Nonalcoholic fatty liver disease

Sotiropoulou, Maria; Katsaros, Ioannis; Vailas, Michail; Lidoriki, Irene; Papatheodoridis, George; Kostomitsopoulos, Nikolaos; Valsami, Georgia; Tsaroucha, Alexandra; Schizas, Dimitrios

doi:10.4103/sjg.sjg_249_21

Cited by 19 publications

(5 citation statements)

References 107 publications

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“…These above results were consistent with the results reported in the literature that rutin and quercetin exhibited hepatoprotective effects [29][30][31][32][33][34][35][36][37]. Liu et al [29] tried to investigate the molecular mechanisms underlying rutin's hypolipidemic and hepatoprotective effects in NAFLD.…”

Section: Histopathological Studiessupporting

confidence: 88%

“…The data showed that quercetin appears to be a promising hepatoprotective compound. Sotiropoulou et al [33] clearly demonstrated that quercetin had potent antioxidative stress action and inhibitory effects on hepatocyte apoptosis, inflammation, and generation of reactive oxygen species, factors which were linked to the development of the disease. Ying et al [34] also showed that oral administration of quercetin at doses of 30-60 mg/kg to hyperlipidemic rats for 14 days was highly effective in decreasing the levels of serum TC, TG, LDL-C, ALT and AST.…”

Section: Histopathological Studiesmentioning

confidence: 99%

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Mechanochemical-Assisted Extraction and Hepatoprotective Activity Research of Flavonoids from Sea Buckthorn (Hippophaë rhamnoides L.) Pomaces

Guo¹,

Cheng²,

Zheng³

et al. 2021

Molecules

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Pomaces of sea buckthorn berry were usually side-products during the processing of juice. Due to a lack of an economical and effective extraction method, it was typically recognized as waste. For the purpose of resource utilization, the mechanochemical-assisted extraction (MCAE) method was applied to develop an ecofriendly extraction method and product with better pharmacology activity. The parameters were investigated through response surface methodology (RSM) design experiments. The processing conditions were optimized as follows: amount of Na2CO3 40%, ball-to-material rate 29:1 g/g, milling speed 410 rpm, milling time 24 min, extraction temperature 25 °C, extraction time 20 min and the solid-to-solution ratio 1:10 g/mL. Under these conditions, the yields of flavonoids from sea buckthorn pomaces were 26.82 ± 0.53 mg/g, which corresponds to an increase of 2 times in comparison with that extracted by the heat reflux extraction method. Meanwhile, the hepatoprotective activity of sea buckthorn pomaces extracts was studied by the liver injury induced by ip injection of tetracycline. Biochemical and histopathological studies showed that biomarkers in serum and liver of nonalcoholic fatty liver disease (NAFLD) mice were significantly ameliorated when sea buckthorn flavonoids extracted by MCAE were used. Altogether, these results demonstrate that, as a green and efficient extraction, MCAE treatment could increase the extraction yield of sea buckthorn flavonoids, meanwhile it could exhibit significant activity of improving liver function. This research provided a new way to use pomaces of sea buckthorn as a functional food. It also has great value on the comprehensive utilization of nature’s resources.

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Section: Histopathological Studiessupporting

confidence: 88%

Section: Histopathological Studiesmentioning

confidence: 99%

Mechanochemical-Assisted Extraction and Hepatoprotective Activity Research of Flavonoids from Sea Buckthorn (Hippophaë rhamnoides L.) Pomaces

Guo¹,

Cheng²,

Zheng³

et al. 2021

Molecules

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“…Except that capsaicin and cucurbitacin B have high toxicity in mice, the other compounds do not produce obvious toxicity or adverse effects in acute/chronic animal toxicity test or cytotoxicity test, representing their potentials as safe and effective therapeutics drugs or nutritional supplements for the treatment of liver diseases. In fact, some of these compounds, including betaine, caffeine, chlorogenic acid, curcumin, EGCG, genistein, hesperidin, lipoic acid, naringenin, quercetin, resveratrol, sulforaphane, vitamin C and vitamin E, have been reported to be effective and safe in preventing or alleviating the symptoms of liver diseases patient in randomized controlled trials [9,[11][12][13][14]30,45,86,103,145,157,200,226,316].…”

