Nonalcoholic Fatty Liver Disease: US-based Acoustic Radiation Force Impulse Elastography

Yoneda, Masato; Suzuki, Kaori; Kato, Shingo; Fujita, Koji; Nozaki, Yuichi; Hosono, Kunihiro; Saito, Satoru; Nakajima, Atsushi

doi:10.1148/radiol.10091662

Cited by 330 publications

(248 citation statements)

References 26 publications

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“…|G * | reflects the stiffness or softness of the tissue and is closely related to the shear wave speed measured by transient stimulation methods in ultrasound elastography. Our group mean value of |G * | = 1.27 ± 0.17 kPa for the liver falls in the range of shear modulus values (1.1 to 1.8 kPa) measured by Fibroscan [36,37] or ARFI [37,38] ultrasound devices. The phase angle of the complex modulus φ = arctan[Im(G * )/Re(G * )] is a relatively unexplored parameter within the field of elastography.…”

supporting

confidence: 58%

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo

Hirsch

Streitberger

et al. 2013

Fortschr Röntgenstr

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Purpose: To introduce a novel in-vivo three-dimensional multifrequency magnetic resonance elastography (3D-MMRE) method for high-resolution mechanical characterization of the liver and spleen. Materials and Methods: Ten healthy volunteers were examined by abdominal single-shot 3D-MMRE using a novel patient-activated trigger system with respiratory control. 10 contiguous slices with 2.5?mm cubic voxel resolution, 3 wave components, 8 time steps, and 2 averages were acquired at 7 mechanical excitation frequencies from 30 to 60?Hz. The total imaging time was approximately 15?min. For postprocessing, multifrequency dual elasto-visco (MDEV) inversion was used to calculate high-resolution mechanical parameter maps of the abdomen including the liver and spleen. Results: Two parameters maps were generated from each image slice to capture the magnitude and the phase angle of the complex shear modulus. Both parameters depicted the mechanical structures of the abdomen with unprecedented high spatial resolution. Spatially averaged group mean values of the liver and spleen are 1.27???0.17 kPa and 2.01???0.69 kPa, indicating a significantly higher asymptomatic stiffness of the spleen compared to the liver. Conclusion: Patient-activated respiratory-gated 3D-MMRE combined with MDEV inversion provides highly resolved mechanical maps of the liver and spleen that are superior to previous elastograms measured by abdominal MRE. Citation Format: ??Guo J, Hirsch S, Streitberger KJ et?al. Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen. Fortschr R?ntgenstr 2014; 186: 260???266

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supporting

confidence: 58%

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo

Hirsch

Streitberger

et al. 2013

Fortschr Röntgenstr

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“…Conventional ultrasound (US) was performed using the ACUSON S2000 US System (Mochida Siemens Medical System, Tokyo, Japan) equipped with a large-format 50-mm linear array transducer with a bandwidth of 6-18 MHz (Yoneda et al 2010;Tozaki et al 2011). ARFI imaging (Virtual Touch Tissue Quantification, Mochida Siemens) was performed using the linear array transducer (9L4, Mochida Siemens) with a bandwidth of 4-9 MHz (Yoneda et al 2010;Tozaki et al 2011).…”

Section: Measurement Of Shear Wave Velocity With Vttqmentioning

confidence: 99%

“…ARFI imaging (Virtual Touch Tissue Quantification, Mochida Siemens) was performed using the linear array transducer (9L4, Mochida Siemens) with a bandwidth of 4-9 MHz (Yoneda et al 2010;Tozaki et al 2011). An acoustic push pulse and detection pulse were used to calculate the shear wave velocity (measured in m/second), which increases with the tissue stiffness (Yoneda et al 2010;Tozaki et al 2011). VTTQ involves targeting the lesions to be examined for its elastic properties with a region-of-interest (ROI) cursor having a fixed dimension of 5 × 5 mm (Yoneda et al 2010;Tozaki et al 2011).…”

