2018
DOI: 10.3389/fcimb.2018.00315
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Non-vesicular Lipid Transport Machinery in Entamoeba histolytica

Abstract: Eukaryotic cells are organized into separate membrane-bound compartments that have specialized biochemical signature and function. Maintenance and regulation of distinct identity of each compartment is governed by the uneven distribution and intra-cellular movement of two essential biomolecules, lipids, and proteins. Non-vesicular lipid transport mediated by lipid transfer proteins plays a pivotal role in intra-cellular lipid trafficking and homeostasis whereas vesicular transport plays a central role in prote… Show more

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Cited by 11 publications
(25 citation statements)
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References 147 publications
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“…In E. histolytica, PI(4,5)P 2 is formed by the action on EhPIPKI enzyme and it binds to the cytoskeleton to maintain the cell shape and integrity (Sharma et al, 2019). PI(4,5)P 2 is present in lipid rafts, where may regulate parasite motility (Das and Nozaki, 2018). PI(3,4,5)P 3 has not been detected in most of the unicellular organisms, but it has been identified in E. histolytica and Plasmodium (Tawk et al, 2010).…”
Section: Pi and Phosphoinositides In Virulencementioning
confidence: 99%
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“…In E. histolytica, PI(4,5)P 2 is formed by the action on EhPIPKI enzyme and it binds to the cytoskeleton to maintain the cell shape and integrity (Sharma et al, 2019). PI(4,5)P 2 is present in lipid rafts, where may regulate parasite motility (Das and Nozaki, 2018). PI(3,4,5)P 3 has not been detected in most of the unicellular organisms, but it has been identified in E. histolytica and Plasmodium (Tawk et al, 2010).…”
Section: Pi and Phosphoinositides In Virulencementioning
confidence: 99%
“…These proteins can be classified in 15 START-domaincontaining proteins that bind to sterols, phospholipids or ceramides; four candidates with ORD-domain which binds to sterols and phosphatidylinositol-4 phosphate, two proteins with Sec14-domain that is known to bind to phosphatidylcholine (PC) and phosphatidylinositides, and a single PRELI-domaincontaining protein that transfer phosphatidic acid (PA). All these data suggest the presence of a well-organized machinery for lipid transport in E. histolytica (Das et al, 2002;Das and Nozaki, 2018). However, experimental data are needed to prove this.…”
Section: Introductionmentioning
confidence: 95%
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“…Three hydroxyl groups of the D- myo -inositol head group (D3–5) are independently phosphorylated or dephosphorylated to form seven kinds of phosphorylated PtdIns (PIs) (Figure 1). PtdIns is synthesized in the endoplasmic reticulum (ER) from cytidine diphosphate diacylglycerol (CDP-DAG) and myo -inositol by PtdIns synthase (PIS) and transported to other cellular compartments either by vesicular transport or by PI transfer proteins (PITPs) (Di Paolo and De Camilli, 2006; Lev, 2010; Das and Nozaki, 2018). PtdInss are further metabolized to a variety of PIs on the membranes of these organelles (Figure 1).…”
Section: General Overview On Intracellular Localization and Roles mentioning
confidence: 99%
“…E. histolytica possesses full capacity of de novo biosynthesis of phospholipids including phosphatidylcholine and phosphatidylethanolamine [52] and the ability to scavenge components from the environment under in vitro cultivation conditions [53]. Furthermore, Entamoeba possesses a list of lipid binding proteins in their genome [54,55]; one of such lipid transfer proteins, EhPCTP-L, was shown to bind phosphatidylserine and phosphatidic acid and localizes to the cell surface [56]. The catalytic P4-ATPase subunit of the phospholipid flipase responsible for miltefosine transport should be identified to better understand the molecular mechanisms of phospholipid transport on the plasma membrane and its involvement in drug resistant and pathogenesis in Entamoeba .…”
Section: Discussionmentioning
confidence: 99%