Nonablative Dermal Remodeling With a 585–nm, 350–μsec, Flashlamp Pulsed Dye Laser

Goldberg, David J.; Tan, Mei‐Heng; Sarradet, M.D.; Gordon, Marsha

doi:10.1046/j.1524-4725.2003.29040.x

Cited by 37 publications

(27 citation statements)

References 16 publications

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“…In this same study, pre-and posttreatment measurements of skin transepidermal water loss (an estimate of the epidermal barrier function) showed no change over time, which implies that there was no compromise in barrier function as a result of these treatments. In a later study [64], pre-treatment and 6 month post-treatment biopsies were harvested from preauricular sites, and collagen fiber size was evaluated by electron microscopy. After 6 months, an increase in both the quantity per unit volume of small collagen fibers consistent with type III collagen and larger fibers consistent with growth in type I collagen were observed.…”

Section: Pulsed-dye Lasermentioning

confidence: 99%

Nonablative laser and light treatments: Histology and tissue effects—A Review

et al. 2003

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(a) Thermal injury to the dermis in association with epidermal cooling most likely affects the dermal vasculature, which initiates a cascade of inflammatory events that includes fibroblastic proliferation and apparent up-regulation of collagen expression; (b) There is no indication that nonablative treatments are harmful or able to induce skin cancer; (c) It is possible that the horizontally distributed collagen reported after nonablative treatments is a "microscar," an enlarged Grenz sone associated with repetitive photo-induced trauma; (d) Further research is needed to elucidate the biophysical mechanisms underlying nonablative treatment, as well as to distinguish the utility of different wavelengths on epidermal and dermal improvement.

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Section: Pulsed-dye Lasermentioning

confidence: 99%

Nonablative laser and light treatments: Histology and tissue effects—A Review

et al. 2003

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“…Electron microscopy studies of nonablative lasers such as the 585-nm flashlamp pulsed dye laser have shown a decrease in diameter of dermal collagen fibers after nonablative laser therapy. 10 A decrease in collagen fiber diameter has been associated with production of new collagen, 8,9 which is thought to increase skin firmness and improve skin texture in patients after treatment.…”

Section: B O T H N a N O S E C O N D (Q-mentioning

confidence: 99%

Nonablative Facial Remodeling

Schmults¹,

Phelps²,

Goldberg³

2004

Arch Dermatol

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Background: A variety of nonablative lasers have been used to improve skin color and toning. Evidence of new collagen has been seen. Using blinded observer analysis of electron microscopic changes, we have documented the effect of a nonablative Nd:YAG laser on collagen production and its relationship to patient age.Observations: Ultrastructural analysis of 9 patients showed a decrease in overall collagen fiber diameter in the papillary dermis at 1 month and 3 months after 3 treatment sessions. This is consistent with the formation of new collagen. Younger patients had a greater decrease in collagen fiber diameter compared with older patients. The change in collagen fiber diameter with time as well as the relationship between that change and the patient's age were statistically significant (PϽ.001). Photographic evaluation showed that those patients with preexisting erythema showed improvement in erythema along with an associated improvement in skin quality. There were no adverse events.Conclusions: Microsecond Nd:YAG lasers appear to be safe for nonablative laser remodeling. Our study indicates that microsecond Nd:YAG lasers can produce new collagen formation in the papillary dermis. In addition, the condition of patients with erythema may be improved. Younger patients may form more new collagen compared with older patients with photodamage.

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“…The clinical efficacy of these nonablative modalities are less than for the ablative methods, however, in one study up to 90% of the patients showed clinically observable improvement in wrinkles [10]. Other studies showed clinical effect in only 40% of the treated subjects [11].…”

Section: Introductionmentioning

confidence: 96%