Nonablative Remodeling: Clinical, Histologic, Ultrasound Imaging, and Profilometric Evaluation of a 1540 nm Er:Glass Laser

Abstract

This study has clearly demonstrated that irradiation with 1540 nm Er:glass laser can lead to new collagen formation, dermis thickening, reduction of anisotropy of the skin, and clinical improvements. The lack of adverse effects confirmed that this 1540 nm laser emitting in a pulsed mode coupled with an efficient cooling system is safe.

Skin responses to fractional photothermolysis

“…Some authors report evidence of new collagen formation as detected by the evaluation of regular H&E stain or orcein stain after non-ablative resurfacing [11][12][13][14]. After consultation with several independent dermatopathologists, we are hesitant to draw this conclusion from the evaluation of the collagen alignment in the H&E stained tissue sections alone.…”

Treatment of Atrophic Facial Acne Scars With the 1064-nm Q-Switched Nd:YAG Laser

“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Histologic studies have confirmed production and deposition of new collagen after thermal damage induced by nonablative laser treatments. 10,14,18 Although previous studies have shown that nonablative laser treatments result in qualitative improvements in facial rhytids and scars, there has been an inherent difficulty in quantifying the effects of nonablative resurfacing. [9][10][11][14][15][16]23 Clinical and photographic assessments are subjective and often operator dependent.…”

Clinical Efficacy of Devices for Nonablative Photorejuvenation

“…[6][7][8][9][10][11][12][13][14][15][16] Treatment regimens ranged from a single procedure 6 to 8 treatments at 2-to 3-week intervals. 11 In 10 of the trials, the clinical end point consisted of observation only.…”