changes in areal of the D. reticulatus against the background of an increase in their numbers, determines the need to analyze the epidemiological significance of the ticks of this species in combined foci of tick-borne infections, especially in the zone of sympatry with ixodic ticks of other species.

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Section: результаты и обсуждениеunclassified

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Voronkova,

Romanenko,

Simakova

et al. 2023

Problemy Osobo Opasnykh Infektsii

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Analysis of leukogram parameters and blood cytokine profile in tick-borne infections of various etiologies

Воронкова

Ilyinskikh

Hasanova³

et al. 2023

Russian Journal of Infection and Immunity

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Introduction. Studies aimed at identifying pathogenetic features of tick-borne natural focal infections depending on etiological agent are relevant to seek out for new associations of biomarkers characterizing the structural and functional phenotype of immune cells significant for the differential diagnosis and prognosis of diseases. The aim of the study was to evaluate the parameters of a leukogram with an expanded profile in relation to the parameters of cytokine status in patients with viral tick-borne encephalitis as well as erythemic tick-borne borreliosis at acute stage of the disease. Materials and methods. The study involved 28 patients with the non-erythemic tick-borne borreliosis and 27 patients with tick-borne encephalitis at the acute stage of the disease, as well as 16 healthy individuals (control group). Venous blood samples were examined using a Sysmex XN1000 analyzer based on reflex testing technology with extended profile allowing to characterize leukocyte reaction during infection and inflammation, including parameters such as the absolute and relative count of immature granulocytes (IG), neutrophil granularity index (NEUT-GI), neutrophil reactivity index (NEUT-RI), count of reactive lymphocytes (RE-LYMP), count of antibody-producing lymphocytes (AS-LYMP). Concentration of IL-2, -4, -6, -8, -10, IFN and TNF in blood serum was determined by enzyme immunoassay using specific reagent kits (Vector-Best, Russia). Results. It was found that changes in the quantitative composition of blood leukocytes in patients with viral tick-borne encephalitis and non-erythemic form of tick-borne borreliosis have a unidirectional tendency characterized by increased count of metabolically active neutrophils (NEUT-RI) and a decreased count of reactive lymphocytes (RE-LYMP) compared to healthy individuals. Changes in the leukogram occur along with high blood concentration of proinflammatory cytokines IL-8 and TNF and a low level of IFN. A positive direct correlation was revealed between the fluorescence intensity parameter characterizing the metabolic activity of neutrophil granulocytes (NEUT-RI) and blood serum IL-8 level both in tick-borne encephalitis (r=0.422, p0.05) and non-erythemic form of tick-borne borreliosis (r=0.551, p0.05). Additionally, in the former, a positive correlation was established between the total leukocyte count (WBC) and concentration of TNF in the blood serum (r=0.532, p0.05).

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Characteristic features of febrile states in infectious diseases transmitted by tick bites

Bondarenko

Khokhlova²,

Кудашева

et al. 2022

jour

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Infections associated with the suction of ticks, the so-called tick fever, refer to natural focal diseases and are seasonal in nature. Currently, it is known that ticks are carriers of a number of viruses, bacteria, spirochetes that cause diseases in humans. The diagnosis for a signifi cant part of these infections remains unverifi ed. A common clinical symptom for all infections caused by ticks is fever, which is part of the general infectious (febrile-toxic) syndrome, which, in turn, may have features inherent in one or another infection. This review provides clinical characteristics of tick-caused infections registered in Russia: febrile tick-born encephalitis, ixodic tick-born borreliosis, babesiasis, ehrlichiosis, tick-born rickettsial disease, hemorrhagic fevers, tularemia, bartonellosis. The basic criteria for the diff erential diagnosis of general infectious syndrome as the main manifestation of the onset of these diseases are presented. It is shown that due to the similarity of symptoms, especially in mixed-type foci, specifi c laboratory diagnostics should be regarded as determinative in diagnosis

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Non-verified tick-borne infections

Cited by 3 publications

References 0 publications

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Analysis of Multiple Infection in Ixodic Ticks <i>Dermacentor reticulatus</i> in a Combined Natural Focus of Vector-Borne Infections in the Tomsk Region

Analysis of leukogram parameters and blood cytokine profile in tick-borne infections of various etiologies

Characteristic features of febrile states in infectious diseases transmitted by tick bites

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