Nonalcoholic fatty pancreas disease

Mathur, Abhishek; Marine, Megan B.; Lu, Da-Yong; Swartz-Basile, Deborah A.; Saxena, Romil; Zyromski, Nicholas J.; Pitt, Henry A.

doi:10.1080/13651820701504157

Cited by 174 publications

(146 citation statements)

References 44 publications

(63 reference statements)

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“…In this model, circulating adiponectin inversely mirrored the severity of AP. We have also observed that pancreata of obese mice contain an increased volume of fat, a different composition of fat, and increased basal level of proinflammatory cytokines interleukin-1b (IL-1b), and interleukin-6 (IL-6) relative to wild-type lean mice [5,6].…”

Section: Introductionmentioning

confidence: 88%

“…Obesity is associated with fatty infiltration in the heart, kidney, liver, and pancreas. This situation leads to a generalized proinflammatory milieu and subsequent organ dysfunction [3][4][5][6]. Acute pancreatitis (AP) represents a substantial clinical problem, accounting for over 240,000 hospital admission annually in the United States, at a cost of over $2.3 billion [7].…”

Section: Introductionmentioning

confidence: 99%

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Acute Pancreatitis in Obesity: Adipokines and Dietary Fish Oil

et al. 2011

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Acute Pancreatitis in Obesity: Adipokines and Dietary Fish Oil

et al. 2011

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“…Fatty pancreas is associated with decreased β -cell function and impaired insulin secretion in small case series ( 12,13 ). Pro-infl ammatory cytokines such as tumor necrosis factor-alpha and interleukin-1 β are increased in the pancreas of obese mice ( 14 ). Such animals also have an abnormal pancreatic islet size ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Fatty Pancreas, Insulin Resistance, and β-Cell Function: A Population Study Using Fat-Water Magnetic Resonance Imaging

Wong

Yeung

et al. 2014

American Journal of Gastroenterology

221

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OBJECTIVES:Nonalcoholic fatty liver disease is the most common chronic liver disease. Fatty pancreas has also been described but is diffi cult to assess. It is now possible to measure pancreatic and liver fat accurately with magnetic resonance imaging (MRI). We aimed to defi ne the normal range of pancreatic fat and identify factors associated with fatty pancreas. In addition, the effect of fatty liver and fatty pancreas on insulin resistance (IR) and pancreatic ␤ -cell function was studied. METHODS:Fat-water MRI and proton-magnetic resonance spectroscopy were performed on 685 healthy volunteers from the general population to measure pancreatic and liver fat, respectively. On the basis of fasting plasma glucose and insulin levels, the IR and ␤ -cell function were assessed using the homeostasis model assessment (HOMA). RESULTS:Among subjects without signifi cant alcohol consumption or any component of metabolic syndrome, 90 % had pancreatic fat between 1.8 and 10.4 % . Using the upper limit of normal of 10.4 % , 110 (16.1 % ; 95 % confi dence interval 13.3 -18.8 % ) subjects had fatty pancreas. On multivariable analysis, high serum ferritin, central obesity, and hypertriglyceridemia were independent factors associated with fatty pancreas. Subjects with both fatty pancreas and fatty liver had higher HOMA-IR than did those with either condition alone. Fatty pancreas was not associated with HOMA-β after adjusting for liver fat and body mass index.CONCLUSIONS: In all, 16.1 % of this community cohort of adult Hong Kong Chinese volunteers had a fatty pancreas by our defi nition. Central obesity, hypertriglyceridemia, and hyperferritinemia are associated with fatty pancreas. Individuals with fatty pancreas have increased IR.

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“…In addition, some experimental work has begun to address the mechanisms by which fat contributes to pancreatic disease. Recent data from our laboratory showed that obese Lep ob mice have an elevated pancreatic fat content and increased baseline levels of the proinflammatory cytokines TNF-␣ and IL-1 ␤ relative to lean wild-type mice [3] . In addition, obese leptin-deficient Lep ob and obese hyperleptinemic Lep db mice develop more severe pancreatitis than lean mice when subjected to cerulein hyperstimulation [16] .…”

Section: Introductionmentioning

confidence: 99%

Nuclear Magnetic Resonance Spectroscopy-Based Metabolomics of the Fatty Pancreas: Implicating Fat in Pancreatic Pathology

et al. 2009

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Background: Obesity is a worldwide epidemic and a significant risk factor for pancreatic diseases including pancreatitis and pancreatic cancer; the mechanisms underlying this association are unknown. Metabolomics is a powerful new analytical approach for describing the metabolome (compliment of small molecules) of cells, tissue or biofluids at any given time. Our aim was to analyze pancreatic fat content in lean and congenitally obese mice using both metabolomic analysis and conventional chromatography. Methods: The pancreatic fat content of 12 lean (C57BL/6J), 12 obese leptin-deficient (Lep^ob) and 12 obese hyperleptinemic (Lep^db) mice was evaluated by metabolomic analysis, thin-layer and gas chromatography. Results: Pancreata of congenitally obese mice had significantly more total pancreatic fat, triglycerides and free fatty acids, but significantly less phospholipids and cholesterol than those of lean mice. Metabolomic analysis showed excellent correlation with thin-layer and gas chromatography in measuring total fat, triglycerides and phospholipids. Conclusions: Differences in pancreatic fat content and character may have important implications when considering the local pancreatic proinflammatory milieu in obesity. Metabolomic analysis is a valid, powerful tool with which to further define the mechanisms by which fat impacts pancreatic disease.

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Nonalcoholic fatty pancreas disease

Abstract: These data suggest that obese mice have 1) heavier pancreata, 2) more pancreatic fat, especially triglycerides and FFAs, and 3) increased cytokines. We conclude that obesity leads to nonalcoholic fatty pancreatic disease.

Cited by 174 publications

References 44 publications

Acute Pancreatitis in Obesity: Adipokines and Dietary Fish Oil

Acute Pancreatitis in Obesity: Adipokines and Dietary Fish Oil

Fatty Pancreas, Insulin Resistance, and β-Cell Function: A Population Study Using Fat-Water Magnetic Resonance Imaging

Nuclear Magnetic Resonance Spectroscopy-Based Metabolomics of the Fatty Pancreas: Implicating Fat in Pancreatic Pathology

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