Nonalcoholic Fatty Liver Disease, Male Sexual Dysfunction, and Infertility: Common Links, Common Problems

Hawksworth, Dorota J.; Burnett, Arthur L.

doi:10.1016/j.sxmr.2019.01.002

Cited by 34 publications

(17 citation statements)

References 111 publications

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“…These mechanisms are supported by the clinical findings in a study of NAFLD patients that found significantly reduced flow-mediated vasodilation compared with age-and sex-matched control subjects [158]. As endothelial dysfunction is the main mechanism of erectile dysfunction in men, erectile dysfunction was shown to be a relevant issue in patients with NAFLD [159].…”

Section: Endothelial Dysfunctionmentioning

confidence: 71%

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

Niederseer

Wernly

Aigner

et al. 2021

JCM

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Overwhelming evidence suggests an association of cardiovascular disease (CVD) with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain largely speculative. It is, however, likely that common mechanisms contribute to the development of CVD and NAFLD, with lifestyle factors such as smoking, sedentary lifestyle with poor nutrition habits and physical inactivity being major candidates. These behavioral factors, on a predisposing genetic background, trigger changes in gut microbiota, inflammation, dyslipidemia and oxidative stress, leading to metabolic syndrome, diabetes and obesity as well as atherosclerosis. Treatment options to counteract both the progression and development of CVD and NAFLD include lifestyle interventions, optimal medical therapy of comorbid conditions and, as final possibility, bariatric surgery. As no causal pharmacotherapy of NAFLD is available, further research is urgently needed to address the unmet need of a growing population with NAFLD and CVD.

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Section: Endothelial Dysfunctionmentioning

confidence: 71%

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

Niederseer

Wernly

Aigner

et al. 2021

JCM

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“…Erectile dysfunction (ED), defined as the inability to attain and/or maintain an erection satisfactorily during sexual acts, affects about 50% of men in the United States and approximately 322 million men worldwide [196]. The pathological alterations underlying ED have many of the same risk factors as MetS, including hypertension, dyslipidemia, physical inactivity, and visceral obesity [197].…”

Section: Resultsmentioning

confidence: 99%

“…EndocrinopathiesPolycystic ovarian syndromeHypothyroidismObesity and IR are common risk factors for both PCOS and NAFLD [207,208,209,210]. The prevalence of NAFLD is higher in patients with hypothyroidism; furthermore, low thyroid function seems to worsen the progression of liver damage, while replacement therapy may improve liver function [187,188,189,194,195,196,197]. Emerging LinkagesOsteoporosisNAFLD is associated with a 2.5-fold risk of osteoporotic fractures [122,124,125].…”

Section: Table A1mentioning

confidence: 99%

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Rosato

Masarone

Dallio

et al. 2019

IJERPH

104

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis, male sexual dysfunction, periodontitis, and urolithiasis. The most common cause of mortality in NAFLD is represented by cardiovascular disease, followed by liver-related complications. Therefore, clinicians should learn to screen and initiate treatment for these extra-hepatic manifestations, in order to provide appropriate multidisciplinary assessments and rigorous surveillance. This review evaluates the current evidence regarding extra-hepatic associations of NAFLD, focusing on the pathogenic hypothesis and the clinical implications.

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“…Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease characterized by the accumulation of fat in the liver, which can be associated with obesity, and can progress to brosis, cirrhosis, and even liver cancer [1].NAFLD is considered as an important feature of metabolic syndrome and an important factor causing cardiovascular diseases. More studies have suggested that NAFLD is related to male sexual dysfunction and reproductive dysfunction [2].NAFLD has also been shown to be associated with poor metabolism and oxidative stress [3].Other studies have linked NAFLD to sedentary behavior and poor eating habits [4].NAFLD is one of the most common chronic liver diseases in developed countries [5]. Except for lifestyle intervention, no drugs are currently approved for the treatment of NAFLD, so more clinical studies are needed to nd new methods for the treatment and management of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Study on the Independent Effect of Thyroid Hormone Based on Uric Acid Level on NAFLD

Chao

Chen

2020

Preprint

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Objective:This study aims to further explain the correlation among NAFLD, hyperuricemia and thyroid function and to find independent risk factors for each other.Methods:Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2017 to February 2019.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Serum uric acid (SUA) >360 mol/L (female) and SUA>420 mol/L (male) were enrolled in the hyperuricemia group.R software was used for statistical analysis.Results:55,449 subjects were included in the analysis.Gender ratio, age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, triglyceride, high-density lipoprotein, glutamate transaminase, glutamate transaminase, urea nitrogen, creatinine, FT3, FT4 and TSH were significantly different between the two groups.age, BMI, waist circumference, diastolic blood pressure, rapid blood glucose, HbA1c, total cholesterol, low-density lipoprotein, AST, and uric acid were all independent risk factors for NAFLD.In the normal uric acid group, variables other than systolic blood pressure and TSH were independent factors of NAFLD.In the hyperuricemia group, all variables except systolic blood pressure, FT4 and TSH were independent factors of NAFLD.Conclusion:The level of uric acid is related to the occurrence of NAFLD. Hyperuricemia is one of the independent risk factors of NAFLD.TSH level is not related to the occurrence of NAFLD, while FT3 and FT4 may be related to NAFLD.

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Nonalcoholic Fatty Liver Disease, Male Sexual Dysfunction, and Infertility: Common Links, Common Problems

Cited by 34 publications

References 111 publications

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Study on the Independent Effect of Thyroid Hormone Based on Uric Acid Level on NAFLD

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