Non-vestibular head and neck schwannomas: a 10-year experience

Bondi, Stefano; Limardo, Pietro; Toma, Salvatore; Bussi, Mario

doi:10.1007/s00405-013-2520-2

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…VS represents 8% of all primary intracranial tumors (1). Individuals between 30 and 60 years old are the most frequently affected, and there is no gender prevalence (2,3). The majority of VSs are sporadic and, in general, are benign slow-growing neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical profile of cytokines and growth factors expressed in vestibular schwannoma and in normal vestibular nerve tissue

Taurone

Bianchi

Attanasio

et al. 2012

Molecular Medicine Reports

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Vestibular schwannomas, also known as acoustic neuromas, are benign tumors, which originate from myelin-forming Schwann cells. They develop in the vestibular branch of the eighth cranial nerve in the internal auditory canal or cerebellopontine angle. The clinical progression of the condition involves slow and progressive growth, eventually resulting in brainstem compression. The objective of the present study was to investigate the expression level and the localization of the pro-inflammatory cytokines, transforming growth factor-β1 (TGF-β1) interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α), as well as the adhesion molecules, intracellular adhesion molecule-1 and vascular endothelial growth factor (VEGF), in order to determine whether these factors are involved in the transformation and development of human vestibular schwannoma. The present study investigated whether changes in inflammation are involved in tumor growth and if so, the mechanisms underlying this process. The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-β1, IL-1β and IL-6 exhibited increased expression in human vestibular schwannoma tissue compared with normal vestibular nerve samples. TNF-α was weakly expressed in Schwann cells, confirming that a lower level of this cytokine is involved in the proliferation of Schwann cells. Neoplastic Schwann cells produce pro-inflammatory cytokines that may act in an autocrine manner, stimulating cellular proliferation. In addition, the increased expression of VEGF in vestibular schwannoma compared with that in normal vestibular nerve tissue, suggests that this factor may induce neoplastic growth via the promotion of angiogenesis. The present findings suggest that inflammation may promote angiogenesis and consequently contribute to tumor progression. In conclusion, the results of the present study indicated that VEGF and pro-inflammatory cytokines may be potential therapeutic targets in vestibular schwannoma. Further studies are necessary to confirm the involvement of these factors in the growth of neoplasms and to develop inhibitors of pro-inflammatory cytokines as a potential treatment option in the future.

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Section: Introductionmentioning

confidence: 99%

Immunohistochemical profile of cytokines and growth factors expressed in vestibular schwannoma and in normal vestibular nerve tissue

Taurone

Bianchi

Attanasio

et al. 2012

Molecular Medicine Reports

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“…Ultrasound scan with fi ne needle aspiration biopsy can be diagnostic in 30% and magnetic resonance imaging in 77% of cases [12]. Ultrasound scans show homogenous and hypo-echogenic fi ndings and post-acoustic enhancement.…”

Section: Discussionmentioning

confidence: 99%

Schwannoma of the upper lip: A case report and literature review

et al. 2017

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Introduction Schwannomas or neurilemmomas are well demarcated, benign neurogenic lesions arising by a fibroblastic proliferation of the nerve sheath cell (Schwann cell). They usually present as solitary encapsulated lesions with rare occurrence in the upper lip. Non-diagnosed or misdiagnosed schwannomas present a high risk for the tumor to continue growing and exerting pressure on surrounding nerves. These tumours based on their location could lead to facial weakness and paralysis, pressure in ears, tinnitus, hearing loss, balance loss, and could lead to a life-threatening situation. Case Outline This case is a rare presentation of a schwannoma located in the upper lip of a 21-year-old male patient of Indian origin. The patient complained of a swelling in the mouth with a difficulty in keeping the mouth closed. The swelling was surgically excised and the patient healed completely. Conclusion This case of occurrence of tumor on the upper lip points to the possibility of considering schwannoma as a possibility in the diagnosis of oral tumors in the future, as the location of the tumor was rare and had a high chance of misdiagnosis.

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“…The remaining nerve fascicles are contained within the epineurium and, in most instances, are functional 10. Bondi et al 10 described methods of dissecting the healthy fascicles with longitudinal incisions on the nerve and then exposing the tumour. Their experience with 18 patients confirmed minimal neurological deficit after such procedures 10…”

Section: Discussionmentioning

confidence: 99%