Nonalcoholic Wernicke’s Encephalopathy with Prominent Astasia and Optic Neuropathy

Gökçe, Mustafa; Bülbüloğlu, Ertan; Tuncel, Defne Ay; Özdemir, Gökhan; It, Kale

doi:10.1159/000088119

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Most cases of optic disc swelling caused by thiamine deficiency (90%; 36/40) [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] were young women (mean age = 28 years, range = 11–56 years), matching the typical demographic of IIH patients ( Table 2 and Tables S5 and S6 ). The cause of thiamine deficiency was predominately due to reduced intake (62.5%; 25/40) due to anorexia, nausea, vomiting or restrictive diets.…”

Section: Resultsmentioning

confidence: 99%

Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review

et al. 2022

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Idiopathic intracranial hypertension (IIH) is a neurological disorder characterised by optic disc swelling secondary to raised intracranial pressure (ICP) of unknown cause. Obesity is the most established and prevalent risk factor in developed countries. As obesogenic diets are high in calories and nutrient-poor, there may be associated nutritional deficiencies that contribute to the clinical presentation of IIH. Yet none, aside from iron deficiency, are currently included in the inclusion or exclusion criteria for the diagnosis of IIH. Our primary aim was to determine which micronutrient deficiencies, aside from iron deficiency, could present with optic disc swelling associated with or without intracranial hypertension that could potentially meet current IIH diagnostic criteria. To this end, we conducted a systematic search of articles published between 1 January 1980 and 18 December 2020 reporting cases of optic disc swelling associated with micronutrient deficiencies. In total, 65 cases met the eligibility criteria from initial searches: all were case reports and case series with a high risk of bias. Our findings suggest that patients with IIH or unexplained optic disc swelling ought to be screened, investigated, and treated for associated micronutrient deficiencies in vitamin A, B1 and B12; and weight loss interventions in IIH patients ought to promote better nutrition in addition to overall calorie restriction.

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Section: Resultsmentioning

confidence: 99%

Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review

et al. 2022

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“…These symptoms may develop acutely or chronically. Although the disease is most commonly seen on the basis of chronic alcoholism, it may also be seen in hyperemesis gravidarum, systemic malignity, gastrointestinal surgery, hemodialysis or peritoneal dialysis, longstanding intravenous nutrition, anorexia nervosa, dieting or hunger strike, and acquired immunodeficiency (1,2). Whether it is the result of inadequate intake, malabsorption or increased metabolic need, the main cause is thiamine deficiency due to nutritional status.…”

Section: Dear Editormentioning

confidence: 99%

Körle Yatan Şaşı Kalkar: Wernicke Ensefalopatisi

Uca

2014

npa

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“…WE'nin klinisyenler, beslenme uzmanları ve radyoloji uzmanları tarafından yeterince bilinmemesi, ayrıca sağlık politikalarının dolaylı etkisi sonucu hastanelerin ilaç teminindeki sıkıntılar gibi etkenler nedeniyle tüm dünyada olduğu gibi, ülkemizde de bu hastalığın tahmin edilenden daha sık görülüyor olması ve görülmeye devam edeceği kuvvetle muhtemeldir (14,15). Farkındalığın arttırılması ile daha çok sayıda vaka erken tanı alabilir ve tedavi edilebilir.…”

Section: Sonuçunclassified

Three Iatrogenic Cases of Wernicke’s Encephalopathy From Turkey: An Early Warning

Vural¹,

Temuçin²,

Arsava³

et al. 2011

Yoğun Bakim Derg

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Wernicke's encephalopathy (WE) is classically known as a disease which presents with encephalopathy, ataxia and ophtalmoparesis and is commonly observed in alcoholics due to nutritional deficiency. Recently, an increasing number of case reports and research articles in the literature has shown that this disease may be seen in nonalcoholics much more frequently than previously acknowledged. Apart from patients with cancer, hyperemesis gravidarum and bariatric surgical interventions, long-term hospitalised patients receiving total parenteral nutrition (TPN) without multivitamin supplementation are at risk for iatrogenic WE. Iatrogenic cases have been reported in many countries, especially during periods when changes in national health insurance policies take place. In this report, we present three patients who were diagnosed with iatrogenic WE after long-term hospitalisation and discuss predisposing factors as well as diagnostic and therapeutic issues related to this entity. (Yoğun Bakım Derg 2011; 3: 71-5)

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Nonalcoholic Wernicke’s Encephalopathy with Prominent Astasia and Optic Neuropathy

Cited by 7 publications

References 18 publications

Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review

Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review

Körle Yatan Şaşı Kalkar: Wernicke Ensefalopatisi

Three Iatrogenic Cases of Wernicke’s Encephalopathy From Turkey: An Early Warning

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