Nonablative 1550-nm fractional laser therapy versus triple topical therapy for the treatment of melasma: A randomized controlled pilot study

Kroon, Marije W.; Wind, Bas S.; Beek, Hans van; Veen, J.P.W. van der; Nieuweboer‐Krobotova, L.; Bos, Jan D.; Wolkerstorfer, Albert

doi:10.1016/j.jaad.2010.01.048

Cited by 65 publications

(54 citation statements)

References 22 publications

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“…A direct comparison between NAFL with 1550 nm and triple therapy topical cream to treat melasma was completed in a randomized, controlled, observer-blinded study by Kroon et al (2011). Twenty female patients with Fitzpatrick skin types II to IV either applied a mixture of 5% hydroquinone, 0.05% tretinoin, and 0.1% triamcinolone acetonide cream once daily for 8 weeks or received laser treatment once every 2 weeks for a total of 4 treatments.…”

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

“…The study investigators concluded that therapy with 1550 nm NAFL was safe and comparable in efficacy and recurrence rate with triple topical therapy. It may be a useful alternative treatment option for patients with melasma when topical bleaching is ineffective or not tolerated (Kroon et al, 2011). …”

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

“…Wind et al (2010) performed a similar randomized study but used a split-face approach where one side of the face was treated with 1550 nm NAFL for four to five sessions and the opposite side of the face received a triple therapy topical melasma cream (i.e., the same cream used by Kroon et al, 2011). The mean physician global assessment and patient satisfaction scores were significantly lower for the side that was treated with the laser and 31% of patients were reported with PIH.…”

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

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A review of laser and light therapy in melasma

Trivedi

Yang

Cho³

2017

International Journal of Women's Dermatology

140

135

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Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Intense pulsed light, low fluence Q-switched lasers, and non-ablative fractionated lasers are the most common lasers and light treatments that are currently performed. They all appear effective but there is a high level of recurrence with time and some techniques are associated with an increased risk for postinflammatory hyper- or hypopigmentation. The number and frequency of treatments varies by device type but overall, Q-switched lasers require the greatest number of treatment applications to see a benefit. Vascular-specific lasers do not appear to be effective for the treatment of melasma. Ablative fractionated lasers should be used with caution because they have a very high risk for postinflammatory hypo- and hyperpigmentation. The use of nonablative fractionated laser treatments compared with other laser and light options may result in slightly longer remission intervals. Picosecond lasers, fractional radiofrequency, and laser-assisted drug delivery are promising future approaches to treat melasma. The goal of this review is to summarize the efficacy and safety of the most commonly used laser and light therapies to treat melasma, briefly present future laser-based treatment options for patients with melasma, and provide recommendations for treatment on the basis of the reviewed information.

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Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

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A review of laser and light therapy in melasma

Trivedi

Yang

Cho³

2017

International Journal of Women's Dermatology

140

135

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“…[1] It occurs almost exclusively in the sun exposed area, especially those living in areas of intense ultraviolet radiation. [2]…”

Section: Introductionmentioning

confidence: 99%

Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%) Versus Glycolic Acid (50%) Peeling Agent in the Treatment of Female Patients with Facial Melasma

et al. 2017

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Background:Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid.Materials and Methods:This clinical trial was performed, on 42 female patients with bilateral melasma. Severity of melasma was assessed by melasma area and severity index (MASI). Combination of (20% azelaic acid + 10% resorcinol + 6% phytic acid) was used as a new peeling agent on the right side of the face and 50% glycolic acid on the left side every 2 weeks for 6 times. Follow-up was carried out for 3 months after the last session. Any decrease in MASI score and unwanted complications following peeling were evaluated and compared during the trial.Results:Patients showed marked improvement as calculated with MASI score before and after treatment in both sides of the face. The efficacy of combination formula (azelaic acid, resorcinol and phytic acid) was similar to glycolic acid, but with fewer complications. There was no statistically difference in improvement between two groups (P > 0.05). However, the patient's discomfort following procedures was significantly lower with azelaic acid, resorcinol and phytic compared with the glycolic acid peels (P < 0.05) and there was the same duration in the beginning of the therapeutic response in both groups.Conclusion:Results showed that triple-combination was found to be an effective and safe peeling agent in the treatment of melasma and it was as effective as 50% glycolic acid peel.

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“…They reported some adverse effects such as pain, burning sensation, and erythema after laser therapy; nevertheless, they recommended such a laser therapy as a safe and acceptable treatment for melasma. 12 Wind et al compared fractionated nonablative 1550-nm erbium laser with TTC and reported significantly lower GPA and satisfaction as well as high rate of hyperpigmentation (31%) in the laser-treated sides and hence, did not recommend such a therapy for melasma. 13 While laser therapies are associated with adverse effects such as burn and erythema and might induce post inflammatory hyperpigmentation, their usage in dermatology and cosmetic procedures is increasing.…”

Section: Discussionmentioning

confidence: 99%

Combination of Q-Switched Nd:YAG and Fractional Erbium:YAG Lasers in Treatment of Melasma: A Randomized Controlled Clinical Trial

et al. 2017

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Introduction: Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma. Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Women with melasma and without a history of keloid formation, hypersensitivity to hydroquinone, or pigmentary changes due to laser therapy were randomly allocated to receive four sessions of either QSNYL-FEYL combination or QSNYL alone. All patients received topical treatment with Kligman's formula. Before laser therapy and 4 weeks after the last treatment session, patients' skin was assessed for changes in skin color, melanin content, and erythema intensity of melasma lesions quantitatively. ; P < 0.001). After adjustment for baseline values, the post treatment intensity of erythema was significantly lower in QSNYL-FEYL group (P < 0.001). The patients reported no adverse events. Conclusion: QSNYL-FEYL was significantly more effective in decreasing melanin content of lesions than QSNYL and led to a lighter skin.

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Nonablative 1550-nm fractional laser therapy versus triple topical therapy for the treatment of melasma: A randomized controlled pilot study

Cited by 65 publications

References 22 publications

A review of laser and light therapy in melasma

A review of laser and light therapy in melasma

Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%) Versus Glycolic Acid (50%) Peeling Agent in the Treatment of Female Patients with Facial Melasma

Combination of Q-Switched Nd:YAG and Fractional Erbium:YAG Lasers in Treatment of Melasma: A Randomized Controlled Clinical Trial

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