Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study

Kim, Tae-In; Ahn, Hye‐Jin; Kang, In-Hye; Jeong, Ki‐Heon; Kim, Nack In; Shin, Min Kyung

doi:10.1111/phpp.12312

Cited by 23 publications

(31 citation statements)

References 18 publications

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“…According to our retrieval strategy, 786 potential articles were obtained. After screening, 13 trials [12][13][14][15][16][17][18][19][20][21][22][23][24] were enrolled in our meta-analysis, and the sample sizes in PDT and visible phototherapy alone or drug groups were 399 and 406, respectively. Figure 1 summarizes the article screening process.…”

Section: Study Characteristicsmentioning

confidence: 99%

Efficacy of photodynamic therapy for the treatment of inflammatory acne vulgaris: A systematic review and meta‐analysis

Tang

et al. 2019

J of Cosmetic Dermatology

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Acne vulgaris is a kind of chronic inflammatory dermal disorder that occurs in the sebaceous glands and hair follicles on face, neck, back, and chest, which has affected almost every adult and adolescent during their lifetime at a certain time. 1,2 Studies have shown that the incidence of acne is as high as 85%, which has greatly affected the psychology and quality of life of patients even though it is not life-threatening. 3 The clinical features of acne include seborrhea, noninflammatory lesion (including closed or open comedone), inflammatory lesion (pustule and papule), and scarring to different extents. Acne has complex pathogenesis. Currently, the occurrence and development of acne are found to be related to factors such as massive secretion of sebum under the action of androgen, the change in sebum composition, the abnormal keratosis of hair follicles and sebaceous glands, the

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Section: Study Characteristicsmentioning

confidence: 99%

Efficacy of photodynamic therapy for the treatment of inflammatory acne vulgaris: A systematic review and meta‐analysis

Tang

et al. 2019

J of Cosmetic Dermatology

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“…Yet, in line with the main finding of our study, this approach did not have a significant impact on efficacy outcomes, in this case, the development of new AKs. Nonablative fractional laser pretreatment before daylight PDT (dPDT) with MAL has been investigated vs dPDT alone in the treatment of moderate to severe facial acne vulgaris . Similarly, there was no significant difference in mean lesion counts between patients who received laser pretreatment and those who received dPDT alone; however, a significantly higher pain score was reported at the first visit by those receiving laser treatment .…”

Section: Discussionmentioning

confidence: 99%

“…Nonablative fractional laser pretreatment before daylight PDT (dPDT) with MAL has been investigated vs dPDT alone in the treatment of moderate to severe facial acne vulgaris . Similarly, there was no significant difference in mean lesion counts between patients who received laser pretreatment and those who received dPDT alone; however, a significantly higher pain score was reported at the first visit by those receiving laser treatment . A real‐world case series on the use of a similar nonablative fractional laser for photothermolysis prior to ALA–PDT for the treatment of acne vulgaris reported improved outcomes with this approach, including minimal adverse events and a reduced need for treatment sessions compared with ALA–PDT alone .…”

Section: Discussionmentioning

confidence: 99%

Split‐Sided Chest Study of Skin Rejuvenation Comparing Low‐Energy, 1,927‐nm Thulium Fractional Laser Treatment Prior to Photodynamic Therapy Versus Photodynamic Therapy Alone

et al. 2019

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Background and Objectives: Treatment of photoaging and intrinsic aging of the chest, with the associated concerns of skin roughness, uneven pigmentation, laxity, atrophy, and telangiectasias, can be problematic because of the potential for worsened esthetic outcomes with existing treatments. This study assessed the efficacy and safety of using nonablative fractional laser therapy (FLT) pretreatment with photodynamic therapy (PDT) versus PDT alone for chest rejuvenation. Study Design/Materials and Methods: In a randomized, evaluator-blinded, split-sided study, adult female patients with photodamage to the chest received three treatment courses over an 8-week period with follow-up visits at Weeks 12 and 20. FLT was applied to one side of the chest, randomly assigned at baseline, followed by aminolevulinic acid-based PDT, delivered using a thermal, short incubation, broad area technique, to both sides of the chest. In-person and photographic assessments were conducted using fivepoint scales to evaluate outcomes including rhytides, pigmentation, skin texture, and telangiectasias. Results: Eleven adults completed the study, of whom 11 had improved scores for rhytides and 10 had improved scores for skin texture at Week 20. There was no significant difference in any efficacy outcome between FLT and PDT and standard PDT alone. The severity of adverse events was rated significantly greater with the combined FLT-PDT treatment vs PDT alone. Conclusions: Significant improvements were observed vs baseline for both sides of the chest treated with FLT-PDT or standard PDT following three treatment sessions. No significant difference in efficacy was observed between treatment approaches, although adverse events were more severe on the FLT-pretreated side. This study was not registered as it qualified as a nonsignificant risk study. Lasers Surg. Med.

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“…ALA-PDT has proven to be an effective treatment for acne in several studies. [ 23 , 24 ] However, influence of PDT on patients’ QOL, and the combined effects of PDT and oral medication have rarely been studied.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life

Zheng²,

Zhao³

et al. 2017

Medicine

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Background:Acne vulgaris is a prevalent skin disorder impairing both physical and psychosocial health. This study was designed to investigate the effectiveness of photodynamic therapy (PDT) combined with minocycline in moderate to severe facial acne and influence on quality of life (QOL).Methods:Ninety-five patients with moderate to severe facial acne (Investigator Global Assessment [IGA] score 3–4) were randomly treated with PDT and minocycline (n = 48) or minocycline alone (n = 47). All patients took minocycline hydrochloride 100 mg/d for 4 weeks, whereas patients in the minocycline plus PDT group also received 4 times PDT treatment 1 week apart. IGA score, lesion counts, Dermatology Life Quality Index (DLQI), and safety evaluation were performed before treatment and at 2, 4, 6, and 8 weeks after enrolment.Results:There were no statistically significant differences in characteristics between 2 treatment groups at baseline. Minocycline plus PDT treatment led to a greater mean percentage reduction from baseline in lesion counts versus minocycline alone at 8 weeks for both inflammatory (−74.4% vs −53.3%; P < .001) and noninflammatory lesions (−61.7% vs −42.4%; P < .001). More patients treated with minocycline plus PDT achieved IGA score <2 at study end (week 8: 30/48 vs 20/47; P < .05). Patients treated with minocycline plus PDT got significant lower DLQI at 8 weeks (4.4 vs 6.3; P < .001). Adverse events were mild and manageable.Conclusions:Compared with minocycline alone, the combination of PDT with minocycline significantly improved clinical efficacy and QOL in moderate to severe facial acne patients.

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Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study

Abstract: DL-PDT with MAL shows clinically good responses to inflammatory lesions and is well tolerated in patients with moderate to severe acne.

Cited by 23 publications

References 18 publications

Efficacy of photodynamic therapy for the treatment of inflammatory acne vulgaris: A systematic review and meta‐analysis

Efficacy of photodynamic therapy for the treatment of inflammatory acne vulgaris: A systematic review and meta‐analysis

Split‐Sided Chest Study of Skin Rejuvenation Comparing Low‐Energy, 1,927‐nm Thulium Fractional Laser Treatment Prior to Photodynamic Therapy Versus Photodynamic Therapy Alone

Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life

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