Nonadditivity in interactions between three membrane-wrapped colloidal spheres

Azadbakht, Ali; Meadowcroft, Billie; Májek, Juraj; Šarić, Anđela; Kraft, Daniela J.

doi:10.1016/j.bpj.2023.12.020

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…In this case, the NPs are dispersed on the membrane and are fairly diffusive . In contrast, the NPs are either highly wrapped or endoyctosed by membranes at low tension and high adhesive interactions. , At intermediate adhesive interactions, however, the deformations caused by the adhesion of the NPs to the membrane extend over length scales well beyond the size of the NPs and give rise to an effective membrane-curvature-mediated interaction between them. ,, Experiments and simulations have shown that this interaction can result in NPs’ aggregation into in-plane or out-of-plane linear chains. ,,,,,,− Two generic aspects of these assemblies are that they are linear, and neighboring NPs within the assemblies are practically in contact with each other.…”

Section: Introductionmentioning

confidence: 99%

Highly Ordered Nanoassemblies of Janus Spherocylindrical Nanoparticles Adhering to Lipid Vesicles

Sharma,

Zhu,

Spangler

et al. 2024

ACS Nano

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In recent years, there has been a heightened interest in the self-assembly of nanoparticles (NPs) that is mediated by their adsorption onto lipid membranes. The interplay between the adhesive energy of NPs on a lipid membrane and the membrane’s curvature energy causes it to wrap around the NPs. This results in an interesting membrane curvature-mediated interaction, which can lead to the self-assembly of NPs on lipid membranes. Recent studies have demonstrated that Janus spherical NPs, which adhere to lipid vesicles, can self-assemble into well-ordered nanoclusters with various geometries, including a few Platonic solids. The present study explores the additional effect of geometric anisotropy on the self-assembly of Janus NPs on lipid vesicles. Specifically, the current study utilized extensive molecular dynamics simulations to investigate the arrangement of Janus spherocylindrical NPs on lipid vesicles. We found that the additional geometric anisotropy significantly expands the range of NPs’ self-assemblies on lipid vesicles. The specific geometries of the resulting nanoclusters depend on several factors, including the number of Janus spherocylindrical NPs adhering to the vesicle and their aspect ratio. The lipid membrane-mediated self-assembly of NPs, demonstrated by this work, provides an alternative cost-effective route for fabricating highly engineered nanoclusters in three dimensions. Such structures, with the current wide range of material choices, have great potential for advanced applications, including biosensing, bioimaging, drug delivery, nanomechanics, and nanophotonics.

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Section: Introductionmentioning

confidence: 99%

Highly Ordered Nanoassemblies of Janus Spherocylindrical Nanoparticles Adhering to Lipid Vesicles

Sharma,

Zhu,

Spangler

et al. 2024

ACS Nano

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Nonadditivity in Many-Body Interactions between Membrane-Deforming Spheres Increases Disorder

Azadbakht,

Weikl,

Kraft

2024

ACS Nano

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Membrane-induced interactions play an important role in organizing membrane proteins. Measurements of the interactions between two and three membrane deforming objects have revealed their nonadditive nature. They are thought to lead to complex many-body effects, however, experimental evidence is lacking. We here present an experimental method to measure many-body effects in membrane-mediated interactions using colloidal spheres placed between a deflated giant unilamellar vesicles and a planar substrate. The confined colloidal particles cause a large deformation of the membrane while not being physicochemically attached to it and interact through it. Two particles attract with a maximum force of 0.2 pN. For three particles, compact equilateral triangles were preferred over linear arrangements. We use numerical energy minimization to establish that the attraction stems from a reduction in the membrane-deformation energy caused by the particles. Confining up to 36 particles, we find a preference for hexagonally close packed clusters. However, with increasing number of particles the order of the confined particles decreases, at the same time, diffusivity of the particles increases. Our experiments show that the nonadditive nature of membrane-mediated interactions affects the interactions and arrangements and ultimately leads to spherical aggregates with liquid-like order of potential importance for cellular processes.

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Nonadditivity in interactions between three membrane-wrapped colloidal spheres

Cited by 2 publications

References 43 publications

Highly Ordered Nanoassemblies of Janus Spherocylindrical Nanoparticles Adhering to Lipid Vesicles

Highly Ordered Nanoassemblies of Janus Spherocylindrical Nanoparticles Adhering to Lipid Vesicles

Nonadditivity in Many-Body Interactions between Membrane-Deforming Spheres Increases Disorder

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