Section: Measurement Of Shear Wave Velocity With Vttqmentioning

confidence: 99%

“…An acoustic push pulse and detection pulse were used to calculate the shear wave velocity (measured in m/second), which increases with the tissue stiffness (Yoneda et al 2010;Tozaki et al 2011). VTTQ involves targeting the lesions to be examined for its elastic properties with a region-of-interest (ROI) cursor having a fixed dimension of 5 × 5 mm (Yoneda et al 2010;Tozaki et al 2011). In all patients, these US examinations were performed by one breast surgeon (K.T., 10 years of experience in breast US) at Nahanishi Clinic Okinawa.…”

Section: Measurement Of Shear Wave Velocity With Vttqmentioning

confidence: 99%

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Non-Invasive Evaluation of Axillary Lymph Node Status in Breast Cancer Patients Using Shear Wave Elastography

Tamaki¹,

Tamaki²,

Kamada³

et al. 2013

Tohoku J. Exp. Med.

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Less invasive procedures are currently required to examine the axillary lymph node status. Shear wave elastography with acoustic radiation force impulse provides objective and reproducible quantification of the intrinsic property of the soft tissue. In this study, we measured shear wave velocity of the axillary lymph nodes of patients with breast cancer using Virtual Touch Tissue Quantification (VTTQ). The degree of lymph node metastasis was evaluated by measuring the expression level of cytokeratin 19 (CK19) mRNA, a specific marker for breast cancer cells. The one-step nucleic acid amplification (OSNA) was used to determine the copy number of CK19 mRNA in 149 lymph node specimens of 149 primary breast cancer patients. Axillary lymph node status according to OSNA (copy number/μl) were categorized as 0-249 copies (−), 250-5,000 copies (+), and copy number > 5,000 (++). A category (−) represents no metastasis in the axillary lymph node. There were 121 patients with OSNA−, 9 with OSNA+ and 19 with OSNA++. The average velocities according to OSNA categories were 1.64 ± 0.42 m/second for OSNA−, 2.25 ± 0.78 m/second for OSNA+, and 2.79 ± 0.98 m/second for OSNA++. There were significant differences in the shear wave velocity between OSNA− and OSNA+ (P = 0.040) or OSNA++ (P < 0.001). The most optimal cutoff velocity to distinguish benign from metastasis is 1.44 m/second, as determined using the receiver operating characteristic method. The shear wave velocity measured with VTTQ could provide clinically useful information about axillary lymph node metastasis in patients with primary breast cancer.

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“…This was shown to be extremely difficult in external ultrasound elastography, where images obtained during application of strong pressure can lead to misdiagnosis (11). Recently, investigators have used acoustic radiation force impulse (ARFI) imaging to overcome this fault (21). ARFI imaging uses radiation impulses to induce localized displacement of tissues, then monitors the dynamic response of tissues to the induced displacement (22).…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Elastography: the next step

Das¹,

Gupta²,

Kaur³

et al. 2011

J Oral Sci

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Abstract:In the past few decades, various tools have emerged that claim to enhance detection of oral cancer. The most important prognostic factor in patients with oral cancer is lymph node status: the presence of nodal spread decreases the 5-year survival rate by approximately 50%. Differentiation between reactive and metastatic lymphadenopathy is thus vital, and one differentiating criterion is hardness (elasticity) of the lymph node. The purpose of this review is to highlight a promising new ultrasound technique, known as elastography, which measures the characteristics of tissue compliance. The principles underlying elastography are that tissue compression produces strain (displacement) within the tissue -which is lower in harder tissues than in softer tissues -and that malignant tissues are generally harder than normal surrounding tissue. Therefore, elastography might yield clinical information useful in diagnosing cervical metastasis and improving prognosis in oral cancer. It has long been used for cancers of the breast, pancreas, and thyroid, and its use in cervical lymphadenopathy is now being explored, which could lead to great advancements in the diagnosis and prognosis of oral cancer. (J Oral Sci 53, 137-141, 2011)

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Nonalcoholic Fatty Liver Disease: US-based Acoustic Radiation Force Impulse Elastography

Abstract: There is a significant positive correlation between median velocity measured by using ARFI sonoelastography and severity of liver fibrosis in patients with NAFLD. The results of ARFI sonoelastography were similar to those of transient sonoelastography.

Cited by 330 publications

References 26 publications

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Non-Invasive Evaluation of Axillary Lymph Node Status in Breast Cancer Patients Using Shear Wave Elastography

Elastography: the next step

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