Section: Discussionmentioning

confidence: 99%

“…Quercetin is a natural flavonoid compound (Fig. 3f) and is readily available from various fruits and vegetables, such as berries, apples, onions, broccoli, pepper and tomato [200]. In the CCl 4 -induced rat liver fibrosis model, quercetin normalizes the liver function and fibrosis markers through balancing profibrogenic/antifibrogenic factors, promoting HSCs apoptosis, or inhibiting Bcl-2/Bax-mediated hepatocytes apoptosis, oxidative state, and NFкB/IкBα-p38 MAPK-mediated inflammation [201,202].…”

Section: Natural Compounds Derived From Edible Plantsmentioning

confidence: 99%

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

Wang

Niu

et al. 2022

European Journal of Gastroenterology &Amp; Hepatology

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Liver fibrosis has a high incidence worldwide and is the common pathological basis of many chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular matrix and concomitant collagen accumulation in livers and can lead to the development of liver cirrhosis and even liver cancer. A large number of studies have provided evidence that liver fibrosis can be blocked or even reversed by appropriate medical interventions. However, the antifibrosis drugs with ideal clinical efficacy are still insufficient. The edible plant-derived natural compounds have been reported to exert effective antifibrotic effects with few side-effects, representing a kind of promising source for the treatment of liver fibrosis. In this article, we reviewed the current progress of the natural compounds derived from dietary plants in the treatment of liver fibrosis, including phenolic compounds (capsaicin, chlorogenic acid, curcumin, ellagic acid, epigallocatechin-3-gallate, resveratrol, sinapic acid, syringic acid, vanillic acid and vitamin E), flavonoid compounds (genistein, hesperidin, hesperetin, naringenin, naringin and quercetin), sulfur-containing compounds (S-allylcysteine, ergothioneine, lipoic acid and sulforaphane) and other compounds (betaine, caffeine, cucurbitacin B, lycopene, α-mangostin, γ-mangostin, ursolic acid, vitamin C and yangonin). The pharmacological effects and related mechanisms of these compounds in in-vivo and in-vitro models of liver fibrosis are focused.

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“…It possesses several pharmacological properties, including antioxidant activity against free radicals, antibacterial properties, and cancer-fighting properties. Acacia rice is a rich source of quercetin and contains a high amount of this compound [39]. Quercetin is a flavonoid with potent oxidative properties and many studies have shown that it can significantly reduce lipid accumulation and SREBP1c and XBP-1 expression in adipocytes.…”

Section: Quercetinmentioning

confidence: 99%

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

et al. 2023

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and its incidence continues to increase each year. Yet, there is still no definitive drug that can stop its development. This review focuses mainly on lipotoxicity, oxidative stress, inflammation, and intestinal flora dysbiosis to understand NAFLD’s pathogenesis. In this review, we used NCBI’s PubMed database for retrieval, integrating in vivo and in vitro experiments to reveal the therapeutic effects of natural compounds on NAFLD. We also reviewed the mechanisms by which the results of these experiments suggest that these compounds can protect the liver from damage by modulating inflammation, reducing oxidative stress, decreasing insulin resistance and lipid accumulation in the liver, and interacting with the intestinal microflora. The natural compounds discussed in these papers target a variety of pathways, such as the AMPK pathway and the TGF-β pathway, and have significant therapeutic effects. This review aims to provide new possible therapeutic lead compounds and references for the development of novel medications and the clinical treatment of NAFLD. It offers fresh perspectives on the development of natural compounds in preventing and treating NAFLD.

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Nonalcoholic fatty liver disease

Cited by 19 publications

References 107 publications

Mechanochemical-Assisted Extraction and Hepatoprotective Activity Research of Flavonoids from Sea Buckthorn (Hippophaë rhamnoides L.) Pomaces

Mechanochemical-Assisted Extraction and Hepatoprotective Activity Research of Flavonoids from Sea Buckthorn (Hippophaë rhamnoides L.) Pomaces

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

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